Solid Organ Transplant Patients Experience High Rates of Infection and Other Complications After Total Knee Arthroplasty
Abstract Survival after solid organ transplants in the United States is increasing, and there is a need to understand the complications in knee arthroplasty patients who underwent organ transplantation. A retrospective study was conducted from 1993–2008 on 19 patients (23 knee arthroplasties) with p...
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| Veröffentlicht in: | The Journal of arthroplasty 2013-06, Vol.28 (6), p.960-963 |
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| container_title | The Journal of arthroplasty |
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| creator | Klatt, Brian A., MD Steele, G. Daxton, MD Fedorka, Catherine J., MD Sánchez, Alvaro I., MD/MS Chen, Antonia F., MD/MBA Crossett, Lawrence S., MD |
| description | Abstract Survival after solid organ transplants in the United States is increasing, and there is a need to understand the complications in knee arthroplasty patients who underwent organ transplantation. A retrospective study was conducted from 1993–2008 on 19 patients (23 knee arthroplasties) with previous successful solid organ transplants. Eleven knee arthroplasties were performed after renal transplantation, and 12 after nonrenal solid organ transplant (seven liver, four heart, one lung). Complications occurred in 9/23 patients (39.1%) and infections occurred in 4/23 patients (17.3%). Of the infected knees, two had MRSA, one had MSSA, and one Escherichia coli . Noninfectious complications (5/24, 21.7%) include aseptic loosening, quadriceps rupture, femoral fracture, hemarthrosis, and arthrofibrosis. All patients with complications were on immunosuppressant medications at the time of arthroplasty. There was a significantly higher rate of infection in the renal group compared to the non-renal group ( P = 0.022). There was also a higher overall complication rate in the renal group however this did not reach significance. |
| doi_str_mv | 10.1016/j.arth.2013.02.005 |
| format | Article |
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Daxton, MD ; Fedorka, Catherine J., MD ; Sánchez, Alvaro I., MD/MS ; Chen, Antonia F., MD/MBA ; Crossett, Lawrence S., MD</creator><creatorcontrib>Klatt, Brian A., MD ; Steele, G. Daxton, MD ; Fedorka, Catherine J., MD ; Sánchez, Alvaro I., MD/MS ; Chen, Antonia F., MD/MBA ; Crossett, Lawrence S., MD</creatorcontrib><description>Abstract Survival after solid organ transplants in the United States is increasing, and there is a need to understand the complications in knee arthroplasty patients who underwent organ transplantation. A retrospective study was conducted from 1993–2008 on 19 patients (23 knee arthroplasties) with previous successful solid organ transplants. Eleven knee arthroplasties were performed after renal transplantation, and 12 after nonrenal solid organ transplant (seven liver, four heart, one lung). Complications occurred in 9/23 patients (39.1%) and infections occurred in 4/23 patients (17.3%). Of the infected knees, two had MRSA, one had MSSA, and one Escherichia coli . Noninfectious complications (5/24, 21.7%) include aseptic loosening, quadriceps rupture, femoral fracture, hemarthrosis, and arthrofibrosis. All patients with complications were on immunosuppressant medications at the time of arthroplasty. There was a significantly higher rate of infection in the renal group compared to the non-renal group ( P = 0.022). There was also a higher overall complication rate in the renal group however this did not reach significance.</description><identifier>ISSN: 0883-5403</identifier><identifier>EISSN: 1532-8406</identifier><identifier>DOI: 10.1016/j.arth.2013.02.005</identifier><identifier>PMID: 23558242</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Arthroplasty, Replacement, Knee ; Bacterial Infections - epidemiology ; Bacterial Infections - etiology ; complications ; Female ; Humans ; infections ; Male ; Middle Aged ; Organ Transplantation - adverse effects ; Orthopedics ; Postoperative Complications - epidemiology ; Postoperative Complications - etiology ; Retrospective Studies ; solid organ transplant ; total knee arthroplasty</subject><ispartof>The Journal of arthroplasty, 2013-06, Vol.28 (6), p.960-963</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-fe83c64b5e178fc8b74a6e4cdf8960c721d9bea8d27eda931404afed0fc3e2c33</citedby><cites>FETCH-LOGICAL-c411t-fe83c64b5e178fc8b74a6e4cdf8960c721d9bea8d27eda931404afed0fc3e2c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.arth.2013.02.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23558242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klatt, Brian A., MD</creatorcontrib><creatorcontrib>Steele, G. Daxton, MD</creatorcontrib><creatorcontrib>Fedorka, Catherine J., MD</creatorcontrib><creatorcontrib>Sánchez, Alvaro I., MD/MS</creatorcontrib><creatorcontrib>Chen, Antonia F., MD/MBA</creatorcontrib><creatorcontrib>Crossett, Lawrence S., MD</creatorcontrib><title>Solid Organ Transplant Patients Experience High Rates of Infection and Other Complications After Total Knee Arthroplasty</title><title>The Journal of arthroplasty</title><addtitle>J Arthroplasty</addtitle><description>Abstract Survival after solid organ transplants in the United States is increasing, and there is a need to understand the complications in knee arthroplasty patients who underwent organ transplantation. A retrospective study was conducted from 1993–2008 on 19 patients (23 knee arthroplasties) with previous successful solid organ transplants. Eleven knee arthroplasties were performed after renal transplantation, and 12 after nonrenal solid organ transplant (seven liver, four heart, one lung). Complications occurred in 9/23 patients (39.1%) and infections occurred in 4/23 patients (17.3%). Of the infected knees, two had MRSA, one had MSSA, and one Escherichia coli . Noninfectious complications (5/24, 21.7%) include aseptic loosening, quadriceps rupture, femoral fracture, hemarthrosis, and arthrofibrosis. All patients with complications were on immunosuppressant medications at the time of arthroplasty. There was a significantly higher rate of infection in the renal group compared to the non-renal group ( P = 0.022). There was also a higher overall complication rate in the renal group however this did not reach significance.</description><subject>Aged</subject><subject>Arthroplasty, Replacement, Knee</subject><subject>Bacterial Infections - epidemiology</subject><subject>Bacterial Infections - etiology</subject><subject>complications</subject><subject>Female</subject><subject>Humans</subject><subject>infections</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Organ Transplantation - adverse effects</subject><subject>Orthopedics</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - etiology</subject><subject>Retrospective Studies</subject><subject>solid organ transplant</subject><subject>total knee arthroplasty</subject><issn>0883-5403</issn><issn>1532-8406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1uEzEUhS0EomnhBVggL9nM4L-ZcSSEFEWlrajUqg1ry_FcNw4Te7Ad1Lx9PU1hwYKVratzjn2_g9AHSmpKaPt5W-uYNzUjlNeE1YQ0r9CMNpxVUpD2NZoRKXnVCMJP0GlKW0IobRrxFp0w3jSSCTZDj_dhcD2-iQ_a41XUPo2D9hnf6uzA54TPH0eI5WoAX7qHDb7TGRIOFl95Cya74LH2JSBvIOJl2I2DM3oaJ7ywucxWIesBf_cAeFG-G0N5IOXDO_TG6iHB-5fzDP34dr5aXlbXNxdXy8V1ZQSlubIguWnFugHaSWvkuhO6BWF6K-ctMR2j_XwNWvasg17PORVEaAs9sYYDM5yfoU_H3DGGX3tIWe1cMjCULSHsk6IFhZCUClqk7Cg1MaQUwaoxup2OB0WJmoirrZqIq4m4IkwV4sX08SV_v95B_9fyB3ERfDkKoGz520FUyTzz7F0sAFUf3P_zv_5jN4PzhfHwEw6QtmEffeGnqErFoO6nzqfKKS91t53kT60bqOA</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Klatt, Brian A., MD</creator><creator>Steele, G. Daxton, MD</creator><creator>Fedorka, Catherine J., MD</creator><creator>Sánchez, Alvaro I., MD/MS</creator><creator>Chen, Antonia F., MD/MBA</creator><creator>Crossett, Lawrence S., MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130601</creationdate><title>Solid Organ Transplant Patients Experience High Rates of Infection and Other Complications After Total Knee Arthroplasty</title><author>Klatt, Brian A., MD ; Steele, G. Daxton, MD ; Fedorka, Catherine J., MD ; Sánchez, Alvaro I., MD/MS ; Chen, Antonia F., MD/MBA ; Crossett, Lawrence S., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-fe83c64b5e178fc8b74a6e4cdf8960c721d9bea8d27eda931404afed0fc3e2c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Arthroplasty, Replacement, Knee</topic><topic>Bacterial Infections - epidemiology</topic><topic>Bacterial Infections - etiology</topic><topic>complications</topic><topic>Female</topic><topic>Humans</topic><topic>infections</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Organ Transplantation - adverse effects</topic><topic>Orthopedics</topic><topic>Postoperative Complications - epidemiology</topic><topic>Postoperative Complications - etiology</topic><topic>Retrospective Studies</topic><topic>solid organ transplant</topic><topic>total knee arthroplasty</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klatt, Brian A., MD</creatorcontrib><creatorcontrib>Steele, G. 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Daxton, MD</au><au>Fedorka, Catherine J., MD</au><au>Sánchez, Alvaro I., MD/MS</au><au>Chen, Antonia F., MD/MBA</au><au>Crossett, Lawrence S., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Solid Organ Transplant Patients Experience High Rates of Infection and Other Complications After Total Knee Arthroplasty</atitle><jtitle>The Journal of arthroplasty</jtitle><addtitle>J Arthroplasty</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>28</volume><issue>6</issue><spage>960</spage><epage>963</epage><pages>960-963</pages><issn>0883-5403</issn><eissn>1532-8406</eissn><abstract>Abstract Survival after solid organ transplants in the United States is increasing, and there is a need to understand the complications in knee arthroplasty patients who underwent organ transplantation. A retrospective study was conducted from 1993–2008 on 19 patients (23 knee arthroplasties) with previous successful solid organ transplants. Eleven knee arthroplasties were performed after renal transplantation, and 12 after nonrenal solid organ transplant (seven liver, four heart, one lung). Complications occurred in 9/23 patients (39.1%) and infections occurred in 4/23 patients (17.3%). Of the infected knees, two had MRSA, one had MSSA, and one Escherichia coli . Noninfectious complications (5/24, 21.7%) include aseptic loosening, quadriceps rupture, femoral fracture, hemarthrosis, and arthrofibrosis. All patients with complications were on immunosuppressant medications at the time of arthroplasty. There was a significantly higher rate of infection in the renal group compared to the non-renal group ( P = 0.022). There was also a higher overall complication rate in the renal group however this did not reach significance.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23558242</pmid><doi>10.1016/j.arth.2013.02.005</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Arthroplasty, Replacement, Knee Bacterial Infections - epidemiology Bacterial Infections - etiology complications Female Humans infections Male Middle Aged Organ Transplantation - adverse effects Orthopedics Postoperative Complications - epidemiology Postoperative Complications - etiology Retrospective Studies solid organ transplant total knee arthroplasty |
| title | Solid Organ Transplant Patients Experience High Rates of Infection and Other Complications After Total Knee Arthroplasty |
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