Jagged1 is the major regulator of notch‐dependent cell fate in proximal airways

ABSTRACT Background: The Notch signaling pathway plays complex roles in developing lungs, including regulation of proximodistal fates, airway cell specification and differentiation. However, the specific Notch‐mediated signals involved in lung development remain unclear. Results: Here we report that...

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Veröffentlicht in:	Developmental dynamics 2013-06, Vol.242 (6), p.678-686
Hauptverfasser:	Zhang, Shubing, Loch, Amanda J., Radtke, Freddy, Egan, Sean E., Xu, Keli
Format:	Artikel
Sprache:	eng
Schlagworte:	airway cell fate Animals Calcium-Binding Proteins - genetics Calcium-Binding Proteins - physiology Cell Differentiation Cell Lineage Epithelial Cells - metabolism Gene Expression Regulation, Developmental Immunohistochemistry Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - physiology Jagged-1 Protein Jagged1 lung Lung - embryology Lung - metabolism Membrane Proteins - genetics Membrane Proteins - physiology Mice Mice, Transgenic mucous metaplasia Neuroendocrine Cells - metabolism Notch Phenotype Receptors, Notch - metabolism Serrate-Jagged Proteins Signal Transduction Time Factors
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