New azacannabinoids highly active in the central nervous system

Pursuit of the hypothesis that optimum central nervous system (CNS) activity in 2-azacannabinoids (I and II) requires a moderately basic nitrogen atom (pK = 5-7) has led to several very active alpha -amino amide derivatives, namely 10-hydroxy-N,5,5-trimethyl-8-(1,2-dimethylheptyl)-1,2,3,4-tetrahyd r...

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