Does lofepramine have fewer side effects than amitriptyline?: Results of a comparative trial
A double blind trial was carried out comparing the tricyclic antidepressant lofepramine with amitriptyline in the treatment of patients suffering from moderate to markedly severe depression. No difference was demonstrated between the two drugs in terms of their antidepressant effect, but patients tr...
Gespeichert in:
| Veröffentlicht in: | Journal of affective disorders 1982-01, Vol.4 (4), p.355-363 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 363 |
|---|---|
| container_issue | 4 |
| container_start_page | 355 |
| container_title | Journal of affective disorders |
| container_volume | 4 |
| creator | Pugh, R. Bell, Janne Cooper, A.J. Dunstan, S. Greedharry, D. Pomeroy, J. Raptopoulos, P. Rowsell, Charmian Steinert, J. Priest, R.G. |
| description | A double blind trial was carried out comparing the tricyclic antidepressant lofepramine with amitriptyline in the treatment of patients suffering from moderate to markedly severe depression.
No difference was demonstrated between the two drugs in terms of their antidepressant effect, but patients treated with lofepramine suffered from singificantly less side effects than patients treated with amitriptyline. Both groups of patients had a high drop out rate but this was less marked in the groups of patients treated with lofepramine. |
| doi_str_mv | 10.1016/0165-0327(82)90031-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_13552546</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0165032782900313</els_id><sourcerecordid>13552546</sourcerecordid><originalsourceid>FETCH-LOGICAL-e292t-3c0a31456ae60c8793a0724f39cdf7e9340e72d60351ac5f850d7fccabfc42e93</originalsourceid><addsrcrecordid>eNo9kE1LAzEQQIMotVb_gUJOoofVfGw2Gw-K1E8oCKI3IaTZCY3sdtdkt9J_b6rFwzCH9xiGh9AxJReU0OIyjcgIZ_KsZOeKEE4zvoPGVEieMUHlLhr_K_voIMZPQkihJBmhUcGoorkao4-7FiKuWwddMI1fAl6YFWAH3xBw9BVgcA5sH3G_MEuclD74rl_XSb25wq8QhzrB1mGDbdt0JpjepwPJMvUh2nOmjnC03RP0_nD_Nn3KZi-Pz9PbWQZMsT7jlhhOc1EYKIgtpeKGSJY7rmzlJCieE5CsKggX1FjhSkEq6aw1c2dzlvgEnf7d7UL7NUDsdeOjhbo2S2iHqCkXgom8SOLJVhzmDVS6C74xYa23ORK__uOQvl15CDpaD0sLlQ8pgq5arynRm_x601Zv2uqS6d_8mvMfblx2xQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>13552546</pqid></control><display><type>article</type><title>Does lofepramine have fewer side effects than amitriptyline?: Results of a comparative trial</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Pugh, R. ; Bell, Janne ; Cooper, A.J. ; Dunstan, S. ; Greedharry, D. ; Pomeroy, J. ; Raptopoulos, P. ; Rowsell, Charmian ; Steinert, J. ; Priest, R.G.</creator><creatorcontrib>Pugh, R. ; Bell, Janne ; Cooper, A.J. ; Dunstan, S. ; Greedharry, D. ; Pomeroy, J. ; Raptopoulos, P. ; Rowsell, Charmian ; Steinert, J. ; Priest, R.G.</creatorcontrib><description>A double blind trial was carried out comparing the tricyclic antidepressant lofepramine with amitriptyline in the treatment of patients suffering from moderate to markedly severe depression.
No difference was demonstrated between the two drugs in terms of their antidepressant effect, but patients treated with lofepramine suffered from singificantly less side effects than patients treated with amitriptyline. Both groups of patients had a high drop out rate but this was less marked in the groups of patients treated with lofepramine.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/0165-0327(82)90031-3</identifier><identifier>PMID: 6219149</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Aged ; Amitriptyline - adverse effects ; Amitriptyline - therapeutic use ; Clinical Trials as Topic ; Depressive Disorder - drug therapy ; Depressive Disorder - psychology ; Dibenzazepines - adverse effects ; Double-Blind Method ; Female ; Humans ; Lofepramine - adverse effects ; Lofepramine - therapeutic use ; Male ; Middle Aged ; Psychiatric Status Rating Scales</subject><ispartof>Journal of affective disorders, 1982-01, Vol.4 (4), p.355-363</ispartof><rights>1982</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0165-0327(82)90031-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6219149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pugh, R.</creatorcontrib><creatorcontrib>Bell, Janne</creatorcontrib><creatorcontrib>Cooper, A.J.</creatorcontrib><creatorcontrib>Dunstan, S.</creatorcontrib><creatorcontrib>Greedharry, D.</creatorcontrib><creatorcontrib>Pomeroy, J.</creatorcontrib><creatorcontrib>Raptopoulos, P.</creatorcontrib><creatorcontrib>Rowsell, Charmian</creatorcontrib><creatorcontrib>Steinert, J.</creatorcontrib><creatorcontrib>Priest, R.G.</creatorcontrib><title>Does lofepramine have fewer side effects than amitriptyline?: Results of a comparative trial</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>A double blind trial was carried out comparing the tricyclic antidepressant lofepramine with amitriptyline in the treatment of patients suffering from moderate to markedly severe depression.
No difference was demonstrated between the two drugs in terms of their antidepressant effect, but patients treated with lofepramine suffered from singificantly less side effects than patients treated with amitriptyline. Both groups of patients had a high drop out rate but this was less marked in the groups of patients treated with lofepramine.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Amitriptyline - adverse effects</subject><subject>Amitriptyline - therapeutic use</subject><subject>Clinical Trials as Topic</subject><subject>Depressive Disorder - drug therapy</subject><subject>Depressive Disorder - psychology</subject><subject>Dibenzazepines - adverse effects</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Lofepramine - adverse effects</subject><subject>Lofepramine - therapeutic use</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Psychiatric Status Rating Scales</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LAzEQQIMotVb_gUJOoofVfGw2Gw-K1E8oCKI3IaTZCY3sdtdkt9J_b6rFwzCH9xiGh9AxJReU0OIyjcgIZ_KsZOeKEE4zvoPGVEieMUHlLhr_K_voIMZPQkihJBmhUcGoorkao4-7FiKuWwddMI1fAl6YFWAH3xBw9BVgcA5sH3G_MEuclD74rl_XSb25wq8QhzrB1mGDbdt0JpjepwPJMvUh2nOmjnC03RP0_nD_Nn3KZi-Pz9PbWQZMsT7jlhhOc1EYKIgtpeKGSJY7rmzlJCieE5CsKggX1FjhSkEq6aw1c2dzlvgEnf7d7UL7NUDsdeOjhbo2S2iHqCkXgom8SOLJVhzmDVS6C74xYa23ORK__uOQvl15CDpaD0sLlQ8pgq5arynRm_x601Zv2uqS6d_8mvMfblx2xQ</recordid><startdate>19820101</startdate><enddate>19820101</enddate><creator>Pugh, R.</creator><creator>Bell, Janne</creator><creator>Cooper, A.J.</creator><creator>Dunstan, S.</creator><creator>Greedharry, D.</creator><creator>Pomeroy, J.</creator><creator>Raptopoulos, P.</creator><creator>Rowsell, Charmian</creator><creator>Steinert, J.</creator><creator>Priest, R.G.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19820101</creationdate><title>Does lofepramine have fewer side effects than amitriptyline?: Results of a comparative trial</title><author>Pugh, R. ; Bell, Janne ; Cooper, A.J. ; Dunstan, S. ; Greedharry, D. ; Pomeroy, J. ; Raptopoulos, P. ; Rowsell, Charmian ; Steinert, J. ; Priest, R.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e292t-3c0a31456ae60c8793a0724f39cdf7e9340e72d60351ac5f850d7fccabfc42e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Amitriptyline - adverse effects</topic><topic>Amitriptyline - therapeutic use</topic><topic>Clinical Trials as Topic</topic><topic>Depressive Disorder - drug therapy</topic><topic>Depressive Disorder - psychology</topic><topic>Dibenzazepines - adverse effects</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Lofepramine - adverse effects</topic><topic>Lofepramine - therapeutic use</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Psychiatric Status Rating Scales</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pugh, R.</creatorcontrib><creatorcontrib>Bell, Janne</creatorcontrib><creatorcontrib>Cooper, A.J.</creatorcontrib><creatorcontrib>Dunstan, S.</creatorcontrib><creatorcontrib>Greedharry, D.</creatorcontrib><creatorcontrib>Pomeroy, J.</creatorcontrib><creatorcontrib>Raptopoulos, P.</creatorcontrib><creatorcontrib>Rowsell, Charmian</creatorcontrib><creatorcontrib>Steinert, J.</creatorcontrib><creatorcontrib>Priest, R.G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pugh, R.</au><au>Bell, Janne</au><au>Cooper, A.J.</au><au>Dunstan, S.</au><au>Greedharry, D.</au><au>Pomeroy, J.</au><au>Raptopoulos, P.</au><au>Rowsell, Charmian</au><au>Steinert, J.</au><au>Priest, R.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does lofepramine have fewer side effects than amitriptyline?: Results of a comparative trial</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>1982-01-01</date><risdate>1982</risdate><volume>4</volume><issue>4</issue><spage>355</spage><epage>363</epage><pages>355-363</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><abstract>A double blind trial was carried out comparing the tricyclic antidepressant lofepramine with amitriptyline in the treatment of patients suffering from moderate to markedly severe depression.
No difference was demonstrated between the two drugs in terms of their antidepressant effect, but patients treated with lofepramine suffered from singificantly less side effects than patients treated with amitriptyline. Both groups of patients had a high drop out rate but this was less marked in the groups of patients treated with lofepramine.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>6219149</pmid><doi>10.1016/0165-0327(82)90031-3</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-0327 |
| ispartof | Journal of affective disorders, 1982-01, Vol.4 (4), p.355-363 |
| issn | 0165-0327 1573-2517 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_13552546 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Aged Amitriptyline - adverse effects Amitriptyline - therapeutic use Clinical Trials as Topic Depressive Disorder - drug therapy Depressive Disorder - psychology Dibenzazepines - adverse effects Double-Blind Method Female Humans Lofepramine - adverse effects Lofepramine - therapeutic use Male Middle Aged Psychiatric Status Rating Scales |
| title | Does lofepramine have fewer side effects than amitriptyline?: Results of a comparative trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T06%3A58%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Does%20lofepramine%20have%20fewer%20side%20effects%20than%20amitriptyline?:%20Results%20of%20a%20comparative%20trial&rft.jtitle=Journal%20of%20affective%20disorders&rft.au=Pugh,%20R.&rft.date=1982-01-01&rft.volume=4&rft.issue=4&rft.spage=355&rft.epage=363&rft.pages=355-363&rft.issn=0165-0327&rft.eissn=1573-2517&rft_id=info:doi/10.1016/0165-0327(82)90031-3&rft_dat=%3Cproquest_pubme%3E13552546%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=13552546&rft_id=info:pmid/6219149&rft_els_id=0165032782900313&rfr_iscdi=true |