Malt1-Induced Cleavage of Regnase-1 in CD4+ Helper T Cells Regulates Immune Activation

Regnase-1 (also known as Zc3h12a and MCPIP1) is an RNase that destabilizes a set of mRNAs, including Il6 and Il12b, through cleavage of their 3′ UTRs. Although Regnase-1 inactivation leads to development of an autoimmune disease characterized by T cell activation and hyperimmunoglobulinemia in mice,...

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Veröffentlicht in:	Cell 2013-05, Vol.153 (5), p.1036-1049
Hauptverfasser:	Uehata, Takuya, Iwasaki, Hidenori, Vandenbon, Alexis, Matsushita, Kazufumi, Hernandez-Cuellar, Eduardo, Kuniyoshi, Kanako, Satoh, Takashi, Mino, Takashi, Suzuki, Yutaka, Standley, Daron M., Tsujimura, Tohru, Rakugi, Hiromi, Isaka, Yoshitaka, Takeuchi, Osamu, Akira, Shizuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals autoimmune diseases Autoimmune Diseases - immunology Caspases - metabolism CD4-positive T-lymphocytes enzyme activity genes Humans hypergammaglobulinemia interleukin-2 Interleukin-2 - genetics interleukin-6 Jurkat Cells Lymphocyte Activation Membrane Glycoproteins - genetics messenger RNA Mice Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein Neoplasm Proteins - metabolism Proto-Oncogene Proteins c-rel - genetics Receptors, Antigen, T-Cell - metabolism ribonucleases Ribonucleases - metabolism T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism Tumor Necrosis Factors - genetics
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