Polymorphisms of Receptor for Advanced Glycation end Products and Risk of Epithelial Ovarian Cancer in Chinese Patients
Background: Given the roles of receptor for advanced glycation end products (RAGE) in the pathogenesis of carcinogenesis, we propose that RAGE polymorphisms may be associated with risk of epithelial ovarian carcinoma (EOC). Method: This case-control study included 190 women over 40 years of age who...
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| Veröffentlicht in: | Cellular physiology and biochemistry 2013-01, Vol.31 (4-5), p.525-531 |
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| creator | Zhang, Shuquan Hou, Xuwei Zi, Sihua Wang, Yankui Chen, Lijun Kong, Beihua |
| description | Background: Given the roles of receptor for advanced glycation end products (RAGE) in the pathogenesis of carcinogenesis, we propose that RAGE polymorphisms may be associated with risk of epithelial ovarian carcinoma (EOC). Method: This case-control study included 190 women over 40 years of age who were diagnosed with primary EOC and 210 healthy control subjects. RAGE gene polymorphisms, including 82G>S,-374T>A,-429C>T,and 1704G>T were determined. Results: We found that only the frequencies of the 82G>S polymorphisms were significantly different between the EOC cases and controls. The 82SS genotype was significantly higher in EOC patients than in controls (37.89% vs. 23.33%,PT,-374T>A and -429C>T did not affect the EOC risk. Conclusion: This result suggests that the 82G>S polymorphism of RAGE gene may be associated with the susceptibility of EOC. |
| doi_str_mv | 10.1159/000350073 |
| format | Article |
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Method: This case-control study included 190 women over 40 years of age who were diagnosed with primary EOC and 210 healthy control subjects. RAGE gene polymorphisms, including 82G>S,-374T>A,-429C>T,and 1704G>T were determined. Results: We found that only the frequencies of the 82G>S polymorphisms were significantly different between the EOC cases and controls. The 82SS genotype was significantly higher in EOC patients than in controls (37.89% vs. 23.33%,P<0.001). With the 82 GG genotype as reference, the OR for 82SS homozygous carriers reached to 2.65 (95% CI: 1.54-4.58; P =0.0004) after adjustment for age, smoking status, body mass index, family history, usage of contraceptives, tubal ligation history, use of menopausal hormones and menopausal status. The 82S allele carriage presented a higher risk for EOC (OR=1.71; 95% CI, 1.29-2.26; P=0.0002). The polymorphisms of 1704G>T,-374T>A and -429C>T did not affect the EOC risk. Conclusion: This result suggests that the 82G>S polymorphism of RAGE gene may be associated with the susceptibility of EOC.</description><identifier>ISSN: 1015-8987</identifier><identifier>EISSN: 1421-9778</identifier><identifier>DOI: 10.1159/000350073</identifier><identifier>PMID: 23571222</identifier><language>eng</language><publisher>Basel, Switzerland: Cell Physiol Biochem Press GmbH & Co KG</publisher><subject>Alleles ; Asian Continental Ancestry Group - genetics ; Carcinoma - etiology ; Carcinoma - genetics ; Carcinoma, Ovarian Epithelial ; Case-Control Studies ; China ; Epithelial ovarian carcinoma ; Female ; Gene Frequency ; Genotype ; Homozygote ; Humans ; Middle Aged ; Neoplasms, Glandular and Epithelial - etiology ; Neoplasms, Glandular and Epithelial - genetics ; Odds Ratio ; Original Paper ; Ovarian Neoplasms - etiology ; Ovarian Neoplasms - genetics ; Polymorphism, Genetic ; Polymorphisms ; Receptor for Advanced Glycation End Products ; Receptors, Immunologic - genetics ; Risk ; Risk Factors</subject><ispartof>Cellular physiology and biochemistry, 2013-01, Vol.31 (4-5), p.525-531</ispartof><rights>2013 S. Karger AG, Basel</rights><rights>Copyright © 2013 S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-965b070fb82e1d559253759886e97b85dc2c99006c815e36f6b3b867a1f0e0093</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,2096,27612,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23571222$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Shuquan</creatorcontrib><creatorcontrib>Hou, Xuwei</creatorcontrib><creatorcontrib>Zi, Sihua</creatorcontrib><creatorcontrib>Wang, Yankui</creatorcontrib><creatorcontrib>Chen, Lijun</creatorcontrib><creatorcontrib>Kong, Beihua</creatorcontrib><title>Polymorphisms of Receptor for Advanced Glycation end Products and Risk of Epithelial Ovarian Cancer in Chinese Patients</title><title>Cellular physiology and biochemistry</title><addtitle>Cell Physiol Biochem</addtitle><description>Background: Given the roles of receptor for advanced glycation end products (RAGE) in the pathogenesis of carcinogenesis, we propose that RAGE polymorphisms may be associated with risk of epithelial ovarian carcinoma (EOC). Method: This case-control study included 190 women over 40 years of age who were diagnosed with primary EOC and 210 healthy control subjects. RAGE gene polymorphisms, including 82G>S,-374T>A,-429C>T,and 1704G>T were determined. Results: We found that only the frequencies of the 82G>S polymorphisms were significantly different between the EOC cases and controls. The 82SS genotype was significantly higher in EOC patients than in controls (37.89% vs. 23.33%,P<0.001). With the 82 GG genotype as reference, the OR for 82SS homozygous carriers reached to 2.65 (95% CI: 1.54-4.58; P =0.0004) after adjustment for age, smoking status, body mass index, family history, usage of contraceptives, tubal ligation history, use of menopausal hormones and menopausal status. The 82S allele carriage presented a higher risk for EOC (OR=1.71; 95% CI, 1.29-2.26; P=0.0002). The polymorphisms of 1704G>T,-374T>A and -429C>T did not affect the EOC risk. Conclusion: This result suggests that the 82G>S polymorphism of RAGE gene may be associated with the susceptibility of EOC.</description><subject>Alleles</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Carcinoma - etiology</subject><subject>Carcinoma - genetics</subject><subject>Carcinoma, Ovarian Epithelial</subject><subject>Case-Control Studies</subject><subject>China</subject><subject>Epithelial ovarian carcinoma</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Homozygote</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Neoplasms, Glandular and Epithelial - etiology</subject><subject>Neoplasms, Glandular and Epithelial - genetics</subject><subject>Odds Ratio</subject><subject>Original Paper</subject><subject>Ovarian Neoplasms - etiology</subject><subject>Ovarian Neoplasms - genetics</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphisms</subject><subject>Receptor for Advanced Glycation End Products</subject><subject>Receptors, Immunologic - genetics</subject><subject>Risk</subject><subject>Risk Factors</subject><issn>1015-8987</issn><issn>1421-9778</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNptkc1v1DAQxSMEoqVw4I6QJS5wCPgj_jqWVSmVKnVVwdlynHHXbRIHO1u0_z1eUnLiMPKM5_eeJb-qekvwZ0K4_oIxZhxjyZ5Vp6ShpNZSquelx4TXSit5Ur3K-R6XUWr6sjqhjEtCKT2tfm9jfxhimnYhDxlFj27BwTTHhHyp8-7Rjg46dNkfnJ1DHBGMHdqm2O3dnJEtw23ID0fhxRTmHfTB9ujm0aZgR7Q5ihMKpduFETKgbTGBcc6vqxfe9hnePJ1n1c9vFz823-vrm8urzfl17RrG51oL3mKJfasokI5zTTmTXCslQMtW8c5RpzXGwinCgQkvWtYqIS3xGDDW7Ky6Wny7aO_NlMJg08FEG8zfi5jujE1zcD0YqVvRCCK8Ja5pOrDgWyg_Ba0mjHtZvD4uXlOKv_aQZzOE7KDv7Qhxn02hBBOaUlXQTwvqUsw5gV-fJtgcMzNrZoV9_2S7bwfoVvJfSAV4twAPNt1BWoFV_-G_683260KYqfPsDyBVpU4</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Zhang, Shuquan</creator><creator>Hou, Xuwei</creator><creator>Zi, Sihua</creator><creator>Wang, Yankui</creator><creator>Chen, Lijun</creator><creator>Kong, Beihua</creator><general>Cell Physiol Biochem Press GmbH & Co KG</general><scope>M--</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20130101</creationdate><title>Polymorphisms of Receptor for Advanced Glycation end Products and Risk of Epithelial Ovarian Cancer in Chinese Patients</title><author>Zhang, Shuquan ; Hou, Xuwei ; Zi, Sihua ; Wang, Yankui ; Chen, Lijun ; Kong, Beihua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-965b070fb82e1d559253759886e97b85dc2c99006c815e36f6b3b867a1f0e0093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Alleles</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Carcinoma - etiology</topic><topic>Carcinoma - genetics</topic><topic>Carcinoma, Ovarian Epithelial</topic><topic>Case-Control Studies</topic><topic>China</topic><topic>Epithelial ovarian carcinoma</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Homozygote</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Neoplasms, Glandular and Epithelial - etiology</topic><topic>Neoplasms, Glandular and Epithelial - genetics</topic><topic>Odds Ratio</topic><topic>Original Paper</topic><topic>Ovarian Neoplasms - etiology</topic><topic>Ovarian Neoplasms - genetics</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphisms</topic><topic>Receptor for Advanced Glycation End Products</topic><topic>Receptors, Immunologic - genetics</topic><topic>Risk</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Shuquan</creatorcontrib><creatorcontrib>Hou, Xuwei</creatorcontrib><creatorcontrib>Zi, Sihua</creatorcontrib><creatorcontrib>Wang, Yankui</creatorcontrib><creatorcontrib>Chen, Lijun</creatorcontrib><creatorcontrib>Kong, Beihua</creatorcontrib><collection>Karger Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Cellular physiology and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Shuquan</au><au>Hou, Xuwei</au><au>Zi, Sihua</au><au>Wang, Yankui</au><au>Chen, Lijun</au><au>Kong, Beihua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphisms of Receptor for Advanced Glycation end Products and Risk of Epithelial Ovarian Cancer in Chinese Patients</atitle><jtitle>Cellular physiology and biochemistry</jtitle><addtitle>Cell Physiol Biochem</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>31</volume><issue>4-5</issue><spage>525</spage><epage>531</epage><pages>525-531</pages><issn>1015-8987</issn><eissn>1421-9778</eissn><abstract>Background: Given the roles of receptor for advanced glycation end products (RAGE) in the pathogenesis of carcinogenesis, we propose that RAGE polymorphisms may be associated with risk of epithelial ovarian carcinoma (EOC). Method: This case-control study included 190 women over 40 years of age who were diagnosed with primary EOC and 210 healthy control subjects. RAGE gene polymorphisms, including 82G>S,-374T>A,-429C>T,and 1704G>T were determined. Results: We found that only the frequencies of the 82G>S polymorphisms were significantly different between the EOC cases and controls. The 82SS genotype was significantly higher in EOC patients than in controls (37.89% vs. 23.33%,P<0.001). With the 82 GG genotype as reference, the OR for 82SS homozygous carriers reached to 2.65 (95% CI: 1.54-4.58; P =0.0004) after adjustment for age, smoking status, body mass index, family history, usage of contraceptives, tubal ligation history, use of menopausal hormones and menopausal status. The 82S allele carriage presented a higher risk for EOC (OR=1.71; 95% CI, 1.29-2.26; P=0.0002). The polymorphisms of 1704G>T,-374T>A and -429C>T did not affect the EOC risk. Conclusion: This result suggests that the 82G>S polymorphism of RAGE gene may be associated with the susceptibility of EOC.</abstract><cop>Basel, Switzerland</cop><pub>Cell Physiol Biochem Press GmbH & Co KG</pub><pmid>23571222</pmid><doi>10.1159/000350073</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alleles Asian Continental Ancestry Group - genetics Carcinoma - etiology Carcinoma - genetics Carcinoma, Ovarian Epithelial Case-Control Studies China Epithelial ovarian carcinoma Female Gene Frequency Genotype Homozygote Humans Middle Aged Neoplasms, Glandular and Epithelial - etiology Neoplasms, Glandular and Epithelial - genetics Odds Ratio Original Paper Ovarian Neoplasms - etiology Ovarian Neoplasms - genetics Polymorphism, Genetic Polymorphisms Receptor for Advanced Glycation End Products Receptors, Immunologic - genetics Risk Risk Factors |
| title | Polymorphisms of Receptor for Advanced Glycation end Products and Risk of Epithelial Ovarian Cancer in Chinese Patients |
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