Somatostatin antagonist induces catalepsy in the aged rat

Rationale Extrapyramidal motor signs are the major features of Parkinson’s disease (PD). It is unclear whether there is a link between these signs and such PD-associated factors as brain somatostatin deficiency and aging. Objectives This study aimed to examine whether an inhibition of the brain soma...

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Veröffentlicht in:	Psychopharmacology 2013-05, Vol.227 (2), p.273-276
Hauptverfasser:	Ionov, Ilya D., Pushinskaya, Irina I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aging Animals Antagonist drugs Biomedical and Life Sciences Biomedicine Brain - drug effects Brain - metabolism Care and treatment Catalepsy Catalepsy - chemically induced Causes of Diagnosis Dosage and administration Dose-Response Relationship, Drug Evaluation Extrapyramidal system Haloperidol - toxicity Health aspects Hormone antagonists Hormones Injections, Intraventricular Intracerebroventricular administration Male Movement disorders Neurodegenerative diseases Neurosciences Octreotide Octreotide - pharmacology Original Investigation Parkinson Disease - physiopathology Parkinson's disease Peptides, Cyclic - administration & dosage Peptides, Cyclic - toxicity Pharmacology/Toxicology Psychiatry Rats Rats, Wistar Rodents Somatostatin
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