miR-135b Coordinates Progression of ErbB2-Driven Mammary Carcinomas through Suppression of MID1 and MTCH2

In an attempt to reveal deregulated miRNAs associated with the progression of carcinomas developed in BALB-neuT transgenic mice, we found increased expression of miR-135b during malignancy. Relevantly, we observed that miR-135b is up-regulated in basal or normal-like human breast cancers, and it cor...

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Veröffentlicht in:	The American journal of pathology 2013-06, Vol.182 (6), p.2058-2070
Hauptverfasser:	Arigoni, Maddalena, Barutello, Giuseppina, Riccardo, Federica, Ercole, Elisabetta, Cantarella, Daniela, Orso, Francesca, Conti, Laura, Lanzardo, Stefania, Taverna, Daniela, Merighi, Irene, Calogero, Raffaele A, Cavallo, Federica, Quaglino, Elena
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast Neoplasms - metabolism Cell Proliferation Disease Progression Female Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic - physiology Genes, erbB-2 Humans Lung Neoplasms - metabolism Lung Neoplasms - secondary Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - pathology Mice Mice, Inbred BALB C Mice, Transgenic MicroRNAs - biosynthesis MicroRNAs - genetics MicroRNAs - physiology Mitochondrial Membrane Transport Proteins - metabolism Neoplasm Invasiveness Neoplasm Proteins - metabolism Neoplastic Stem Cells - metabolism Pathology Proteins - metabolism RNA, Neoplasm - genetics Tumor Cells, Cultured Up-Regulation - physiology
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