A therapeutic strategy for metastatic malignant fibrous histiocytoma through mesenchymal stromal cell-mediated TRAIL production

To overcome the therapeutic limitations of malignant fibrous histiocytoma (MFH), we evaluated human adipose tissue-derived mesenchymal stromal cells (MSCs) that secrete tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on metastatic MFH. MFH is a highly malignant and metastatic type of...

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Veröffentlicht in:	Annals of surgery 2013-05, Vol.257 (5), p.952-960
Hauptverfasser:	Lee, Hyun Joo, Yang, Heung-Mo, Choi, Young-Sil, Park, Sang-Hoon, Moon, Sung-Hwan, Lee, Yong-Soo, Sung, Young Chul, Kim, Sung Joo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue, White - cytology Animals Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis - drug effects Flow Cytometry Genetic Therapy - methods Histiocytoma, Malignant Fibrous - pathology Histiocytoma, Malignant Fibrous - therapy Humans Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - metabolism Mice Mice, Inbred NOD Neoplasm Metastasis TNF-Related Apoptosis-Inducing Ligand - genetics TNF-Related Apoptosis-Inducing Ligand - metabolism TNF-Related Apoptosis-Inducing Ligand - pharmacology TNF-Related Apoptosis-Inducing Ligand - therapeutic use Transduction, Genetic Transgenes Tumor Cells, Cultured
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