Value of metastin receptor immunohistochemistry in predicting metastasis after radical nephrectomy for pT1 clear cell renal cell carcinoma
KISS - 1 is a metastasis-suppressor gene of human melanoma, and encodes metastin, which was identified as the ligand of a G-protein-coupled receptor (metastin receptor). The precursor protein is cleaved to 54 amino acids, which may be further truncated into carboxy-terminal fragments. Previous studi...
Gespeichert in:
| Veröffentlicht in: | Clinical & experimental metastasis 2013-06, Vol.30 (5), p.607-614 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 614 |
|---|---|
| container_issue | 5 |
| container_start_page | 607 |
| container_title | Clinical & experimental metastasis |
| container_volume | 30 |
| creator | Shoji, Sunao Nakano, Mayura Tomonaga, Tetsuro Kim, Hakushi Hanai, Kazuya Usui, Yukio Nagata, Yoshihiro Miyazawa, Masaki Sato, Haruhiro Tang, Xian Yang Osamura, Yoshiyuki Robert Uchida, Toyoaki Terachi, Toshiro Takeya, Koichi |
| description | KISS
-
1
is a metastasis-suppressor gene of human melanoma, and encodes metastin, which was identified as the ligand of a G-protein-coupled receptor (metastin receptor). The precursor protein is cleaved to 54 amino acids, which may be further truncated into carboxy-terminal fragments. Previous studies showed that lack of metastin receptor in clear cell renal cell carcinoma (RCC) is associated with tumor progression, but the prediction of metastasis in patients with pT1 clear cell RCC after radical nephrectomy is difficult. The objective of this study was to evaluate the usefulness of metastin receptor immunohistochemistry in predicting metastasis after nephrectomy for pT1 clear cell RCC. After verification of the correlation between immunostaining and mRNA expression, we evaluated the clinical value of metastin receptor immunohistochemistry. Fifty-four patients were enrolled in this study; following radical nephrectomy, seven patients were found to have lung metastasis. The sensitivity, specificity, positive predictive value, and negative predictive value with negative immunostaining of metastin receptor were 85.7, 97.6, 46.2, and 97.6 %, respectively. Metastasis-free survival rates were significantly higher in patients with positive staining (97.6 %) than in patients with negative staining (53.8 %) (
P
|
| doi_str_mv | 10.1007/s10585-012-9564-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1355479549</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2978250331</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-b3c2ef07916ceaa3be2f870374b463698ce821bcdfa02726f4a6387ff14e6e7f3</originalsourceid><addsrcrecordid>eNp1kc9qGzEQxkVoaJykD5BLEfSSyzb6L-2xmDYNGHJxchVaeWRv2F1tpd2DXyFPHTl2Syn0NAPz-76Z4UPohpKvlBB9lymRRlaEsqqWSlT8DC2o1LzSTKsPaEGYYhUxtblAlzm_EEKE1uYjumCcaS0YW6DXZ9fNgGPAPUwuT-2AE3gYp5hw2_fzEHdtnqLfQV9q2uMCjAk2rS_o9iRyuc3YhQkSTq6MXIcHGHfFaIr9HofiNa4p9h24hD10XdkxFOi99S75doi9u0bnwXUZPp3qFXr68X29_FmtHu8flt9WlRfcTFXDPYNAdE2VB-d4AywYTbgWjVBc1caDYbTxm-AI00wF4RQ3OgQqQIEO_ArdHn3HFH_NkCdbXjuc4gaIc7aUSyl0LUVd0C__oC9xTuX0d0poIqU6UPRI-RRzThDsmNrepb2lxB6CssegbAnKHoKyvGg-n5znpofNH8XvZArAjkAuo2EL6a_V_3V9A6KEoMM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1354705569</pqid></control><display><type>article</type><title>Value of metastin receptor immunohistochemistry in predicting metastasis after radical nephrectomy for pT1 clear cell renal cell carcinoma</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Shoji, Sunao ; Nakano, Mayura ; Tomonaga, Tetsuro ; Kim, Hakushi ; Hanai, Kazuya ; Usui, Yukio ; Nagata, Yoshihiro ; Miyazawa, Masaki ; Sato, Haruhiro ; Tang, Xian Yang ; Osamura, Yoshiyuki Robert ; Uchida, Toyoaki ; Terachi, Toshiro ; Takeya, Koichi</creator><creatorcontrib>Shoji, Sunao ; Nakano, Mayura ; Tomonaga, Tetsuro ; Kim, Hakushi ; Hanai, Kazuya ; Usui, Yukio ; Nagata, Yoshihiro ; Miyazawa, Masaki ; Sato, Haruhiro ; Tang, Xian Yang ; Osamura, Yoshiyuki Robert ; Uchida, Toyoaki ; Terachi, Toshiro ; Takeya, Koichi</creatorcontrib><description>KISS
-
1
is a metastasis-suppressor gene of human melanoma, and encodes metastin, which was identified as the ligand of a G-protein-coupled receptor (metastin receptor). The precursor protein is cleaved to 54 amino acids, which may be further truncated into carboxy-terminal fragments. Previous studies showed that lack of metastin receptor in clear cell renal cell carcinoma (RCC) is associated with tumor progression, but the prediction of metastasis in patients with pT1 clear cell RCC after radical nephrectomy is difficult. The objective of this study was to evaluate the usefulness of metastin receptor immunohistochemistry in predicting metastasis after nephrectomy for pT1 clear cell RCC. After verification of the correlation between immunostaining and mRNA expression, we evaluated the clinical value of metastin receptor immunohistochemistry. Fifty-four patients were enrolled in this study; following radical nephrectomy, seven patients were found to have lung metastasis. The sensitivity, specificity, positive predictive value, and negative predictive value with negative immunostaining of metastin receptor were 85.7, 97.6, 46.2, and 97.6 %, respectively. Metastasis-free survival rates were significantly higher in patients with positive staining (97.6 %) than in patients with negative staining (53.8 %) (
P
< 0.001). In univariate analysis for metastasis-free survival, negative immunostaining of metastin receptor was a significant risk factor for metastasis (
P
= 0.001). Furthermore, negative immunostaining of metastin receptor was an independent predictor for metastasis in multivariate analysis (hazard ratio, 3.735; 95 % CI 0.629–22.174;
P
= 0.002). In conclusion, our study suggests that negative expression of metastin receptor in clear cell RCC is significantly related to metastasis.</description><identifier>ISSN: 0262-0898</identifier><identifier>EISSN: 1573-7276</identifier><identifier>DOI: 10.1007/s10585-012-9564-3</identifier><identifier>PMID: 23277422</identifier><identifier>CODEN: CEXMD2</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adult ; Aged ; Biomarkers, Tumor - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Carcinoma, Renal Cell - metabolism ; Carcinoma, Renal Cell - pathology ; Carcinoma, Renal Cell - surgery ; Female ; Hematology ; Humans ; Immunohistochemistry ; Kidney Neoplasms - metabolism ; Kidney Neoplasms - pathology ; Kidney Neoplasms - surgery ; Male ; Middle Aged ; Nephrectomy - methods ; Oncology ; Receptors, G-Protein-Coupled - metabolism ; Receptors, Kisspeptin-1 ; Research Paper ; Surgical Oncology</subject><ispartof>Clinical & experimental metastasis, 2013-06, Vol.30 (5), p.607-614</ispartof><rights>Springer Science+Business Media Dordrecht 2012</rights><rights>Springer Science+Business Media Dordrecht 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-b3c2ef07916ceaa3be2f870374b463698ce821bcdfa02726f4a6387ff14e6e7f3</citedby><cites>FETCH-LOGICAL-c438t-b3c2ef07916ceaa3be2f870374b463698ce821bcdfa02726f4a6387ff14e6e7f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10585-012-9564-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10585-012-9564-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23277422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shoji, Sunao</creatorcontrib><creatorcontrib>Nakano, Mayura</creatorcontrib><creatorcontrib>Tomonaga, Tetsuro</creatorcontrib><creatorcontrib>Kim, Hakushi</creatorcontrib><creatorcontrib>Hanai, Kazuya</creatorcontrib><creatorcontrib>Usui, Yukio</creatorcontrib><creatorcontrib>Nagata, Yoshihiro</creatorcontrib><creatorcontrib>Miyazawa, Masaki</creatorcontrib><creatorcontrib>Sato, Haruhiro</creatorcontrib><creatorcontrib>Tang, Xian Yang</creatorcontrib><creatorcontrib>Osamura, Yoshiyuki Robert</creatorcontrib><creatorcontrib>Uchida, Toyoaki</creatorcontrib><creatorcontrib>Terachi, Toshiro</creatorcontrib><creatorcontrib>Takeya, Koichi</creatorcontrib><title>Value of metastin receptor immunohistochemistry in predicting metastasis after radical nephrectomy for pT1 clear cell renal cell carcinoma</title><title>Clinical & experimental metastasis</title><addtitle>Clin Exp Metastasis</addtitle><addtitle>Clin Exp Metastasis</addtitle><description>KISS
-
1
is a metastasis-suppressor gene of human melanoma, and encodes metastin, which was identified as the ligand of a G-protein-coupled receptor (metastin receptor). The precursor protein is cleaved to 54 amino acids, which may be further truncated into carboxy-terminal fragments. Previous studies showed that lack of metastin receptor in clear cell renal cell carcinoma (RCC) is associated with tumor progression, but the prediction of metastasis in patients with pT1 clear cell RCC after radical nephrectomy is difficult. The objective of this study was to evaluate the usefulness of metastin receptor immunohistochemistry in predicting metastasis after nephrectomy for pT1 clear cell RCC. After verification of the correlation between immunostaining and mRNA expression, we evaluated the clinical value of metastin receptor immunohistochemistry. Fifty-four patients were enrolled in this study; following radical nephrectomy, seven patients were found to have lung metastasis. The sensitivity, specificity, positive predictive value, and negative predictive value with negative immunostaining of metastin receptor were 85.7, 97.6, 46.2, and 97.6 %, respectively. Metastasis-free survival rates were significantly higher in patients with positive staining (97.6 %) than in patients with negative staining (53.8 %) (
P
< 0.001). In univariate analysis for metastasis-free survival, negative immunostaining of metastin receptor was a significant risk factor for metastasis (
P
= 0.001). Furthermore, negative immunostaining of metastin receptor was an independent predictor for metastasis in multivariate analysis (hazard ratio, 3.735; 95 % CI 0.629–22.174;
P
= 0.002). In conclusion, our study suggests that negative expression of metastin receptor in clear cell RCC is significantly related to metastasis.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Carcinoma, Renal Cell - metabolism</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>Carcinoma, Renal Cell - surgery</subject><subject>Female</subject><subject>Hematology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Kidney Neoplasms - metabolism</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidney Neoplasms - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nephrectomy - methods</subject><subject>Oncology</subject><subject>Receptors, G-Protein-Coupled - metabolism</subject><subject>Receptors, Kisspeptin-1</subject><subject>Research Paper</subject><subject>Surgical Oncology</subject><issn>0262-0898</issn><issn>1573-7276</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc9qGzEQxkVoaJykD5BLEfSSyzb6L-2xmDYNGHJxchVaeWRv2F1tpd2DXyFPHTl2Syn0NAPz-76Z4UPohpKvlBB9lymRRlaEsqqWSlT8DC2o1LzSTKsPaEGYYhUxtblAlzm_EEKE1uYjumCcaS0YW6DXZ9fNgGPAPUwuT-2AE3gYp5hw2_fzEHdtnqLfQV9q2uMCjAk2rS_o9iRyuc3YhQkSTq6MXIcHGHfFaIr9HofiNa4p9h24hD10XdkxFOi99S75doi9u0bnwXUZPp3qFXr68X29_FmtHu8flt9WlRfcTFXDPYNAdE2VB-d4AywYTbgWjVBc1caDYbTxm-AI00wF4RQ3OgQqQIEO_ArdHn3HFH_NkCdbXjuc4gaIc7aUSyl0LUVd0C__oC9xTuX0d0poIqU6UPRI-RRzThDsmNrepb2lxB6CssegbAnKHoKyvGg-n5znpofNH8XvZArAjkAuo2EL6a_V_3V9A6KEoMM</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Shoji, Sunao</creator><creator>Nakano, Mayura</creator><creator>Tomonaga, Tetsuro</creator><creator>Kim, Hakushi</creator><creator>Hanai, Kazuya</creator><creator>Usui, Yukio</creator><creator>Nagata, Yoshihiro</creator><creator>Miyazawa, Masaki</creator><creator>Sato, Haruhiro</creator><creator>Tang, Xian Yang</creator><creator>Osamura, Yoshiyuki Robert</creator><creator>Uchida, Toyoaki</creator><creator>Terachi, Toshiro</creator><creator>Takeya, Koichi</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20130601</creationdate><title>Value of metastin receptor immunohistochemistry in predicting metastasis after radical nephrectomy for pT1 clear cell renal cell carcinoma</title><author>Shoji, Sunao ; Nakano, Mayura ; Tomonaga, Tetsuro ; Kim, Hakushi ; Hanai, Kazuya ; Usui, Yukio ; Nagata, Yoshihiro ; Miyazawa, Masaki ; Sato, Haruhiro ; Tang, Xian Yang ; Osamura, Yoshiyuki Robert ; Uchida, Toyoaki ; Terachi, Toshiro ; Takeya, Koichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-b3c2ef07916ceaa3be2f870374b463698ce821bcdfa02726f4a6387ff14e6e7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Carcinoma, Renal Cell - metabolism</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>Carcinoma, Renal Cell - surgery</topic><topic>Female</topic><topic>Hematology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Kidney Neoplasms - metabolism</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidney Neoplasms - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nephrectomy - methods</topic><topic>Oncology</topic><topic>Receptors, G-Protein-Coupled - metabolism</topic><topic>Receptors, Kisspeptin-1</topic><topic>Research Paper</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shoji, Sunao</creatorcontrib><creatorcontrib>Nakano, Mayura</creatorcontrib><creatorcontrib>Tomonaga, Tetsuro</creatorcontrib><creatorcontrib>Kim, Hakushi</creatorcontrib><creatorcontrib>Hanai, Kazuya</creatorcontrib><creatorcontrib>Usui, Yukio</creatorcontrib><creatorcontrib>Nagata, Yoshihiro</creatorcontrib><creatorcontrib>Miyazawa, Masaki</creatorcontrib><creatorcontrib>Sato, Haruhiro</creatorcontrib><creatorcontrib>Tang, Xian Yang</creatorcontrib><creatorcontrib>Osamura, Yoshiyuki Robert</creatorcontrib><creatorcontrib>Uchida, Toyoaki</creatorcontrib><creatorcontrib>Terachi, Toshiro</creatorcontrib><creatorcontrib>Takeya, Koichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical & experimental metastasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shoji, Sunao</au><au>Nakano, Mayura</au><au>Tomonaga, Tetsuro</au><au>Kim, Hakushi</au><au>Hanai, Kazuya</au><au>Usui, Yukio</au><au>Nagata, Yoshihiro</au><au>Miyazawa, Masaki</au><au>Sato, Haruhiro</au><au>Tang, Xian Yang</au><au>Osamura, Yoshiyuki Robert</au><au>Uchida, Toyoaki</au><au>Terachi, Toshiro</au><au>Takeya, Koichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Value of metastin receptor immunohistochemistry in predicting metastasis after radical nephrectomy for pT1 clear cell renal cell carcinoma</atitle><jtitle>Clinical & experimental metastasis</jtitle><stitle>Clin Exp Metastasis</stitle><addtitle>Clin Exp Metastasis</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>30</volume><issue>5</issue><spage>607</spage><epage>614</epage><pages>607-614</pages><issn>0262-0898</issn><eissn>1573-7276</eissn><coden>CEXMD2</coden><abstract>KISS
-
1
is a metastasis-suppressor gene of human melanoma, and encodes metastin, which was identified as the ligand of a G-protein-coupled receptor (metastin receptor). The precursor protein is cleaved to 54 amino acids, which may be further truncated into carboxy-terminal fragments. Previous studies showed that lack of metastin receptor in clear cell renal cell carcinoma (RCC) is associated with tumor progression, but the prediction of metastasis in patients with pT1 clear cell RCC after radical nephrectomy is difficult. The objective of this study was to evaluate the usefulness of metastin receptor immunohistochemistry in predicting metastasis after nephrectomy for pT1 clear cell RCC. After verification of the correlation between immunostaining and mRNA expression, we evaluated the clinical value of metastin receptor immunohistochemistry. Fifty-four patients were enrolled in this study; following radical nephrectomy, seven patients were found to have lung metastasis. The sensitivity, specificity, positive predictive value, and negative predictive value with negative immunostaining of metastin receptor were 85.7, 97.6, 46.2, and 97.6 %, respectively. Metastasis-free survival rates were significantly higher in patients with positive staining (97.6 %) than in patients with negative staining (53.8 %) (
P
< 0.001). In univariate analysis for metastasis-free survival, negative immunostaining of metastin receptor was a significant risk factor for metastasis (
P
= 0.001). Furthermore, negative immunostaining of metastin receptor was an independent predictor for metastasis in multivariate analysis (hazard ratio, 3.735; 95 % CI 0.629–22.174;
P
= 0.002). In conclusion, our study suggests that negative expression of metastin receptor in clear cell RCC is significantly related to metastasis.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>23277422</pmid><doi>10.1007/s10585-012-9564-3</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0262-0898 |
| ispartof | Clinical & experimental metastasis, 2013-06, Vol.30 (5), p.607-614 |
| issn | 0262-0898 1573-7276 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1355479549 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Aged Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Carcinoma, Renal Cell - surgery Female Hematology Humans Immunohistochemistry Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Kidney Neoplasms - surgery Male Middle Aged Nephrectomy - methods Oncology Receptors, G-Protein-Coupled - metabolism Receptors, Kisspeptin-1 Research Paper Surgical Oncology |
| title | Value of metastin receptor immunohistochemistry in predicting metastasis after radical nephrectomy for pT1 clear cell renal cell carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T15%3A50%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Value%20of%20metastin%20receptor%20immunohistochemistry%20in%20predicting%20metastasis%20after%20radical%20nephrectomy%20for%20pT1%20clear%20cell%20renal%20cell%20carcinoma&rft.jtitle=Clinical%20&%20experimental%20metastasis&rft.au=Shoji,%20Sunao&rft.date=2013-06-01&rft.volume=30&rft.issue=5&rft.spage=607&rft.epage=614&rft.pages=607-614&rft.issn=0262-0898&rft.eissn=1573-7276&rft.coden=CEXMD2&rft_id=info:doi/10.1007/s10585-012-9564-3&rft_dat=%3Cproquest_cross%3E2978250331%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1354705569&rft_id=info:pmid/23277422&rfr_iscdi=true |