Versatile Approaches for the Synthesis of Fused-Ring γ‑Lactones Utilizing Cyclopropane Intermediates
A highly effective acid-catalyzed cyclopropyl ester to γ-lactone skeletal rearrangement has been demonstrated and applied to the synthesis of a variety of bi- and tricyclic functionalized lactones, rigid and highly compact structures for use as biological probes.
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| Veröffentlicht in: | Organic letters 2013-04, Vol.15 (7), p.1591-1593 |
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| container_end_page | 1593 |
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| container_issue | 7 |
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| container_title | Organic letters |
| container_volume | 15 |
| creator | Newhouse, Timothy R Kaib, Philip S. J Gross, Andrew W Corey, E. J |
| description | A highly effective acid-catalyzed cyclopropyl ester to γ-lactone skeletal rearrangement has been demonstrated and applied to the synthesis of a variety of bi- and tricyclic functionalized lactones, rigid and highly compact structures for use as biological probes. |
| doi_str_mv | 10.1021/ol400362t |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1523-7060 |
| ispartof | Organic letters, 2013-04, Vol.15 (7), p.1591-1593 |
| issn | 1523-7060 1523-7052 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Catalysis Crystallography, X-Ray Cyclopropanes - chemistry Esters Lactones - chemical synthesis Lactones - chemistry Molecular Conformation Molecular Structure Stereoisomerism |
| title | Versatile Approaches for the Synthesis of Fused-Ring γ‑Lactones Utilizing Cyclopropane Intermediates |
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