Tandem repeats modify the structure of the canine CD1D gene
Summary Among the CD1 proteins that present lipid antigens to T cells, CD1d is the only one that stimulates a population of T cells with an invariant T‐cell receptor known as NKT cells. Sequencing of a 722 nucleotide gap in the dog (Canis lupus familiaris) genome revealed that the canine CD1D gene l...
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| Veröffentlicht in: | Animal genetics 2013-06, Vol.44 (3), p.352-355 |
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| container_issue | 3 |
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| container_title | Animal genetics |
| container_volume | 44 |
| creator | Looringh van Beeck, F. A. Leegwater, P. A. J. Herrmann, T. Broere, F. Rutten, V. P. M. G. Willemse, T. Van Rhijn, I. |
| description | Summary
Among the CD1 proteins that present lipid antigens to T cells, CD1d is the only one that stimulates a population of T cells with an invariant T‐cell receptor known as NKT cells. Sequencing of a 722 nucleotide gap in the dog (Canis lupus familiaris) genome revealed that the canine CD1D gene lacks a sequence homologous to exon 2 of human CD1D, coding for the start codon and signal peptide. Also, the canine CD1D gene contains three different short tandem repeats that disrupt the expected gene structure. Because canine CD1D cDNA lacks sequences homologous to human exon 2 and 3, the functionality of canine CD1d protein may be affected, and this could have consequences for the development and activation of canine NKT cells. |
| doi_str_mv | 10.1111/age.12002 |
| format | Article |
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Among the CD1 proteins that present lipid antigens to T cells, CD1d is the only one that stimulates a population of T cells with an invariant T‐cell receptor known as NKT cells. Sequencing of a 722 nucleotide gap in the dog (Canis lupus familiaris) genome revealed that the canine CD1D gene lacks a sequence homologous to exon 2 of human CD1D, coding for the start codon and signal peptide. Also, the canine CD1D gene contains three different short tandem repeats that disrupt the expected gene structure. Because canine CD1D cDNA lacks sequences homologous to human exon 2 and 3, the functionality of canine CD1d protein may be affected, and this could have consequences for the development and activation of canine NKT cells.</description><identifier>ISSN: 0268-9146</identifier><identifier>EISSN: 1365-2052</identifier><identifier>DOI: 10.1111/age.12002</identifier><identifier>PMID: 22988997</identifier><identifier>CODEN: ANGEE3</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Animals ; Antigens ; Antigens, CD1d - genetics ; Canis lupus ; CD1 ; DNA, Complementary - genetics ; dog ; Dogs - genetics ; Exons ; Genome ; microsatellite ; Natural Killer T-Cells - metabolism ; NKT cells ; Sequence Analysis, DNA ; Sequence Homology ; simple sequence repeat ; T cell receptors ; Tandem Repeat Sequences ; Transcription, Genetic</subject><ispartof>Animal genetics, 2013-06, Vol.44 (3), p.352-355</ispartof><rights>2012 The Authors, Animal Genetics © 2012 Stichting International Foundation for Animal Genetics</rights><rights>2012 The Authors, Animal Genetics © 2012 Stichting International Foundation for Animal Genetics.</rights><rights>Animal Genetics © 2013 Stichting International Foundation for Animal Genetics</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fage.12002$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fage.12002$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22988997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Looringh van Beeck, F. A.</creatorcontrib><creatorcontrib>Leegwater, P. A. J.</creatorcontrib><creatorcontrib>Herrmann, T.</creatorcontrib><creatorcontrib>Broere, F.</creatorcontrib><creatorcontrib>Rutten, V. P. M. G.</creatorcontrib><creatorcontrib>Willemse, T.</creatorcontrib><creatorcontrib>Van Rhijn, I.</creatorcontrib><title>Tandem repeats modify the structure of the canine CD1D gene</title><title>Animal genetics</title><addtitle>Anim Genet</addtitle><description>Summary
Among the CD1 proteins that present lipid antigens to T cells, CD1d is the only one that stimulates a population of T cells with an invariant T‐cell receptor known as NKT cells. Sequencing of a 722 nucleotide gap in the dog (Canis lupus familiaris) genome revealed that the canine CD1D gene lacks a sequence homologous to exon 2 of human CD1D, coding for the start codon and signal peptide. Also, the canine CD1D gene contains three different short tandem repeats that disrupt the expected gene structure. Because canine CD1D cDNA lacks sequences homologous to human exon 2 and 3, the functionality of canine CD1d protein may be affected, and this could have consequences for the development and activation of canine NKT cells.</description><subject>Animals</subject><subject>Antigens</subject><subject>Antigens, CD1d - genetics</subject><subject>Canis lupus</subject><subject>CD1</subject><subject>DNA, Complementary - genetics</subject><subject>dog</subject><subject>Dogs - genetics</subject><subject>Exons</subject><subject>Genome</subject><subject>microsatellite</subject><subject>Natural Killer T-Cells - metabolism</subject><subject>NKT cells</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology</subject><subject>simple sequence repeat</subject><subject>T cell receptors</subject><subject>Tandem Repeat Sequences</subject><subject>Transcription, Genetic</subject><issn>0268-9146</issn><issn>1365-2052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkclOw0AMhkcIBKVw4AVQJC5c0s4SzyJO0A0kBBJiOY4miQOBJimZRNC3J7SFAyd8sWV_vyX7J-SI0QHrYuieccA4pXyL9JiQEHIKfJv0KJc6NCySe2Tf-1dKqWaK7ZI9zo3WxqgeObt3ZYpFUOMCXeODokrzbBk0Lxj4pm6Tpq0xqLJVI3FlXmIwGrNx8IwlHpCdzM09Hm5ynzxMJ_ejy_D6dnY1Or8OcwGUhxo0VYmImIoTkKBjgw6iFIBHSQJKR2nKsjQ2DGkUmzgzyFFTQYVUXLJIiz45Xe9d1NV7i76xRe4TnM9diVXrLRPQHQSSy3-gQgttBIUOPfmDvlZtXXaHWAZcAxdUq4463lBtXGBqF3VeuHppfz7YAcM18JHPcfk7Z9R-W2M7a-zKGns-m6yKThGuFblv8PNX4eo3K5VQYJ9uZhaiR3V3MeX2SXwBQS2K5w</recordid><startdate>201306</startdate><enddate>201306</enddate><creator>Looringh van Beeck, F. A.</creator><creator>Leegwater, P. A. J.</creator><creator>Herrmann, T.</creator><creator>Broere, F.</creator><creator>Rutten, V. P. M. G.</creator><creator>Willemse, T.</creator><creator>Van Rhijn, I.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7TM</scope></search><sort><creationdate>201306</creationdate><title>Tandem repeats modify the structure of the canine CD1D gene</title><author>Looringh van Beeck, F. A. ; Leegwater, P. A. J. ; Herrmann, T. ; Broere, F. ; Rutten, V. P. M. G. ; Willemse, T. ; Van Rhijn, I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3502-85807c3417bc5658b9ea54d5524cc5784dd1fdb91e04b9bf9e2e8030367261483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>Antigens, CD1d - genetics</topic><topic>Canis lupus</topic><topic>CD1</topic><topic>DNA, Complementary - genetics</topic><topic>dog</topic><topic>Dogs - genetics</topic><topic>Exons</topic><topic>Genome</topic><topic>microsatellite</topic><topic>Natural Killer T-Cells - metabolism</topic><topic>NKT cells</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology</topic><topic>simple sequence repeat</topic><topic>T cell receptors</topic><topic>Tandem Repeat Sequences</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Looringh van Beeck, F. A.</creatorcontrib><creatorcontrib>Leegwater, P. A. J.</creatorcontrib><creatorcontrib>Herrmann, T.</creatorcontrib><creatorcontrib>Broere, F.</creatorcontrib><creatorcontrib>Rutten, V. P. M. G.</creatorcontrib><creatorcontrib>Willemse, T.</creatorcontrib><creatorcontrib>Van Rhijn, I.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><jtitle>Animal genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Looringh van Beeck, F. A.</au><au>Leegwater, P. A. J.</au><au>Herrmann, T.</au><au>Broere, F.</au><au>Rutten, V. P. M. G.</au><au>Willemse, T.</au><au>Van Rhijn, I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tandem repeats modify the structure of the canine CD1D gene</atitle><jtitle>Animal genetics</jtitle><addtitle>Anim Genet</addtitle><date>2013-06</date><risdate>2013</risdate><volume>44</volume><issue>3</issue><spage>352</spage><epage>355</epage><pages>352-355</pages><issn>0268-9146</issn><eissn>1365-2052</eissn><coden>ANGEE3</coden><abstract>Summary
Among the CD1 proteins that present lipid antigens to T cells, CD1d is the only one that stimulates a population of T cells with an invariant T‐cell receptor known as NKT cells. Sequencing of a 722 nucleotide gap in the dog (Canis lupus familiaris) genome revealed that the canine CD1D gene lacks a sequence homologous to exon 2 of human CD1D, coding for the start codon and signal peptide. Also, the canine CD1D gene contains three different short tandem repeats that disrupt the expected gene structure. Because canine CD1D cDNA lacks sequences homologous to human exon 2 and 3, the functionality of canine CD1d protein may be affected, and this could have consequences for the development and activation of canine NKT cells.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>22988997</pmid><doi>10.1111/age.12002</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Antigens Antigens, CD1d - genetics Canis lupus CD1 DNA, Complementary - genetics dog Dogs - genetics Exons Genome microsatellite Natural Killer T-Cells - metabolism NKT cells Sequence Analysis, DNA Sequence Homology simple sequence repeat T cell receptors Tandem Repeat Sequences Transcription, Genetic |
| title | Tandem repeats modify the structure of the canine CD1D gene |
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