Intrahepatic myeloid-cell aggregates enable local proliferation of CD8+ T cells and successful immunotherapy against chronic viral liver infection

Chronic infections are commonly established in the liver. Knolle and colleagues show that cytotoxic T lymphocyte responses can be boosted by TLR-mediated induction of myeloid aggregates (iMATES). Chronic infection is difficult to overcome because of exhaustion or depletion of cytotoxic effector CD8...

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Veröffentlicht in:	Nature immunology 2013-06, Vol.14 (6), p.574-583
Hauptverfasser:	Huang, Li-Rung, Wohlleber, Dirk, Reisinger, Florian, Jenne, Craig N, Cheng, Ru-Lin, Abdullah, Zeinab, Schildberg, Frank A, Odenthal, Margarete, Dienes, Hans-Peter, van Rooijen, Nico, Schmitt, Edgar, Garbi, Natalio, Croft, Michael, Kurts, Christian, Kubes, Paul, Protzer, Ulrike, Heikenwalder, Mathias, Knolle, Percy A
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2152/1566/1618 Aggregates Animals Animals, Newborn Biomedicine CD11b Antigen - immunology CD11b Antigen - metabolism CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Proliferation Chronic Disease Deoxyribonucleic acid DNA Flow Cytometry Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Host-Pathogen Interactions - immunology Immunology Immunotherapy Infectious Diseases Liver Liver - immunology Liver - metabolism Liver - virology Liver Diseases - immunology Liver Diseases - therapy Liver Diseases - virology Lymphocytic Choriomeningitis - immunology Lymphocytic Choriomeningitis - therapy Lymphocytic Choriomeningitis - virology Lymphocytic choriomeningitis virus - immunology Lymphocytic choriomeningitis virus - physiology Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Microscopy, Confocal Myeloid Cells - immunology Myeloid Cells - metabolism Population growth Receptors, OX40 - immunology Receptors, OX40 - metabolism Signal Transduction - immunology T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism Toll-Like Receptor 9 - immunology Toll-Like Receptor 9 - metabolism
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