Anti-nociceptive and anti-allodynic activity of aliskiren in various pain models

In the present study, we have investigated the anti-nociceptive and anti-allodynic activity of the renin inhibitor, aliskiren, in various pain models. The anti-nociceptive activity of aliskiren was investigated in chemically-induced pain, orofacial pain and centrally mediated pain models. Anti-allod...

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Veröffentlicht in:	European journal of pharmacology 2013-05, Vol.708 (1-3), p.80-87
Hauptverfasser:	Patel, Rakesh B., Pawar, Vishwanath D., Prajapati, Kanaiyalal D., Sonara, Bhavin M., Deshpande, Shrikalp S., Shah, Gaurang B., Jain, Mukul R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic Acid Aliskiren Amides - therapeutic use analgesic effect Analgesics - therapeutic use Animals Behavior, Animal Capsaicin Female Formaldehyde Formalin Fumarates - therapeutic use Hot plate test Hot Temperature Hyperalgesia - chemically induced Hyperalgesia - drug therapy Hyperalgesia - physiopathology inflammation interleukin-6 intraperitoneal injection Male Mice Mice, Inbred ICR Motor Activity - drug effects Neuropathic pain pain Pain - drug therapy Pain - etiology Pain - physiopathology Post-operative pain Rats Rats, Sprague-Dawley renin Renin inhibitor tumor necrosis factor-alpha
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