Toll-Like Receptor-2 Plays a Fundamental Role in Periodontal Bacteria-Accelerated Abdominal Aortic Aneurysms

Background: Periodontopathic bacteria are detected at a high rate in specimens obtained from the aortic walls of patients with abdominal aortic aneurysm (AAA) and are involved in AAA development. The purpose of this study was to clarify the role of Toll-like receptors (TLRs), which are key receptors...

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Veröffentlicht in:	Circulation Journal 2013, Vol.77(6), pp.1565-1573
Hauptverfasser:	Aoyama, Norio, Suzuki, Jun-ichi, Ogawa, Masahito, Watanabe, Ryo, Kobayashi, Naho, Hanatani, Tomoya, Ashigaki, Norihiko, Sekinishi, Asuka, Izumi, Yuichi, Isobe, Mitsuaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneurysm Animals Aorta, Abdominal - immunology Aorta, Abdominal - microbiology Aorta, Abdominal - pathology Aortic Aneurysm, Abdominal - genetics Aortic Aneurysm, Abdominal - immunology Aortic Aneurysm, Abdominal - microbiology Aortic Aneurysm, Abdominal - pathology Bacteroidaceae Infections - genetics Bacteroidaceae Infections - immunology Bacteroidaceae Infections - pathology Humans Inflammation Matrix metalloproteinase Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - immunology Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - immunology Mice Mice, Knockout Periodontium - immunology Periodontium - microbiology Periodontium - pathology Porphyromonas gingivalis Porphyromonas gingivalis - immunology Signal Transduction - genetics Signal Transduction - immunology Toll-like receptor Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - immunology Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - immunology
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