Characterization of a novel high-potency positive modulator of K(v)7 channels

K(v)7 channel activators decrease neuronal excitability and might potentially treat neuronal hyperexcitability disorders like epilepsy and mania. Here we introduce NS15370 ((2-(3,5-difluorophenyl)-N-[6-[(4-fluorophenyl)methylamino]-2-morpholino-3-pyridyl]acetamide)hydrochloride, an in vitro high-pot...

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Veröffentlicht in:	European journal of pharmacology 2013-06, Vol.709 (1-3), p.52-63
Hauptverfasser:	Dalby-Brown, William, Jessen, Carsten, Hougaard, Charlotte, Jensen, Marianne L, Jacobsen, Thomas A, Nielsen, Karin S, Erichsen, Helle K, Grunnet, Morten, Ahring, Philip K, Christophersen, Palle, Strøbæk, Dorte, Jørgensen, Susanne
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopyridines - pharmacology Aminopyridines - therapeutic use Animals Anticonvulsants - pharmacology Anticonvulsants - therapeutic use Antimanic Agents - pharmacology Antimanic Agents - therapeutic use Antipsychotic Agents - pharmacology Antipsychotic Agents - therapeutic use Benzeneacetamides - pharmacology Benzeneacetamides - therapeutic use Bipolar Disorder - drug therapy Bipolar Disorder - metabolism CA1 Region, Hippocampal - drug effects CA1 Region, Hippocampal - metabolism Disease Models, Animal Dopaminergic Neurons - drug effects Dopaminergic Neurons - metabolism Epilepsies, Partial - drug therapy Epilepsies, Partial - metabolism Female GABAergic Neurons - drug effects GABAergic Neurons - metabolism HEK293 Cells Humans In Vitro Techniques KCNQ1 Potassium Channel - agonists KCNQ1 Potassium Channel - genetics KCNQ1 Potassium Channel - metabolism Male Membrane Transport Modulators - pharmacology Membrane Transport Modulators - therapeutic use Mice Nerve Tissue Proteins - agonists Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Psychotic Disorders - drug therapy Psychotic Disorders - metabolism Rats Recombinant Proteins - metabolism Substantia Nigra - drug effects Substantia Nigra - metabolism
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