The expression and functional activity of membrane-bound human leukocyte antigen-G1 are influenced by the 3′-untranslated region

Abstract Human Leukocyte Antigen (HLA)-G is an immunosuppressive molecule acting on both the innate and adaptive immune system. A 14 bp insertion/deletion polymorphism (rs66554220) in the 3′-untranslated region (3′UTR) of the HLA-G gene has been associated with a number of diseases, pregnancy compli...

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Veröffentlicht in:	Human immunology 2013-07, Vol.74 (7), p.818-827
Hauptverfasser:	Svendsen, Signe Goul, Hantash, Basil M, Zhao, Longmei, Faber, Carsten, Bzorek, Michael, Nissen, Mogens Holst, Hviid, Thomas Vauvert F
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics 3' Untranslated Regions - physiology Allergy and Immunology Antigen Presentation - genetics Cytotoxicity, Immunologic - genetics Gene Expression Regulation Genetic Predisposition to Disease HLA-G Antigens - genetics Humans Immune Tolerance - genetics INDEL Mutation - genetics K562 Cells Polymorphism, Genetic Protein Stability Transgenes - genetics
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