Interaction between neonatal allopregnanolone administration and early maternal separation: Effects on adolescent and adult behaviors in male rat
Endogenous neurosteroid level fluctuations are related to several emotional and behavioral alterations. Neurosteroids also have important roles during neurodevelopment, with there being a relationship between modification of their levels in neurodevelopmental periods and behavioral alterations in ad...
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| Veröffentlicht in: | Hormones and behavior 2013-04, Vol.63 (4), p.577-585 |
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| description | Endogenous neurosteroid level fluctuations are related to several emotional and behavioral alterations. Neurosteroids also have important roles during neurodevelopment, with there being a relationship between modification of their levels in neurodevelopmental periods and behavioral alterations in adolescence and adulthood. Early maternal separation (EMS) is a stressful event that also alters neurodevelopment and adolescent and adult behaviors. The aim of the present study is to analyze the interaction between the effects of the neonatal alteration of allopregnanolone (AlloP), neurosteroid that increase its levels after acute stress presentation, and EMS on adolescent exploration and adult anxiety and sensorimotor gating in male rats. AlloP (10mg/kgs.c.) was administrated between postnatal day 5 (PN5) and PN9, and a single 24-hour period of EMS was carried out on PN9. Exploration was analyzed at PN40 and PN60. At adult age (PN85), anxiety was tested by means of the elevated plus-maze test (EPM), and sensorimotor gating by means of prepulse inhibition test (PPI). PPI deterioration has been considered as a reliable indicator of diseases such as schizophrenia. Results showed that the previous neonatal AlloP administration neutralized the effects of EMS in the adolescent exploration (increase of traveled distance and decrease of head-dips). In adult age, an anxiolytic-like profile was observed as a consequence of EMS. Finally, EMS and neonatal AlloP disrupted PPI. Taken together, these data show the important role that physiological neonatal AlloP levels and stressful events play in neural development, adult behavior and vulnerability to neurodevelopmental disorders such as schizophrenia.
► Early maternal separation (EMS) induces anxiogenic-like profile in the adolescence. ► Neonatal AlloP administration prevents anxiogenic effects of EMS in the adolescence. ► Early maternal separation (EMS) induces anxiolytic-like profile in the adult age. ► EMS and neonatal AlloP administration deteriorate prepulse inhibition in adulthood. ► Neonatal AlloP levels and stress can determine vulnerability to emotional disorders. |
| doi_str_mv | 10.1016/j.yhbeh.2013.02.002 |
| format | Article |
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► Early maternal separation (EMS) induces anxiogenic-like profile in the adolescence. ► Neonatal AlloP administration prevents anxiogenic effects of EMS in the adolescence. ► Early maternal separation (EMS) induces anxiolytic-like profile in the adult age. ► EMS and neonatal AlloP administration deteriorate prepulse inhibition in adulthood. ► Neonatal AlloP levels and stress can determine vulnerability to emotional disorders.</description><identifier>ISSN: 0018-506X</identifier><identifier>EISSN: 1095-6867</identifier><identifier>DOI: 10.1016/j.yhbeh.2013.02.002</identifier><identifier>PMID: 23410958</identifier><identifier>CODEN: HOBEAO</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Aging - physiology ; Allopregnanolone ; Animal behavior ; Animals ; Animals, Newborn ; Anxiety ; Anxiety - psychology ; Anxiety, Separation - psychology ; Behavioral psychophysiology ; Biological and medical sciences ; Body Weight - drug effects ; Early maternal separation ; Exploratory Behavior - drug effects ; Fundamental and applied biological sciences. Psychology ; Gonadal Steroid Hormones - pharmacology ; Hormones and behavior ; Male ; Maternal Deprivation ; Neurodevelopment ; Neurosteroids ; Novelty exploration ; Pregnanolone - pharmacology ; Prepulse inhibition ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Reflex, Startle - drug effects ; Rodents ; Steroids ; Stress</subject><ispartof>Hormones and behavior, 2013-04, Vol.63 (4), p.577-585</ispartof><rights>2013 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-a4f8e688d1f3962a65d549f562a6fb10acb49150acb1042aa9bff80a08b22cc73</citedby><cites>FETCH-LOGICAL-c450t-a4f8e688d1f3962a65d549f562a6fb10acb49150acb1042aa9bff80a08b22cc73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.yhbeh.2013.02.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27353686$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23410958$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Llidó, Anna</creatorcontrib><creatorcontrib>Mòdol, Laura</creatorcontrib><creatorcontrib>Darbra, Sònia</creatorcontrib><creatorcontrib>Pallarès, Marc</creatorcontrib><title>Interaction between neonatal allopregnanolone administration and early maternal separation: Effects on adolescent and adult behaviors in male rat</title><title>Hormones and behavior</title><addtitle>Horm Behav</addtitle><description>Endogenous neurosteroid level fluctuations are related to several emotional and behavioral alterations. Neurosteroids also have important roles during neurodevelopment, with there being a relationship between modification of their levels in neurodevelopmental periods and behavioral alterations in adolescence and adulthood. Early maternal separation (EMS) is a stressful event that also alters neurodevelopment and adolescent and adult behaviors. The aim of the present study is to analyze the interaction between the effects of the neonatal alteration of allopregnanolone (AlloP), neurosteroid that increase its levels after acute stress presentation, and EMS on adolescent exploration and adult anxiety and sensorimotor gating in male rats. AlloP (10mg/kgs.c.) was administrated between postnatal day 5 (PN5) and PN9, and a single 24-hour period of EMS was carried out on PN9. Exploration was analyzed at PN40 and PN60. At adult age (PN85), anxiety was tested by means of the elevated plus-maze test (EPM), and sensorimotor gating by means of prepulse inhibition test (PPI). PPI deterioration has been considered as a reliable indicator of diseases such as schizophrenia. Results showed that the previous neonatal AlloP administration neutralized the effects of EMS in the adolescent exploration (increase of traveled distance and decrease of head-dips). In adult age, an anxiolytic-like profile was observed as a consequence of EMS. Finally, EMS and neonatal AlloP disrupted PPI. Taken together, these data show the important role that physiological neonatal AlloP levels and stressful events play in neural development, adult behavior and vulnerability to neurodevelopmental disorders such as schizophrenia.
► Early maternal separation (EMS) induces anxiogenic-like profile in the adolescence. ► Neonatal AlloP administration prevents anxiogenic effects of EMS in the adolescence. ► Early maternal separation (EMS) induces anxiolytic-like profile in the adult age. ► EMS and neonatal AlloP administration deteriorate prepulse inhibition in adulthood. ► Neonatal AlloP levels and stress can determine vulnerability to emotional disorders.</description><subject>Aging - physiology</subject><subject>Allopregnanolone</subject><subject>Animal behavior</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Anxiety</subject><subject>Anxiety - psychology</subject><subject>Anxiety, Separation - psychology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Early maternal separation</subject><subject>Exploratory Behavior - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gonadal Steroid Hormones - pharmacology</subject><subject>Hormones and behavior</subject><subject>Male</subject><subject>Maternal Deprivation</subject><subject>Neurodevelopment</subject><subject>Neurosteroids</subject><subject>Novelty exploration</subject><subject>Pregnanolone - pharmacology</subject><subject>Prepulse inhibition</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Reflex, Startle - drug effects</subject><subject>Rodents</subject><subject>Steroids</subject><subject>Stress</subject><issn>0018-506X</issn><issn>1095-6867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkt-K1DAUxoso7rj6BIIURPCmNX-aNhW8kGXVhQVvFLwLp-mJkyFNxqRdmcfwjU1nRgUvxKuTkN_35eR8KYqnlNSU0PbVrj5sB9zWjFBeE1YTwu4VG0p6UbWy7e4XG0KorARpv1wUj1La5S0VTfOwuGC8WTm5KX7c-Bkj6NkGXw44f0f0pcfgYQZXgnNhH_GrBx9c8FjCOFlv0xzhKAA_lgjRHcoJso3PkoR7OJ2-Lq-NQT2nciXH4DBp9PNRBOPi5nzfFu5siKm0Pjs4LLPycfHAgEv45Fwvi8_vrj9dfahuP76_uXp7W-lGkLmCxkhspRyp4X3LoBWjaHoj1qUZKAE9ND0Va6WkYQD9YIwkQOTAmNYdvyxennz3MXxbMM1qsrlB5yA_f0mKcsGY7Chj_4FyyXvOuyajz_9Cd2FZB7NSTApO5dGQnygdQ0oRjdpHO0E8KErUGq7aqWO4ag1XEaZyuFn17Oy9DBOOvzW_0szAizMASYMzEby26Q_XccHz18jcmxOHeb53FqNK2qLXONqYA1NjsP9s5Cfi-MWo</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Llidó, Anna</creator><creator>Mòdol, Laura</creator><creator>Darbra, Sònia</creator><creator>Pallarès, Marc</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier BV</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20130401</creationdate><title>Interaction between neonatal allopregnanolone administration and early maternal separation: Effects on adolescent and adult behaviors in male rat</title><author>Llidó, Anna ; Mòdol, Laura ; Darbra, Sònia ; Pallarès, Marc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-a4f8e688d1f3962a65d549f562a6fb10acb49150acb1042aa9bff80a08b22cc73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aging - physiology</topic><topic>Allopregnanolone</topic><topic>Animal behavior</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Anxiety</topic><topic>Anxiety - psychology</topic><topic>Anxiety, Separation - psychology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Early maternal separation</topic><topic>Exploratory Behavior - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gonadal Steroid Hormones - pharmacology</topic><topic>Hormones and behavior</topic><topic>Male</topic><topic>Maternal Deprivation</topic><topic>Neurodevelopment</topic><topic>Neurosteroids</topic><topic>Novelty exploration</topic><topic>Pregnanolone - pharmacology</topic><topic>Prepulse inhibition</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Reflex, Startle - drug effects</topic><topic>Rodents</topic><topic>Steroids</topic><topic>Stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Llidó, Anna</creatorcontrib><creatorcontrib>Mòdol, Laura</creatorcontrib><creatorcontrib>Darbra, Sònia</creatorcontrib><creatorcontrib>Pallarès, Marc</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Hormones and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Llidó, Anna</au><au>Mòdol, Laura</au><au>Darbra, Sònia</au><au>Pallarès, Marc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction between neonatal allopregnanolone administration and early maternal separation: Effects on adolescent and adult behaviors in male rat</atitle><jtitle>Hormones and behavior</jtitle><addtitle>Horm Behav</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>63</volume><issue>4</issue><spage>577</spage><epage>585</epage><pages>577-585</pages><issn>0018-506X</issn><eissn>1095-6867</eissn><coden>HOBEAO</coden><abstract>Endogenous neurosteroid level fluctuations are related to several emotional and behavioral alterations. Neurosteroids also have important roles during neurodevelopment, with there being a relationship between modification of their levels in neurodevelopmental periods and behavioral alterations in adolescence and adulthood. Early maternal separation (EMS) is a stressful event that also alters neurodevelopment and adolescent and adult behaviors. The aim of the present study is to analyze the interaction between the effects of the neonatal alteration of allopregnanolone (AlloP), neurosteroid that increase its levels after acute stress presentation, and EMS on adolescent exploration and adult anxiety and sensorimotor gating in male rats. AlloP (10mg/kgs.c.) was administrated between postnatal day 5 (PN5) and PN9, and a single 24-hour period of EMS was carried out on PN9. Exploration was analyzed at PN40 and PN60. At adult age (PN85), anxiety was tested by means of the elevated plus-maze test (EPM), and sensorimotor gating by means of prepulse inhibition test (PPI). PPI deterioration has been considered as a reliable indicator of diseases such as schizophrenia. Results showed that the previous neonatal AlloP administration neutralized the effects of EMS in the adolescent exploration (increase of traveled distance and decrease of head-dips). In adult age, an anxiolytic-like profile was observed as a consequence of EMS. Finally, EMS and neonatal AlloP disrupted PPI. Taken together, these data show the important role that physiological neonatal AlloP levels and stressful events play in neural development, adult behavior and vulnerability to neurodevelopmental disorders such as schizophrenia.
► Early maternal separation (EMS) induces anxiogenic-like profile in the adolescence. ► Neonatal AlloP administration prevents anxiogenic effects of EMS in the adolescence. ► Early maternal separation (EMS) induces anxiolytic-like profile in the adult age. ► EMS and neonatal AlloP administration deteriorate prepulse inhibition in adulthood. ► Neonatal AlloP levels and stress can determine vulnerability to emotional disorders.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>23410958</pmid><doi>10.1016/j.yhbeh.2013.02.002</doi><tpages>9</tpages></addata></record> |
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| subjects | Aging - physiology Allopregnanolone Animal behavior Animals Animals, Newborn Anxiety Anxiety - psychology Anxiety, Separation - psychology Behavioral psychophysiology Biological and medical sciences Body Weight - drug effects Early maternal separation Exploratory Behavior - drug effects Fundamental and applied biological sciences. Psychology Gonadal Steroid Hormones - pharmacology Hormones and behavior Male Maternal Deprivation Neurodevelopment Neurosteroids Novelty exploration Pregnanolone - pharmacology Prepulse inhibition Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Reflex, Startle - drug effects Rodents Steroids Stress |
| title | Interaction between neonatal allopregnanolone administration and early maternal separation: Effects on adolescent and adult behaviors in male rat |
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