Quantifying the importance of pMHC valency, total pMHC dose and frequency on nanoparticle therapeutic efficacy

Nanoparticles (NPs) coated with β‐cell‐specific peptide major histocompatibility complex (pMHC) class I molecules can effectively restore normoglycemia in spontaneously diabetic nonobese diabetic mice. They do so by expanding pools of cognate memory autoreactive regulatory CD8+ T cells that arise fr...

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Veröffentlicht in:	Immunology and cell biology 2013-05, Vol.91 (5), p.350-359
Hauptverfasser:	Sugarman, Jordan, Tsai, Sue, Santamaria, Pere, Khadra, Anmar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantigens - administration & dosage Autoimmune Diseases - therapy autoregulatory T cells bifurcation analysis biphasic response CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Clinical Protocols Computational Biology Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - therapy Drug Design Histocompatibility Antigens Class I - immunology Histocompatibility Antigens Class I - therapeutic use Humans Hyperglycemia - drug therapy Hyperglycemia - immunology Insulin-Secreting Cells - immunology mathematical model Mice Mice, Inbred NOD Models, Theoretical Nanoparticles - administration & dosage Nanoparticles - chemistry Peptide Fragments - immunology Peptide Fragments - therapeutic use population of model mice T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology T‐cell avidity
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