Macelignan attenuated allergic lung inflammation and airway hyper-responsiveness in murine experimental asthma
Macelignan isolated from Myristica fragrans Houtt. is widely used for spice and flavoring for foods, and has been reported to have anti-inflammatory activity. The aim of this study was to investigate the effects of macelignan on allergic lung inflammation with a murine model of experimental asthma....
Gespeichert in:
| Veröffentlicht in: | Life sciences (1973) 2013-06, Vol.92 (22), p.1093-1099 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1099 |
|---|---|
| container_issue | 22 |
| container_start_page | 1093 |
| container_title | Life sciences (1973) |
| container_volume | 92 |
| creator | Shin, Kihyuk Chung, Hee-chul Kim, Do-Un Hwang, Jae-Kwan Lee, Seung-Hyo |
| description | Macelignan isolated from Myristica fragrans Houtt. is widely used for spice and flavoring for foods, and has been reported to have anti-inflammatory activity. The aim of this study was to investigate the effects of macelignan on allergic lung inflammation with a murine model of experimental asthma.
Fungal protease mixed with chicken egg ovalbumin allergen was used as a challenge to induce murine experimental asthma. To determine its effects on allergy and inflammation, macelignan was administered orally during allergen challenge, and the symptoms of allergic asthma and its underlined mechanisms were examined.
Treatment with macelignan attenuated eosinophilic airway inflammation and airway hyper-responsiveness. With the administration of macelignan, interleukin-4 (IL-4) producing cells, but not interferon-γ (IFN-γ) or IL-17 producing cells, were diminished in the lungs. Additionally, activation of the T helper type 2 (Th2) cell-specific master transcription factor, GATA3 was decreased with macelignan treatment. Finally, production of IL-4 but not IFN-γ or IL-17, by CD4+ T cells was reduced with stimulation when combined with the administration of macelignan.
Our data show that macelignan has anti-inflammatory effects on Th2 cell-mediated allergic lung inflammation and could potentially provide a novel preventative and/or therapy for the treatment of allergic diseases. |
| doi_str_mv | 10.1016/j.lfs.2013.04.010 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1356391874</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S002432051300235X</els_id><sourcerecordid>1356391874</sourcerecordid><originalsourceid>FETCH-LOGICAL-c377t-4e36a80f5073d6cdaed068f89c0348944266762aca8930ce7c774fd31da3cd1e3</originalsourceid><addsrcrecordid>eNp9kMFu1DAQhi0EotvCA3CBHLkkjGPHTsQJVUCRWnFoe7YGe7L1KnEW2yndt8dlC0dOc5jv_zXzMfaGQ8OBqw-7ZhpT0wIXDcgGODxjG97roQYl-HO2AWhlLVroTthpSjsA6DotXrKTVigplGg3LFyhpclvA4YKc6awYiZX4TRR3HpbTWvYVj6ME84zZr8UKpS1j7_wUN0d9hTrSGm_hOTvKVBKBa7mNfpAFT2UtZ8pZJwqTPluxlfsxYhTotdP84zdfvl8c35RX37_-u3802Vthda5liQU9jB2oIVT1iE5UP3YDxaE7AcpW6W0atFiPwiwpK3WcnSCOxTWcRJn7P2xdx-XnyulbGafyqMTBlrWZLjolBiKK1lQfkRtXFKKNJp9ORrjwXAwj5rNzhTN5lGzAWmK5pJ5-1S__pjJ_Uv89VqAd0dgxMXgNvpkbq9LQwelsNd_iI9HgoqGe0_RJOspWHI-ks3GLf4_B_wGluOZFA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1356391874</pqid></control><display><type>article</type><title>Macelignan attenuated allergic lung inflammation and airway hyper-responsiveness in murine experimental asthma</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Shin, Kihyuk ; Chung, Hee-chul ; Kim, Do-Un ; Hwang, Jae-Kwan ; Lee, Seung-Hyo</creator><creatorcontrib>Shin, Kihyuk ; Chung, Hee-chul ; Kim, Do-Un ; Hwang, Jae-Kwan ; Lee, Seung-Hyo</creatorcontrib><description>Macelignan isolated from Myristica fragrans Houtt. is widely used for spice and flavoring for foods, and has been reported to have anti-inflammatory activity. The aim of this study was to investigate the effects of macelignan on allergic lung inflammation with a murine model of experimental asthma.
Fungal protease mixed with chicken egg ovalbumin allergen was used as a challenge to induce murine experimental asthma. To determine its effects on allergy and inflammation, macelignan was administered orally during allergen challenge, and the symptoms of allergic asthma and its underlined mechanisms were examined.
Treatment with macelignan attenuated eosinophilic airway inflammation and airway hyper-responsiveness. With the administration of macelignan, interleukin-4 (IL-4) producing cells, but not interferon-γ (IFN-γ) or IL-17 producing cells, were diminished in the lungs. Additionally, activation of the T helper type 2 (Th2) cell-specific master transcription factor, GATA3 was decreased with macelignan treatment. Finally, production of IL-4 but not IFN-γ or IL-17, by CD4+ T cells was reduced with stimulation when combined with the administration of macelignan.
Our data show that macelignan has anti-inflammatory effects on Th2 cell-mediated allergic lung inflammation and could potentially provide a novel preventative and/or therapy for the treatment of allergic diseases.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2013.04.010</identifier><identifier>PMID: 23643632</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>allergens ; animal models ; Animals ; anti-inflammatory activity ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Asthma ; Asthma - chemically induced ; Asthma - drug therapy ; Asthma - physiopathology ; Bronchial Hyperreactivity - chemically induced ; Bronchial Hyperreactivity - drug therapy ; Bronchial Hyperreactivity - physiopathology ; CD4-positive T-lymphocytes ; CD4-Positive T-Lymphocytes - drug effects ; CD4-Positive T-Lymphocytes - metabolism ; chickens ; Disease Models, Animal ; eggs ; Female ; foods ; fungi ; GATA-3 ; GATA3 Transcription Factor - metabolism ; hypersensitivity ; Inflammation ; interferon-gamma ; interleukin-17 ; interleukin-4 ; Interleukin-4 - metabolism ; Lignans - pharmacology ; lungs ; Macelignan ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Myristica fragrans ; Myristica fragrans - chemistry ; oral administration ; ovalbumin ; Plant Extracts - pharmacology ; pneumonia ; proteinases ; spices ; Th2 cells ; Th2 Cells - drug effects ; Th2 Cells - metabolism ; therapeutics ; transcription factors</subject><ispartof>Life sciences (1973), 2013-06, Vol.92 (22), p.1093-1099</ispartof><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-4e36a80f5073d6cdaed068f89c0348944266762aca8930ce7c774fd31da3cd1e3</citedby><cites>FETCH-LOGICAL-c377t-4e36a80f5073d6cdaed068f89c0348944266762aca8930ce7c774fd31da3cd1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.lfs.2013.04.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23643632$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shin, Kihyuk</creatorcontrib><creatorcontrib>Chung, Hee-chul</creatorcontrib><creatorcontrib>Kim, Do-Un</creatorcontrib><creatorcontrib>Hwang, Jae-Kwan</creatorcontrib><creatorcontrib>Lee, Seung-Hyo</creatorcontrib><title>Macelignan attenuated allergic lung inflammation and airway hyper-responsiveness in murine experimental asthma</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Macelignan isolated from Myristica fragrans Houtt. is widely used for spice and flavoring for foods, and has been reported to have anti-inflammatory activity. The aim of this study was to investigate the effects of macelignan on allergic lung inflammation with a murine model of experimental asthma.
Fungal protease mixed with chicken egg ovalbumin allergen was used as a challenge to induce murine experimental asthma. To determine its effects on allergy and inflammation, macelignan was administered orally during allergen challenge, and the symptoms of allergic asthma and its underlined mechanisms were examined.
Treatment with macelignan attenuated eosinophilic airway inflammation and airway hyper-responsiveness. With the administration of macelignan, interleukin-4 (IL-4) producing cells, but not interferon-γ (IFN-γ) or IL-17 producing cells, were diminished in the lungs. Additionally, activation of the T helper type 2 (Th2) cell-specific master transcription factor, GATA3 was decreased with macelignan treatment. Finally, production of IL-4 but not IFN-γ or IL-17, by CD4+ T cells was reduced with stimulation when combined with the administration of macelignan.
Our data show that macelignan has anti-inflammatory effects on Th2 cell-mediated allergic lung inflammation and could potentially provide a novel preventative and/or therapy for the treatment of allergic diseases.</description><subject>allergens</subject><subject>animal models</subject><subject>Animals</subject><subject>anti-inflammatory activity</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Asthma</subject><subject>Asthma - chemically induced</subject><subject>Asthma - drug therapy</subject><subject>Asthma - physiopathology</subject><subject>Bronchial Hyperreactivity - chemically induced</subject><subject>Bronchial Hyperreactivity - drug therapy</subject><subject>Bronchial Hyperreactivity - physiopathology</subject><subject>CD4-positive T-lymphocytes</subject><subject>CD4-Positive T-Lymphocytes - drug effects</subject><subject>CD4-Positive T-Lymphocytes - metabolism</subject><subject>chickens</subject><subject>Disease Models, Animal</subject><subject>eggs</subject><subject>Female</subject><subject>foods</subject><subject>fungi</subject><subject>GATA-3</subject><subject>GATA3 Transcription Factor - metabolism</subject><subject>hypersensitivity</subject><subject>Inflammation</subject><subject>interferon-gamma</subject><subject>interleukin-17</subject><subject>interleukin-4</subject><subject>Interleukin-4 - metabolism</subject><subject>Lignans - pharmacology</subject><subject>lungs</subject><subject>Macelignan</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Transgenic</subject><subject>Myristica fragrans</subject><subject>Myristica fragrans - chemistry</subject><subject>oral administration</subject><subject>ovalbumin</subject><subject>Plant Extracts - pharmacology</subject><subject>pneumonia</subject><subject>proteinases</subject><subject>spices</subject><subject>Th2 cells</subject><subject>Th2 Cells - drug effects</subject><subject>Th2 Cells - metabolism</subject><subject>therapeutics</subject><subject>transcription factors</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAQhi0EotvCA3CBHLkkjGPHTsQJVUCRWnFoe7YGe7L1KnEW2yndt8dlC0dOc5jv_zXzMfaGQ8OBqw-7ZhpT0wIXDcgGODxjG97roQYl-HO2AWhlLVroTthpSjsA6DotXrKTVigplGg3LFyhpclvA4YKc6awYiZX4TRR3HpbTWvYVj6ME84zZr8UKpS1j7_wUN0d9hTrSGm_hOTvKVBKBa7mNfpAFT2UtZ8pZJwqTPluxlfsxYhTotdP84zdfvl8c35RX37_-u3802Vthda5liQU9jB2oIVT1iE5UP3YDxaE7AcpW6W0atFiPwiwpK3WcnSCOxTWcRJn7P2xdx-XnyulbGafyqMTBlrWZLjolBiKK1lQfkRtXFKKNJp9ORrjwXAwj5rNzhTN5lGzAWmK5pJ5-1S__pjJ_Uv89VqAd0dgxMXgNvpkbq9LQwelsNd_iI9HgoqGe0_RJOspWHI-ks3GLf4_B_wGluOZFA</recordid><startdate>20130613</startdate><enddate>20130613</enddate><creator>Shin, Kihyuk</creator><creator>Chung, Hee-chul</creator><creator>Kim, Do-Un</creator><creator>Hwang, Jae-Kwan</creator><creator>Lee, Seung-Hyo</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130613</creationdate><title>Macelignan attenuated allergic lung inflammation and airway hyper-responsiveness in murine experimental asthma</title><author>Shin, Kihyuk ; Chung, Hee-chul ; Kim, Do-Un ; Hwang, Jae-Kwan ; Lee, Seung-Hyo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-4e36a80f5073d6cdaed068f89c0348944266762aca8930ce7c774fd31da3cd1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>allergens</topic><topic>animal models</topic><topic>Animals</topic><topic>anti-inflammatory activity</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Asthma</topic><topic>Asthma - chemically induced</topic><topic>Asthma - drug therapy</topic><topic>Asthma - physiopathology</topic><topic>Bronchial Hyperreactivity - chemically induced</topic><topic>Bronchial Hyperreactivity - drug therapy</topic><topic>Bronchial Hyperreactivity - physiopathology</topic><topic>CD4-positive T-lymphocytes</topic><topic>CD4-Positive T-Lymphocytes - drug effects</topic><topic>CD4-Positive T-Lymphocytes - metabolism</topic><topic>chickens</topic><topic>Disease Models, Animal</topic><topic>eggs</topic><topic>Female</topic><topic>foods</topic><topic>fungi</topic><topic>GATA-3</topic><topic>GATA3 Transcription Factor - metabolism</topic><topic>hypersensitivity</topic><topic>Inflammation</topic><topic>interferon-gamma</topic><topic>interleukin-17</topic><topic>interleukin-4</topic><topic>Interleukin-4 - metabolism</topic><topic>Lignans - pharmacology</topic><topic>lungs</topic><topic>Macelignan</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Transgenic</topic><topic>Myristica fragrans</topic><topic>Myristica fragrans - chemistry</topic><topic>oral administration</topic><topic>ovalbumin</topic><topic>Plant Extracts - pharmacology</topic><topic>pneumonia</topic><topic>proteinases</topic><topic>spices</topic><topic>Th2 cells</topic><topic>Th2 Cells - drug effects</topic><topic>Th2 Cells - metabolism</topic><topic>therapeutics</topic><topic>transcription factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shin, Kihyuk</creatorcontrib><creatorcontrib>Chung, Hee-chul</creatorcontrib><creatorcontrib>Kim, Do-Un</creatorcontrib><creatorcontrib>Hwang, Jae-Kwan</creatorcontrib><creatorcontrib>Lee, Seung-Hyo</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shin, Kihyuk</au><au>Chung, Hee-chul</au><au>Kim, Do-Un</au><au>Hwang, Jae-Kwan</au><au>Lee, Seung-Hyo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Macelignan attenuated allergic lung inflammation and airway hyper-responsiveness in murine experimental asthma</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2013-06-13</date><risdate>2013</risdate><volume>92</volume><issue>22</issue><spage>1093</spage><epage>1099</epage><pages>1093-1099</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Macelignan isolated from Myristica fragrans Houtt. is widely used for spice and flavoring for foods, and has been reported to have anti-inflammatory activity. The aim of this study was to investigate the effects of macelignan on allergic lung inflammation with a murine model of experimental asthma.
Fungal protease mixed with chicken egg ovalbumin allergen was used as a challenge to induce murine experimental asthma. To determine its effects on allergy and inflammation, macelignan was administered orally during allergen challenge, and the symptoms of allergic asthma and its underlined mechanisms were examined.
Treatment with macelignan attenuated eosinophilic airway inflammation and airway hyper-responsiveness. With the administration of macelignan, interleukin-4 (IL-4) producing cells, but not interferon-γ (IFN-γ) or IL-17 producing cells, were diminished in the lungs. Additionally, activation of the T helper type 2 (Th2) cell-specific master transcription factor, GATA3 was decreased with macelignan treatment. Finally, production of IL-4 but not IFN-γ or IL-17, by CD4+ T cells was reduced with stimulation when combined with the administration of macelignan.
Our data show that macelignan has anti-inflammatory effects on Th2 cell-mediated allergic lung inflammation and could potentially provide a novel preventative and/or therapy for the treatment of allergic diseases.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>23643632</pmid><doi>10.1016/j.lfs.2013.04.010</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 2013-06, Vol.92 (22), p.1093-1099 |
| issn | 0024-3205 1879-0631 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1356391874 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | allergens animal models Animals anti-inflammatory activity Anti-Inflammatory Agents, Non-Steroidal - pharmacology Asthma Asthma - chemically induced Asthma - drug therapy Asthma - physiopathology Bronchial Hyperreactivity - chemically induced Bronchial Hyperreactivity - drug therapy Bronchial Hyperreactivity - physiopathology CD4-positive T-lymphocytes CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - metabolism chickens Disease Models, Animal eggs Female foods fungi GATA-3 GATA3 Transcription Factor - metabolism hypersensitivity Inflammation interferon-gamma interleukin-17 interleukin-4 Interleukin-4 - metabolism Lignans - pharmacology lungs Macelignan Mice Mice, Inbred C57BL Mice, Transgenic Myristica fragrans Myristica fragrans - chemistry oral administration ovalbumin Plant Extracts - pharmacology pneumonia proteinases spices Th2 cells Th2 Cells - drug effects Th2 Cells - metabolism therapeutics transcription factors |
| title | Macelignan attenuated allergic lung inflammation and airway hyper-responsiveness in murine experimental asthma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T01%3A21%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Macelignan%20attenuated%20allergic%20lung%20inflammation%20and%20airway%20hyper-responsiveness%20in%20murine%20experimental%20asthma&rft.jtitle=Life%20sciences%20(1973)&rft.au=Shin,%20Kihyuk&rft.date=2013-06-13&rft.volume=92&rft.issue=22&rft.spage=1093&rft.epage=1099&rft.pages=1093-1099&rft.issn=0024-3205&rft.eissn=1879-0631&rft_id=info:doi/10.1016/j.lfs.2013.04.010&rft_dat=%3Cproquest_cross%3E1356391874%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1356391874&rft_id=info:pmid/23643632&rft_els_id=S002432051300235X&rfr_iscdi=true |