Somatostatin antagonist induces catalepsy in the aged rat
Rationale Extrapyramidal motor signs are the major features of Parkinson’s disease (PD). It is unclear whether there is a link between these signs and such PD-associated factors as brain somatostatin deficiency and aging. Objectives This study aimed to examine whether an inhibition of the brain soma...
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| Veröffentlicht in: | Psychopharmacology 2013-05, Vol.227 (2), p.273-276 |
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| creator | Ionov, Ilya D. Pushinskaya, Irina I. |
| description | Rationale
Extrapyramidal motor signs are the major features of Parkinson’s disease (PD). It is unclear whether there is a link between these signs and such PD-associated factors as brain somatostatin deficiency and aging.
Objectives
This study aimed to examine whether an inhibition of the brain somatostatin system can initiate catalepsy, a model of extrapyramidal disorders, in young and aged rats.
Methods
The animals of 100–110 and 540–560 days of age were used. Catalepsy was measured using the bar test. The inhibition of the brain somatostatin activity was simulated by intracerebroventricular administration of a somatostatin antagonist, cyclosomatostatin.
Results
Cyclosomatostatin dose-dependently induced catalepsy in aged, but not in young rats. The cataleptic response was reversed by a somatostatin analog, octreotide.
Conclusions
The combination of aging and brain somatostatin deficiency can lead to catalepsy in rats. Since both factors are frequently observed in PD patients, the present results might be of relevance for pathogenesis of extrapyramidal signs in this disease. |
| doi_str_mv | 10.1007/s00213-012-2961-0 |
| format | Article |
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Extrapyramidal motor signs are the major features of Parkinson’s disease (PD). It is unclear whether there is a link between these signs and such PD-associated factors as brain somatostatin deficiency and aging.
Objectives
This study aimed to examine whether an inhibition of the brain somatostatin system can initiate catalepsy, a model of extrapyramidal disorders, in young and aged rats.
Methods
The animals of 100–110 and 540–560 days of age were used. Catalepsy was measured using the bar test. The inhibition of the brain somatostatin activity was simulated by intracerebroventricular administration of a somatostatin antagonist, cyclosomatostatin.
Results
Cyclosomatostatin dose-dependently induced catalepsy in aged, but not in young rats. The cataleptic response was reversed by a somatostatin analog, octreotide.
Conclusions
The combination of aging and brain somatostatin deficiency can lead to catalepsy in rats. Since both factors are frequently observed in PD patients, the present results might be of relevance for pathogenesis of extrapyramidal signs in this disease.</description><identifier>ISSN: 0033-3158</identifier><identifier>EISSN: 1432-2072</identifier><identifier>DOI: 10.1007/s00213-012-2961-0</identifier><identifier>PMID: 23274508</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Age Factors ; Aging ; Animals ; Antagonist drugs ; Biomedical and Life Sciences ; Biomedicine ; Brain - drug effects ; Brain - metabolism ; Care and treatment ; Catalepsy ; Catalepsy - chemically induced ; Causes of ; Diagnosis ; Dosage and administration ; Dose-Response Relationship, Drug ; Evaluation ; Extrapyramidal system ; Haloperidol - toxicity ; Health aspects ; Hormone antagonists ; Hormones ; Injections, Intraventricular ; Intracerebroventricular administration ; Male ; Movement disorders ; Neurodegenerative diseases ; Neurosciences ; Octreotide ; Octreotide - pharmacology ; Original Investigation ; Parkinson Disease - physiopathology ; Parkinson's disease ; Peptides, Cyclic - administration & dosage ; Peptides, Cyclic - toxicity ; Pharmacology/Toxicology ; Psychiatry ; Rats ; Rats, Wistar ; Rodents ; Somatostatin</subject><ispartof>Psychopharmacology, 2013-05, Vol.227 (2), p.273-276</ispartof><rights>Springer-Verlag Berlin Heidelberg 2012</rights><rights>COPYRIGHT 2013 Springer</rights><rights>Springer-Verlag Berlin Heidelberg 2012.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-e9029c4ed881ad699bc589c2808e5ec99346e910892af47feefee4836dcb0e723</citedby><cites>FETCH-LOGICAL-c539t-e9029c4ed881ad699bc589c2808e5ec99346e910892af47feefee4836dcb0e723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00213-012-2961-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00213-012-2961-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23274508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ionov, Ilya D.</creatorcontrib><creatorcontrib>Pushinskaya, Irina I.</creatorcontrib><title>Somatostatin antagonist induces catalepsy in the aged rat</title><title>Psychopharmacology</title><addtitle>Psychopharmacology</addtitle><addtitle>Psychopharmacology (Berl)</addtitle><description>Rationale
Extrapyramidal motor signs are the major features of Parkinson’s disease (PD). It is unclear whether there is a link between these signs and such PD-associated factors as brain somatostatin deficiency and aging.
Objectives
This study aimed to examine whether an inhibition of the brain somatostatin system can initiate catalepsy, a model of extrapyramidal disorders, in young and aged rats.
Methods
The animals of 100–110 and 540–560 days of age were used. Catalepsy was measured using the bar test. The inhibition of the brain somatostatin activity was simulated by intracerebroventricular administration of a somatostatin antagonist, cyclosomatostatin.
Results
Cyclosomatostatin dose-dependently induced catalepsy in aged, but not in young rats. The cataleptic response was reversed by a somatostatin analog, octreotide.
Conclusions
The combination of aging and brain somatostatin deficiency can lead to catalepsy in rats. Since both factors are frequently observed in PD patients, the present results might be of relevance for pathogenesis of extrapyramidal signs in this disease.</description><subject>Age Factors</subject><subject>Aging</subject><subject>Animals</subject><subject>Antagonist drugs</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Care and treatment</subject><subject>Catalepsy</subject><subject>Catalepsy - chemically induced</subject><subject>Causes of</subject><subject>Diagnosis</subject><subject>Dosage and administration</subject><subject>Dose-Response Relationship, Drug</subject><subject>Evaluation</subject><subject>Extrapyramidal system</subject><subject>Haloperidol - toxicity</subject><subject>Health aspects</subject><subject>Hormone antagonists</subject><subject>Hormones</subject><subject>Injections, Intraventricular</subject><subject>Intracerebroventricular administration</subject><subject>Male</subject><subject>Movement disorders</subject><subject>Neurodegenerative diseases</subject><subject>Neurosciences</subject><subject>Octreotide</subject><subject>Octreotide - pharmacology</subject><subject>Original Investigation</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson's disease</subject><subject>Peptides, Cyclic - administration & dosage</subject><subject>Peptides, Cyclic - toxicity</subject><subject>Pharmacology/Toxicology</subject><subject>Psychiatry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Somatostatin</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkk1PJCEQhonR6Kz6A_ZiOvHipcfio7vhaMyubmLiQT0Thq6ebTMNI9AH_71MZtRxsxqBhFA8VUUVLyE_KUwpQHMeARjlJVBWMlXTEnbIhAqeT9CwXTIB4LzktJIH5EeMj5CHkGKfHDDOGlGBnBB15weTfEwm9a4wLpm5d31MRe_a0WIsrElmgcv4nC1F-ouFmWNbBJOOyF5nFhGPN_shefj96_7yury5vfpzeXFT2oqrVKICpqzAVkpq2lqpma2kskyCxAqtUlzUqChIxUwnmg4xLyF53doZYMP4ITlbx10G_zRiTHroo8XFwjj0Y9SUV4wpWgue0dN_0Ec_BpdflylRU5VLrt6peS5M967zKRi7CqovGhA1z92BLynOGyqrhslMTf9D5dni0FvvsOuz_UPYbzlsZ6BrBxt8jAE7vQz9YMKzpqBXKtBrFeisAr1SgV4lOdn0YZwN2L55vH57BtgaiPnKzTFsNerTqC-Ydbe6</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Ionov, Ilya D.</creator><creator>Pushinskaya, Irina I.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20130501</creationdate><title>Somatostatin antagonist induces catalepsy in the aged rat</title><author>Ionov, Ilya D. ; Pushinskaya, Irina I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-e9029c4ed881ad699bc589c2808e5ec99346e910892af47feefee4836dcb0e723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Age Factors</topic><topic>Aging</topic><topic>Animals</topic><topic>Antagonist drugs</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Care and treatment</topic><topic>Catalepsy</topic><topic>Catalepsy - chemically induced</topic><topic>Causes of</topic><topic>Diagnosis</topic><topic>Dosage and administration</topic><topic>Dose-Response Relationship, Drug</topic><topic>Evaluation</topic><topic>Extrapyramidal system</topic><topic>Haloperidol - toxicity</topic><topic>Health aspects</topic><topic>Hormone antagonists</topic><topic>Hormones</topic><topic>Injections, Intraventricular</topic><topic>Intracerebroventricular administration</topic><topic>Male</topic><topic>Movement disorders</topic><topic>Neurodegenerative diseases</topic><topic>Neurosciences</topic><topic>Octreotide</topic><topic>Octreotide - pharmacology</topic><topic>Original Investigation</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson's disease</topic><topic>Peptides, Cyclic - administration & dosage</topic><topic>Peptides, Cyclic - toxicity</topic><topic>Pharmacology/Toxicology</topic><topic>Psychiatry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Somatostatin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ionov, Ilya D.</creatorcontrib><creatorcontrib>Pushinskaya, Irina I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ionov, Ilya D.</au><au>Pushinskaya, Irina I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Somatostatin antagonist induces catalepsy in the aged rat</atitle><jtitle>Psychopharmacology</jtitle><stitle>Psychopharmacology</stitle><addtitle>Psychopharmacology (Berl)</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>227</volume><issue>2</issue><spage>273</spage><epage>276</epage><pages>273-276</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><abstract>Rationale
Extrapyramidal motor signs are the major features of Parkinson’s disease (PD). It is unclear whether there is a link between these signs and such PD-associated factors as brain somatostatin deficiency and aging.
Objectives
This study aimed to examine whether an inhibition of the brain somatostatin system can initiate catalepsy, a model of extrapyramidal disorders, in young and aged rats.
Methods
The animals of 100–110 and 540–560 days of age were used. Catalepsy was measured using the bar test. The inhibition of the brain somatostatin activity was simulated by intracerebroventricular administration of a somatostatin antagonist, cyclosomatostatin.
Results
Cyclosomatostatin dose-dependently induced catalepsy in aged, but not in young rats. The cataleptic response was reversed by a somatostatin analog, octreotide.
Conclusions
The combination of aging and brain somatostatin deficiency can lead to catalepsy in rats. Since both factors are frequently observed in PD patients, the present results might be of relevance for pathogenesis of extrapyramidal signs in this disease.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>23274508</pmid><doi>10.1007/s00213-012-2961-0</doi><tpages>4</tpages></addata></record> |
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| ispartof | Psychopharmacology, 2013-05, Vol.227 (2), p.273-276 |
| issn | 0033-3158 1432-2072 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Age Factors Aging Animals Antagonist drugs Biomedical and Life Sciences Biomedicine Brain - drug effects Brain - metabolism Care and treatment Catalepsy Catalepsy - chemically induced Causes of Diagnosis Dosage and administration Dose-Response Relationship, Drug Evaluation Extrapyramidal system Haloperidol - toxicity Health aspects Hormone antagonists Hormones Injections, Intraventricular Intracerebroventricular administration Male Movement disorders Neurodegenerative diseases Neurosciences Octreotide Octreotide - pharmacology Original Investigation Parkinson Disease - physiopathology Parkinson's disease Peptides, Cyclic - administration & dosage Peptides, Cyclic - toxicity Pharmacology/Toxicology Psychiatry Rats Rats, Wistar Rodents Somatostatin |
| title | Somatostatin antagonist induces catalepsy in the aged rat |
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