The Fractional Exhaled Nitric Oxide and Serum High Sensitivity C-Reactive Protein Levels in Cough Variant Asthma and Typical Bronchial Asthma
Fractional exhaled nitric oxide (FeNO) is known to be a good marker of airway eosinophilic inflammation in bronchial asthma. Recently, serum high sensitivity C-reactive protein (hs-CRP) has been shown to be also useful to detect the airway inflammation. Newly diagnosed 90 cough variant asthma and 92...
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| Veröffentlicht in: | Allergology International 2013, Vol.62 (2), p.251-257 |
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| creator | Shimoda, Terufumi Obase, Yasushi Kishikawa, Reiko Iwanaga, Tomoaki Miyatake, Akihiko Kasayama, Soji |
| description | Fractional exhaled nitric oxide (FeNO) is known to be a good marker of airway eosinophilic inflammation in bronchial asthma. Recently, serum high sensitivity C-reactive protein (hs-CRP) has been shown to be also useful to detect the airway inflammation.
Newly diagnosed 90 cough variant asthma and 92 bronchial asthma patients were enrolled. FeNO, serum hs-CRP, pulmonary function tests, bronchial hyperresponsiveness, IgE and sputum eosinophils ratio were compared. Ninety healthy control subjects were set for FeNO and serum hs-CRP normal range reference. We have compared the clinical utilities of FeNO and serum hs-CRP to differentiate bronchial asthma and cough variant asthma.
FeNO was significantly higher in bronchial asthma (92.6±85.5ppb) than in cough variant asthma (35.6±43.3; p |
| doi_str_mv | 10.2332/allergolint.12-OA-0515 |
| format | Article |
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Newly diagnosed 90 cough variant asthma and 92 bronchial asthma patients were enrolled. FeNO, serum hs-CRP, pulmonary function tests, bronchial hyperresponsiveness, IgE and sputum eosinophils ratio were compared. Ninety healthy control subjects were set for FeNO and serum hs-CRP normal range reference. We have compared the clinical utilities of FeNO and serum hs-CRP to differentiate bronchial asthma and cough variant asthma.
FeNO was significantly higher in bronchial asthma (92.6±85.5ppb) than in cough variant asthma (35.6±43.3; p<0.001) and both were significantly higher than normal range (18.0±6.4, p<0.001, respectively), and in differentiating between the two groups showed a sensitivity of 0.69 and a specificity of 0.73 at the cutoff value of 28ppb. Serum hs-CRP did not differ significantly between bronchial asthma (723±1162ng/ml) and cough variant asthma (558±758) even if both were significantly higher than normal range (345±401, p<0.01 and p<0.05 respectively).
FeNO is more useful than serum hs-CRP in differentiating patients with bronchial asthma from those with cough variant asthma, and healthy persons.</description><identifier>ISSN: 1323-8930</identifier><identifier>EISSN: 1440-1592</identifier><identifier>DOI: 10.2332/allergolint.12-OA-0515</identifier><identifier>PMID: 23612495</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Adult ; airway inflammation ; Asthma - metabolism ; Asthma - physiopathology ; bronchial asthma ; Bronchial Hyperreactivity ; Bronchial Provocation Tests ; C-Reactive Protein - analysis ; Cough ; cough variant asthma ; Eosinophils - metabolism ; Exhalation ; Female ; fractional exhaled nitric oxide ; high sensitivity CRP ; Humans ; Male ; Middle Aged ; Nitric Oxide - metabolism ; Respiratory Function Tests ; Sputum - metabolism</subject><ispartof>Allergology International, 2013, Vol.62 (2), p.251-257</ispartof><rights>2013 Japanese Society of Allergology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c671t-2ab577b55493cff39a429437665f72b93f89b97973b2603f15d790ca5c55214c3</citedby><cites>FETCH-LOGICAL-c671t-2ab577b55493cff39a429437665f72b93f89b97973b2603f15d790ca5c55214c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23612495$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shimoda, Terufumi</creatorcontrib><creatorcontrib>Obase, Yasushi</creatorcontrib><creatorcontrib>Kishikawa, Reiko</creatorcontrib><creatorcontrib>Iwanaga, Tomoaki</creatorcontrib><creatorcontrib>Miyatake, Akihiko</creatorcontrib><creatorcontrib>Kasayama, Soji</creatorcontrib><creatorcontrib>Clinical Research Center</creatorcontrib><creatorcontrib>Miyatake Asthma Clinic</creatorcontrib><creatorcontrib>Nissay Hospital</creatorcontrib><creatorcontrib>Kawasaki Medical School</creatorcontrib><creatorcontrib>Department of Respiratory Medicine</creatorcontrib><creatorcontrib>Fukuoka National Hospital</creatorcontrib><creatorcontrib>Department of Internal Medicine</creatorcontrib><title>The Fractional Exhaled Nitric Oxide and Serum High Sensitivity C-Reactive Protein Levels in Cough Variant Asthma and Typical Bronchial Asthma</title><title>Allergology International</title><addtitle>Allergol Int</addtitle><description>Fractional exhaled nitric oxide (FeNO) is known to be a good marker of airway eosinophilic inflammation in bronchial asthma. Recently, serum high sensitivity C-reactive protein (hs-CRP) has been shown to be also useful to detect the airway inflammation.
Newly diagnosed 90 cough variant asthma and 92 bronchial asthma patients were enrolled. FeNO, serum hs-CRP, pulmonary function tests, bronchial hyperresponsiveness, IgE and sputum eosinophils ratio were compared. Ninety healthy control subjects were set for FeNO and serum hs-CRP normal range reference. We have compared the clinical utilities of FeNO and serum hs-CRP to differentiate bronchial asthma and cough variant asthma.
FeNO was significantly higher in bronchial asthma (92.6±85.5ppb) than in cough variant asthma (35.6±43.3; p<0.001) and both were significantly higher than normal range (18.0±6.4, p<0.001, respectively), and in differentiating between the two groups showed a sensitivity of 0.69 and a specificity of 0.73 at the cutoff value of 28ppb. Serum hs-CRP did not differ significantly between bronchial asthma (723±1162ng/ml) and cough variant asthma (558±758) even if both were significantly higher than normal range (345±401, p<0.01 and p<0.05 respectively).
FeNO is more useful than serum hs-CRP in differentiating patients with bronchial asthma from those with cough variant asthma, and healthy persons.</description><subject>Adult</subject><subject>airway inflammation</subject><subject>Asthma - metabolism</subject><subject>Asthma - physiopathology</subject><subject>bronchial asthma</subject><subject>Bronchial Hyperreactivity</subject><subject>Bronchial Provocation Tests</subject><subject>C-Reactive Protein - analysis</subject><subject>Cough</subject><subject>cough variant asthma</subject><subject>Eosinophils - metabolism</subject><subject>Exhalation</subject><subject>Female</subject><subject>fractional exhaled nitric oxide</subject><subject>high sensitivity CRP</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nitric Oxide - metabolism</subject><subject>Respiratory Function Tests</subject><subject>Sputum - metabolism</subject><issn>1323-8930</issn><issn>1440-1592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2O0zAUhSMEYoaBVxh5ySaDf2Kn3lGq-UGqKILC1nKcm6lHiV1sp0wfgnfGaQbEjo19ZJ_7Xfueorgk-IoyRt_pvodw73vr0hWh5WZZYk74s-KcVBUuCZf0edaMsnIhGT4rXsX4gDGhtaxfFmeUCUIryc-LX9sdoJugTbLe6R5dP-50Dy36ZFOwBm0ebQtIuxZ9hTAO6M7e77J00SZ7sOmIVuUXmIoPgD4Hn8A6tIYD9BFltfJjtn_XwWqX0DKm3aBPsO1xb03u9iF4Z3Y2q_nydfGi032EN0_7RfHt5nq7uivXm9uPq-W6NKImqaS64XXdcF5JZrqOSV1RWbFaCN7VtJGsW8hG5q-yhgrMOsLbWmKjueGcksqwi-LtzN0H_2OEmNRgo4G-1w78GBVhXDAhuVhkq5itJvgYA3RqH-ygw1ERrKYo1D9RKELVZqmmKHLh5VOPsRmg_Vv2Z_bZcDsb8u00De8yAtSDH0NOIirzs9InKMWEKYwFxVSdJOVkWup8sKilyKT3MynPHQ4WgorGgjOZG8Ak1Xr7v9f-Bi5CtcE</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Shimoda, Terufumi</creator><creator>Obase, Yasushi</creator><creator>Kishikawa, Reiko</creator><creator>Iwanaga, Tomoaki</creator><creator>Miyatake, Akihiko</creator><creator>Kasayama, Soji</creator><general>Elsevier B.V</general><general>JAPANESE SOCIETY OF ALLERGOLOGY</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2013</creationdate><title>The Fractional Exhaled Nitric Oxide and Serum High Sensitivity C-Reactive Protein Levels in Cough Variant Asthma and Typical Bronchial Asthma</title><author>Shimoda, Terufumi ; Obase, Yasushi ; Kishikawa, Reiko ; Iwanaga, Tomoaki ; Miyatake, Akihiko ; Kasayama, Soji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c671t-2ab577b55493cff39a429437665f72b93f89b97973b2603f15d790ca5c55214c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>airway inflammation</topic><topic>Asthma - metabolism</topic><topic>Asthma - physiopathology</topic><topic>bronchial asthma</topic><topic>Bronchial Hyperreactivity</topic><topic>Bronchial Provocation Tests</topic><topic>C-Reactive Protein - analysis</topic><topic>Cough</topic><topic>cough variant asthma</topic><topic>Eosinophils - metabolism</topic><topic>Exhalation</topic><topic>Female</topic><topic>fractional exhaled nitric oxide</topic><topic>high sensitivity CRP</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nitric Oxide - metabolism</topic><topic>Respiratory Function Tests</topic><topic>Sputum - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shimoda, Terufumi</creatorcontrib><creatorcontrib>Obase, Yasushi</creatorcontrib><creatorcontrib>Kishikawa, Reiko</creatorcontrib><creatorcontrib>Iwanaga, Tomoaki</creatorcontrib><creatorcontrib>Miyatake, Akihiko</creatorcontrib><creatorcontrib>Kasayama, Soji</creatorcontrib><creatorcontrib>Clinical Research Center</creatorcontrib><creatorcontrib>Miyatake Asthma Clinic</creatorcontrib><creatorcontrib>Nissay Hospital</creatorcontrib><creatorcontrib>Kawasaki Medical School</creatorcontrib><creatorcontrib>Department of Respiratory Medicine</creatorcontrib><creatorcontrib>Fukuoka National Hospital</creatorcontrib><creatorcontrib>Department of Internal Medicine</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Allergology International</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimoda, Terufumi</au><au>Obase, Yasushi</au><au>Kishikawa, Reiko</au><au>Iwanaga, Tomoaki</au><au>Miyatake, Akihiko</au><au>Kasayama, Soji</au><aucorp>Clinical Research Center</aucorp><aucorp>Miyatake Asthma Clinic</aucorp><aucorp>Nissay Hospital</aucorp><aucorp>Kawasaki Medical School</aucorp><aucorp>Department of Respiratory Medicine</aucorp><aucorp>Fukuoka National Hospital</aucorp><aucorp>Department of Internal Medicine</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Fractional Exhaled Nitric Oxide and Serum High Sensitivity C-Reactive Protein Levels in Cough Variant Asthma and Typical Bronchial Asthma</atitle><jtitle>Allergology International</jtitle><addtitle>Allergol Int</addtitle><date>2013</date><risdate>2013</risdate><volume>62</volume><issue>2</issue><spage>251</spage><epage>257</epage><pages>251-257</pages><issn>1323-8930</issn><eissn>1440-1592</eissn><abstract>Fractional exhaled nitric oxide (FeNO) is known to be a good marker of airway eosinophilic inflammation in bronchial asthma. Recently, serum high sensitivity C-reactive protein (hs-CRP) has been shown to be also useful to detect the airway inflammation.
Newly diagnosed 90 cough variant asthma and 92 bronchial asthma patients were enrolled. FeNO, serum hs-CRP, pulmonary function tests, bronchial hyperresponsiveness, IgE and sputum eosinophils ratio were compared. Ninety healthy control subjects were set for FeNO and serum hs-CRP normal range reference. We have compared the clinical utilities of FeNO and serum hs-CRP to differentiate bronchial asthma and cough variant asthma.
FeNO was significantly higher in bronchial asthma (92.6±85.5ppb) than in cough variant asthma (35.6±43.3; p<0.001) and both were significantly higher than normal range (18.0±6.4, p<0.001, respectively), and in differentiating between the two groups showed a sensitivity of 0.69 and a specificity of 0.73 at the cutoff value of 28ppb. Serum hs-CRP did not differ significantly between bronchial asthma (723±1162ng/ml) and cough variant asthma (558±758) even if both were significantly higher than normal range (345±401, p<0.01 and p<0.05 respectively).
FeNO is more useful than serum hs-CRP in differentiating patients with bronchial asthma from those with cough variant asthma, and healthy persons.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>23612495</pmid><doi>10.2332/allergolint.12-OA-0515</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Allergology International, 2013, Vol.62 (2), p.251-257 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Open Access Titles of Japan |
| subjects | Adult airway inflammation Asthma - metabolism Asthma - physiopathology bronchial asthma Bronchial Hyperreactivity Bronchial Provocation Tests C-Reactive Protein - analysis Cough cough variant asthma Eosinophils - metabolism Exhalation Female fractional exhaled nitric oxide high sensitivity CRP Humans Male Middle Aged Nitric Oxide - metabolism Respiratory Function Tests Sputum - metabolism |
| title | The Fractional Exhaled Nitric Oxide and Serum High Sensitivity C-Reactive Protein Levels in Cough Variant Asthma and Typical Bronchial Asthma |
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