Paradoxical Role of 3-Methyladenine in Pyocyanin-Induced Toxicity in 1321N1 Astrocytoma and SH-SY5Y Neuroblastoma Cells

The role of autophagy in pyocyanin (PCN)-induced toxicity in the central nervous system (CNS) remains unclear, with only evidence from our group identifying it as a mechanism underlying toxicity in 1321N1 astrocytoma cells. Therefore, the aim of this study was to further examine the role of autophag...

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Veröffentlicht in:	International journal of toxicology 2013-05, Vol.32 (3), p.209-218
Hauptverfasser:	McFarland, Amelia J., Grant, Gary D., Perkins, Anthony V., Flegg, Cameron, Davey, Andrew K., Allsopp, Tristan J., Renshaw, Gillian, Kavanagh, Justin, McDermott, Catherine M., Anoopkumar-Dukie, Shailendra
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - administration & dosage Adenine - analogs & derivatives Adenine - pharmacology Astrocytoma - metabolism Autophagy - physiology Caspase 3 - genetics Caspase 3 - metabolism Cell Line, Tumor Dinoprostone - genetics Dinoprostone - metabolism Drug Therapy, Combination Gene Expression Regulation - drug effects Humans Interleukin-8 - genetics Interleukin-8 - metabolism Leukotriene B4 - genetics Leukotriene B4 - metabolism Neuroblastoma - metabolism Pyocyanine - toxicity Staining and Labeling
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