The role of lysosomes in the pathogenesis of copper-induced hepatotoxicity
The effects of altered lysosomal function on the pathogenesis of copper-induced hepatotoxicity were studied in C57B1/6 bg/bg (beige) and C57B1/6 bg/+ (conventional) mice. Copper loading was accomplished through daily ip injections of aqueous copper chloride at a dosage rate of 8 mg/kg body weight fo...
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| Veröffentlicht in: | Toxicology and applied pharmacology 1983-02, Vol.67 (2), p.238-245 |
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| container_title | Toxicology and applied pharmacology |
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| creator | Helman, R.G. Adams, L.G. Pierce, K.R. Bridges, C.H. Bailey, E.M. |
| description | The effects of altered lysosomal function on the pathogenesis of copper-induced hepatotoxicity were studied in C57B1/6 bg/bg (beige) and C57B1/6 bg/+ (conventional) mice. Copper loading was accomplished through daily ip injections of aqueous copper chloride at a dosage rate of 8 mg/kg body weight for 1, 2, and 4 weeks. The subcellular distribution of copper in copper-treated beige mice was significantly different than that in conventional mice. Levels of total hepatic copper were similar in both groups of mice receiving parenteral copper except at Day 14, when beige mice had higher levels. |
| doi_str_mv | 10.1016/0041-008X(83)90230-2 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0041-008X |
| ispartof | Toxicology and applied pharmacology, 1983-02, Vol.67 (2), p.238-245 |
| issn | 0041-008X |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| title | The role of lysosomes in the pathogenesis of copper-induced hepatotoxicity |
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