Low-level laser therapy improves the inflammatory profile of rats with heart failure
Following heart failure (HF), immune activation leads to an imbalance between pro-inflammatory and anti-inflammatory cytokines. Low-level laser therapy (LLLT) has been used as an anti-inflammatory treatment in several disease conditions. However, the effect of LLLT on the skeletal muscle of rats wit...
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| description | Following heart failure (HF), immune activation leads to an imbalance between pro-inflammatory and anti-inflammatory cytokines. Low-level laser therapy (LLLT) has been used as an anti-inflammatory treatment in several disease conditions. However, the effect of LLLT on the skeletal muscle of rats with HF remains unclear. The present report aimed to evaluate the influence of LLLT on the inflammatory profile of rats with HF. The left coronary artery was ligated to induce HF and a sham operation was performed in the control groups. Male Wistar rats (
n
= 49) were assigned to one of six groups: placebo sham rats (P-Sham;
n
= 8), LLLT at a dose of 3 J/cm
2
sham rats (3 J/cm
2
-Sham;
n
= 8), LLLT at a dose of 21 J/cm
2
sham rats (21 J/cm
2
-Sham;
n
= 8), placebo HF rats (P-HF;
n
= 9), LLLT at a dose of 3 J/cm
2
HF rats (3 J/cm
2
-HF;
n
= 8), and LLLT at a dose of 21 J/cm
2
HF rats (21 J/cm
2
-HF;
n
= 8). Four weeks after myocardial infarction or sham surgery, rats were subjected to LLLT (InGaAlP 660 nm, spot size 0.035 cm
2
, output power 20 mW, power density 0.571 W/cm
2
, energy density 3 or 21 J/cm
2
, exposure time 5.25 s and 36.75 s) on the right gastrocnemius for 10 consecutive days. LLLT reduced plasma IL-6 levels (61.3 %;
P
|
| doi_str_mv | 10.1007/s10103-012-1190-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1352290808</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1347259027</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-954a02b3b7aab00f26b455af7c80b2890a5ecbee27a8115c3ee2ad7491147ee93</originalsourceid><addsrcrecordid>eNqNkVFrFDEQx4Mo9lr9AL5IwBdfojPZZLN5lFKtcNCXFvoWZrez3pbs7Znstty3N8dVEUHoU8LkN__J8BPiHcInBHCfMwJCpQC1QvSgzAuxQlNZVYO5fSlWoOtGNV7jiTjN-R4AXY3Va3Gita9qU-NKXK-nRxX5gaOMlDnJecOJdns5jLs0PXA-FOSw7SONI81T2stS74fIcuplojnLx2HeyA1TmmVPQ1wSvxGveoqZ3z6dZ-Lm68X1-aVaX337fv5lrToDdlbeGgLdVq0jagF6XbfGWupd10CrGw9kuWuZtaMG0XZVudKdMx7ROGZfnYmPx9zypZ8L5zmMQ-44RtrytOSAlS2bQgPNM1DjtPWgXUE__IPeT0valkUOVG280TUUCo9Ul6acE_dhl4aR0j4ghIOdcLQTip1wsBNM6Xn_lLy0I9_96fitowD6COTytP3B6a_R_039BXVRmWc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1346494260</pqid></control><display><type>article</type><title>Low-level laser therapy improves the inflammatory profile of rats with heart failure</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Hentschke, Vítor S. ; Jaenisch, Rodrigo B. ; Schmeing, Letiane A. ; Cavinato, Paulo R. ; Xavier, Leder L. ; Dal Lago, Pedro</creator><creatorcontrib>Hentschke, Vítor S. ; Jaenisch, Rodrigo B. ; Schmeing, Letiane A. ; Cavinato, Paulo R. ; Xavier, Leder L. ; Dal Lago, Pedro</creatorcontrib><description><![CDATA[Following heart failure (HF), immune activation leads to an imbalance between pro-inflammatory and anti-inflammatory cytokines. Low-level laser therapy (LLLT) has been used as an anti-inflammatory treatment in several disease conditions. However, the effect of LLLT on the skeletal muscle of rats with HF remains unclear. The present report aimed to evaluate the influence of LLLT on the inflammatory profile of rats with HF. The left coronary artery was ligated to induce HF and a sham operation was performed in the control groups. Male Wistar rats (
n
= 49) were assigned to one of six groups: placebo sham rats (P-Sham;
n
= 8), LLLT at a dose of 3 J/cm
2
sham rats (3 J/cm
2
-Sham;
n
= 8), LLLT at a dose of 21 J/cm
2
sham rats (21 J/cm
2
-Sham;
n
= 8), placebo HF rats (P-HF;
n
= 9), LLLT at a dose of 3 J/cm
2
HF rats (3 J/cm
2
-HF;
n
= 8), and LLLT at a dose of 21 J/cm
2
HF rats (21 J/cm
2
-HF;
n
= 8). Four weeks after myocardial infarction or sham surgery, rats were subjected to LLLT (InGaAlP 660 nm, spot size 0.035 cm
2
, output power 20 mW, power density 0.571 W/cm
2
, energy density 3 or 21 J/cm
2
, exposure time 5.25 s and 36.75 s) on the right gastrocnemius for 10 consecutive days. LLLT reduced plasma IL-6 levels (61.3 %;
P
< 0.01), TNF-α/IL-10 (61.0 %;
P
< 0.01) and IL-6/IL-10 ratios (77.3 %;
P
< 0.001) and increased IL-10 levels (103 %;
P
< 0.05) in the 21 J/cm
2
-HF group. Moreover, LLLT reduced the TNF-α (20.1 % and 21.3 %; both
P
< 0.05) and IL-6 levels (54.3 % and 37.8 %;
P
< 0.01 and
P
< 0.05, respectively) and the IL-6/IL-10 ratio (59.7 % and 42.2 %;
P
< 0.001 and
P
< 0.05, respectively) and increased IL-10 levels (81.0 % and 85.1 %; both
P
< 0.05) and the IL-10/TNF-α ratio (171.5 % and 119.8 %;
P
< 0.001 and
P
< 0.05, respectively) in the gastrocnemius in the 3 J/cm
2
-HF and 21 J/cm
2
-HF groups. LLLT showed systemic and skeletal muscle anti-inflammatory effects in rats with HF.]]></description><identifier>ISSN: 0268-8921</identifier><identifier>EISSN: 1435-604X</identifier><identifier>DOI: 10.1007/s10103-012-1190-4</identifier><identifier>PMID: 22936461</identifier><identifier>CODEN: LMSCEZ</identifier><language>eng</language><publisher>London: Springer-Verlag</publisher><subject>Animals ; Cytokines ; Dentistry ; Heart failure ; Heart Failure - etiology ; Heart Failure - immunology ; Heart Failure - radiotherapy ; Inflammation - etiology ; Inflammation - immunology ; Inflammation - radiotherapy ; Inflammation Mediators - blood ; Inflammation Mediators - metabolism ; Interleukin-10 - blood ; Interleukin-10 - metabolism ; Interleukin-6 - blood ; Interleukin-6 - metabolism ; Lasers ; Low-Level Light Therapy ; Male ; Medicine ; Medicine & Public Health ; Muscle, Skeletal - immunology ; Muscle, Skeletal - radiation effects ; Myocardial Infarction - complications ; Optical Devices ; Optics ; Original Article ; Photonics ; Quantum Optics ; Rats ; Rats, Wistar ; Rodents ; Tumor Necrosis Factor-alpha - blood ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>Lasers in medical science, 2013-05, Vol.28 (3), p.1007-1016</ispartof><rights>Springer-Verlag London Ltd 2012</rights><rights>Springer-Verlag London 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-954a02b3b7aab00f26b455af7c80b2890a5ecbee27a8115c3ee2ad7491147ee93</citedby><cites>FETCH-LOGICAL-c405t-954a02b3b7aab00f26b455af7c80b2890a5ecbee27a8115c3ee2ad7491147ee93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10103-012-1190-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10103-012-1190-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22936461$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hentschke, Vítor S.</creatorcontrib><creatorcontrib>Jaenisch, Rodrigo B.</creatorcontrib><creatorcontrib>Schmeing, Letiane A.</creatorcontrib><creatorcontrib>Cavinato, Paulo R.</creatorcontrib><creatorcontrib>Xavier, Leder L.</creatorcontrib><creatorcontrib>Dal Lago, Pedro</creatorcontrib><title>Low-level laser therapy improves the inflammatory profile of rats with heart failure</title><title>Lasers in medical science</title><addtitle>Lasers Med Sci</addtitle><addtitle>Lasers Med Sci</addtitle><description><![CDATA[Following heart failure (HF), immune activation leads to an imbalance between pro-inflammatory and anti-inflammatory cytokines. Low-level laser therapy (LLLT) has been used as an anti-inflammatory treatment in several disease conditions. However, the effect of LLLT on the skeletal muscle of rats with HF remains unclear. The present report aimed to evaluate the influence of LLLT on the inflammatory profile of rats with HF. The left coronary artery was ligated to induce HF and a sham operation was performed in the control groups. Male Wistar rats (
n
= 49) were assigned to one of six groups: placebo sham rats (P-Sham;
n
= 8), LLLT at a dose of 3 J/cm
2
sham rats (3 J/cm
2
-Sham;
n
= 8), LLLT at a dose of 21 J/cm
2
sham rats (21 J/cm
2
-Sham;
n
= 8), placebo HF rats (P-HF;
n
= 9), LLLT at a dose of 3 J/cm
2
HF rats (3 J/cm
2
-HF;
n
= 8), and LLLT at a dose of 21 J/cm
2
HF rats (21 J/cm
2
-HF;
n
= 8). Four weeks after myocardial infarction or sham surgery, rats were subjected to LLLT (InGaAlP 660 nm, spot size 0.035 cm
2
, output power 20 mW, power density 0.571 W/cm
2
, energy density 3 or 21 J/cm
2
, exposure time 5.25 s and 36.75 s) on the right gastrocnemius for 10 consecutive days. LLLT reduced plasma IL-6 levels (61.3 %;
P
< 0.01), TNF-α/IL-10 (61.0 %;
P
< 0.01) and IL-6/IL-10 ratios (77.3 %;
P
< 0.001) and increased IL-10 levels (103 %;
P
< 0.05) in the 21 J/cm
2
-HF group. Moreover, LLLT reduced the TNF-α (20.1 % and 21.3 %; both
P
< 0.05) and IL-6 levels (54.3 % and 37.8 %;
P
< 0.01 and
P
< 0.05, respectively) and the IL-6/IL-10 ratio (59.7 % and 42.2 %;
P
< 0.001 and
P
< 0.05, respectively) and increased IL-10 levels (81.0 % and 85.1 %; both
P
< 0.05) and the IL-10/TNF-α ratio (171.5 % and 119.8 %;
P
< 0.001 and
P
< 0.05, respectively) in the gastrocnemius in the 3 J/cm
2
-HF and 21 J/cm
2
-HF groups. LLLT showed systemic and skeletal muscle anti-inflammatory effects in rats with HF.]]></description><subject>Animals</subject><subject>Cytokines</subject><subject>Dentistry</subject><subject>Heart failure</subject><subject>Heart Failure - etiology</subject><subject>Heart Failure - immunology</subject><subject>Heart Failure - radiotherapy</subject><subject>Inflammation - etiology</subject><subject>Inflammation - immunology</subject><subject>Inflammation - radiotherapy</subject><subject>Inflammation Mediators - blood</subject><subject>Inflammation Mediators - metabolism</subject><subject>Interleukin-10 - blood</subject><subject>Interleukin-10 - metabolism</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-6 - metabolism</subject><subject>Lasers</subject><subject>Low-Level Light Therapy</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Muscle, Skeletal - immunology</subject><subject>Muscle, Skeletal - radiation effects</subject><subject>Myocardial Infarction - complications</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Original Article</subject><subject>Photonics</subject><subject>Quantum Optics</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>0268-8921</issn><issn>1435-604X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkVFrFDEQx4Mo9lr9AL5IwBdfojPZZLN5lFKtcNCXFvoWZrez3pbs7Znstty3N8dVEUHoU8LkN__J8BPiHcInBHCfMwJCpQC1QvSgzAuxQlNZVYO5fSlWoOtGNV7jiTjN-R4AXY3Va3Gita9qU-NKXK-nRxX5gaOMlDnJecOJdns5jLs0PXA-FOSw7SONI81T2stS74fIcuplojnLx2HeyA1TmmVPQ1wSvxGveoqZ3z6dZ-Lm68X1-aVaX337fv5lrToDdlbeGgLdVq0jagF6XbfGWupd10CrGw9kuWuZtaMG0XZVudKdMx7ROGZfnYmPx9zypZ8L5zmMQ-44RtrytOSAlS2bQgPNM1DjtPWgXUE__IPeT0valkUOVG280TUUCo9Ul6acE_dhl4aR0j4ghIOdcLQTip1wsBNM6Xn_lLy0I9_96fitowD6COTytP3B6a_R_039BXVRmWc</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Hentschke, Vítor S.</creator><creator>Jaenisch, Rodrigo B.</creator><creator>Schmeing, Letiane A.</creator><creator>Cavinato, Paulo R.</creator><creator>Xavier, Leder L.</creator><creator>Dal Lago, Pedro</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7SP</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>L7M</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20130501</creationdate><title>Low-level laser therapy improves the inflammatory profile of rats with heart failure</title><author>Hentschke, Vítor S. ; Jaenisch, Rodrigo B. ; Schmeing, Letiane A. ; Cavinato, Paulo R. ; Xavier, Leder L. ; Dal Lago, Pedro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-954a02b3b7aab00f26b455af7c80b2890a5ecbee27a8115c3ee2ad7491147ee93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Cytokines</topic><topic>Dentistry</topic><topic>Heart failure</topic><topic>Heart Failure - etiology</topic><topic>Heart Failure - immunology</topic><topic>Heart Failure - radiotherapy</topic><topic>Inflammation - etiology</topic><topic>Inflammation - immunology</topic><topic>Inflammation - radiotherapy</topic><topic>Inflammation Mediators - blood</topic><topic>Inflammation Mediators - metabolism</topic><topic>Interleukin-10 - blood</topic><topic>Interleukin-10 - metabolism</topic><topic>Interleukin-6 - blood</topic><topic>Interleukin-6 - metabolism</topic><topic>Lasers</topic><topic>Low-Level Light Therapy</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Muscle, Skeletal - immunology</topic><topic>Muscle, Skeletal - radiation effects</topic><topic>Myocardial Infarction - complications</topic><topic>Optical Devices</topic><topic>Optics</topic><topic>Original Article</topic><topic>Photonics</topic><topic>Quantum Optics</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hentschke, Vítor S.</creatorcontrib><creatorcontrib>Jaenisch, Rodrigo B.</creatorcontrib><creatorcontrib>Schmeing, Letiane A.</creatorcontrib><creatorcontrib>Cavinato, Paulo R.</creatorcontrib><creatorcontrib>Xavier, Leder L.</creatorcontrib><creatorcontrib>Dal Lago, Pedro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aerospace Database</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Lasers in medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hentschke, Vítor S.</au><au>Jaenisch, Rodrigo B.</au><au>Schmeing, Letiane A.</au><au>Cavinato, Paulo R.</au><au>Xavier, Leder L.</au><au>Dal Lago, Pedro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low-level laser therapy improves the inflammatory profile of rats with heart failure</atitle><jtitle>Lasers in medical science</jtitle><stitle>Lasers Med Sci</stitle><addtitle>Lasers Med Sci</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>28</volume><issue>3</issue><spage>1007</spage><epage>1016</epage><pages>1007-1016</pages><issn>0268-8921</issn><eissn>1435-604X</eissn><coden>LMSCEZ</coden><abstract><![CDATA[Following heart failure (HF), immune activation leads to an imbalance between pro-inflammatory and anti-inflammatory cytokines. Low-level laser therapy (LLLT) has been used as an anti-inflammatory treatment in several disease conditions. However, the effect of LLLT on the skeletal muscle of rats with HF remains unclear. The present report aimed to evaluate the influence of LLLT on the inflammatory profile of rats with HF. The left coronary artery was ligated to induce HF and a sham operation was performed in the control groups. Male Wistar rats (
n
= 49) were assigned to one of six groups: placebo sham rats (P-Sham;
n
= 8), LLLT at a dose of 3 J/cm
2
sham rats (3 J/cm
2
-Sham;
n
= 8), LLLT at a dose of 21 J/cm
2
sham rats (21 J/cm
2
-Sham;
n
= 8), placebo HF rats (P-HF;
n
= 9), LLLT at a dose of 3 J/cm
2
HF rats (3 J/cm
2
-HF;
n
= 8), and LLLT at a dose of 21 J/cm
2
HF rats (21 J/cm
2
-HF;
n
= 8). Four weeks after myocardial infarction or sham surgery, rats were subjected to LLLT (InGaAlP 660 nm, spot size 0.035 cm
2
, output power 20 mW, power density 0.571 W/cm
2
, energy density 3 or 21 J/cm
2
, exposure time 5.25 s and 36.75 s) on the right gastrocnemius for 10 consecutive days. LLLT reduced plasma IL-6 levels (61.3 %;
P
< 0.01), TNF-α/IL-10 (61.0 %;
P
< 0.01) and IL-6/IL-10 ratios (77.3 %;
P
< 0.001) and increased IL-10 levels (103 %;
P
< 0.05) in the 21 J/cm
2
-HF group. Moreover, LLLT reduced the TNF-α (20.1 % and 21.3 %; both
P
< 0.05) and IL-6 levels (54.3 % and 37.8 %;
P
< 0.01 and
P
< 0.05, respectively) and the IL-6/IL-10 ratio (59.7 % and 42.2 %;
P
< 0.001 and
P
< 0.05, respectively) and increased IL-10 levels (81.0 % and 85.1 %; both
P
< 0.05) and the IL-10/TNF-α ratio (171.5 % and 119.8 %;
P
< 0.001 and
P
< 0.05, respectively) in the gastrocnemius in the 3 J/cm
2
-HF and 21 J/cm
2
-HF groups. LLLT showed systemic and skeletal muscle anti-inflammatory effects in rats with HF.]]></abstract><cop>London</cop><pub>Springer-Verlag</pub><pmid>22936461</pmid><doi>10.1007/s10103-012-1190-4</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0268-8921 |
| ispartof | Lasers in medical science, 2013-05, Vol.28 (3), p.1007-1016 |
| issn | 0268-8921 1435-604X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1352290808 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Animals Cytokines Dentistry Heart failure Heart Failure - etiology Heart Failure - immunology Heart Failure - radiotherapy Inflammation - etiology Inflammation - immunology Inflammation - radiotherapy Inflammation Mediators - blood Inflammation Mediators - metabolism Interleukin-10 - blood Interleukin-10 - metabolism Interleukin-6 - blood Interleukin-6 - metabolism Lasers Low-Level Light Therapy Male Medicine Medicine & Public Health Muscle, Skeletal - immunology Muscle, Skeletal - radiation effects Myocardial Infarction - complications Optical Devices Optics Original Article Photonics Quantum Optics Rats Rats, Wistar Rodents Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - metabolism |
| title | Low-level laser therapy improves the inflammatory profile of rats with heart failure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T19%3A39%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Low-level%20laser%20therapy%20improves%20the%20inflammatory%20profile%20of%20rats%20with%20heart%20failure&rft.jtitle=Lasers%20in%20medical%20science&rft.au=Hentschke,%20V%C3%ADtor%20S.&rft.date=2013-05-01&rft.volume=28&rft.issue=3&rft.spage=1007&rft.epage=1016&rft.pages=1007-1016&rft.issn=0268-8921&rft.eissn=1435-604X&rft.coden=LMSCEZ&rft_id=info:doi/10.1007/s10103-012-1190-4&rft_dat=%3Cproquest_cross%3E1347259027%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1346494260&rft_id=info:pmid/22936461&rfr_iscdi=true |