Idiopathic hand osteoarthritis vs haemochromatosis arthropathy--a clinical, functional and radiographic study
Haemochromatosis arthropathy is a secondary OA and the most frequent and earliest clinical presentation of hereditary haemochromatosis (HH). The aim of this study was to perform a direct clinical, functional and radiographic comparison with idiopathic hand OA (HOA) to unravel important differences b...
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| Veröffentlicht in: | Rheumatology (Oxford, England) England), 2013-05, Vol.52 (5), p.910-915 |
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| container_title | Rheumatology (Oxford, England) |
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| creator | Dallos, Tomás Sahinbegovic, Enijad Stamm, Tanja Aigner, Elmar Axmann, Roland Stadlmayr, Andreas Englbrecht, Matthias Datz, Christian Schett, Georg Zwerina, Jochen |
| description | Haemochromatosis arthropathy is a secondary OA and the most frequent and earliest clinical presentation of hereditary haemochromatosis (HH). The aim of this study was to perform a direct clinical, functional and radiographic comparison with idiopathic hand OA (HOA) to unravel important differences between these clinical entities.
In total, 299 patients (141 with HH arthropathy of the hands and 158 patients with idiopathic HOA) were recruited. Structured clinical assessment including hand function tests, as well as hand radiographs with scoring according to Kellgren-Lawrence, were carried out in all patients.
HH arthropathy and HOA differed significantly: patients with HH arthropathy were younger and predominantly male as compared with HOA. In males but not females, HH arthropathy led to an earlier start of symptoms than in HOA. Patients with HOA had more tender joints and worse hand function than patients with HH arthropathy, although subjective measures of joint pain and function were similar. MCP and wrist joint involvement was more frequent and severe in HH arthropathy, while HOA patients more frequently had degenerative changes in the first CMC as well as PIP and DIP joints.
HH arthropathy and idiopathic HOA differ significantly in terms of epidemiology, localization, severity of symptoms and radiographic changes. |
| doi_str_mv | 10.1093/rheumatology/kes392 |
| format | Article |
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In total, 299 patients (141 with HH arthropathy of the hands and 158 patients with idiopathic HOA) were recruited. Structured clinical assessment including hand function tests, as well as hand radiographs with scoring according to Kellgren-Lawrence, were carried out in all patients.
HH arthropathy and HOA differed significantly: patients with HH arthropathy were younger and predominantly male as compared with HOA. In males but not females, HH arthropathy led to an earlier start of symptoms than in HOA. Patients with HOA had more tender joints and worse hand function than patients with HH arthropathy, although subjective measures of joint pain and function were similar. MCP and wrist joint involvement was more frequent and severe in HH arthropathy, while HOA patients more frequently had degenerative changes in the first CMC as well as PIP and DIP joints.
HH arthropathy and idiopathic HOA differ significantly in terms of epidemiology, localization, severity of symptoms and radiographic changes.</description><identifier>ISSN: 1462-0324</identifier><identifier>EISSN: 1462-0332</identifier><identifier>DOI: 10.1093/rheumatology/kes392</identifier><identifier>PMID: 23315789</identifier><language>eng</language><publisher>England</publisher><subject>Aged ; Arthralgia - diagnostic imaging ; Arthralgia - physiopathology ; Cohort Studies ; Cross-Sectional Studies ; Female ; Hand Joints - diagnostic imaging ; Hand Joints - physiopathology ; Hemochromatosis - diagnostic imaging ; Hemochromatosis - epidemiology ; Hemochromatosis - physiopathology ; Humans ; Incidence ; Male ; Middle Aged ; Osteoarthritis - diagnostic imaging ; Osteoarthritis - epidemiology ; Osteoarthritis - physiopathology ; Pain Measurement ; Prognosis ; Prospective Studies ; Radiography ; Range of Motion, Articular - physiology ; Risk Assessment ; Severity of Illness Index</subject><ispartof>Rheumatology (Oxford, England), 2013-05, Vol.52 (5), p.910-915</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-d1b01f166f738ee7813c6888f87052bdaabea4e204fc5d5b18b2efbf19707bde3</citedby><cites>FETCH-LOGICAL-c383t-d1b01f166f738ee7813c6888f87052bdaabea4e204fc5d5b18b2efbf19707bde3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23315789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dallos, Tomás</creatorcontrib><creatorcontrib>Sahinbegovic, Enijad</creatorcontrib><creatorcontrib>Stamm, Tanja</creatorcontrib><creatorcontrib>Aigner, Elmar</creatorcontrib><creatorcontrib>Axmann, Roland</creatorcontrib><creatorcontrib>Stadlmayr, Andreas</creatorcontrib><creatorcontrib>Englbrecht, Matthias</creatorcontrib><creatorcontrib>Datz, Christian</creatorcontrib><creatorcontrib>Schett, Georg</creatorcontrib><creatorcontrib>Zwerina, Jochen</creatorcontrib><title>Idiopathic hand osteoarthritis vs haemochromatosis arthropathy--a clinical, functional and radiographic study</title><title>Rheumatology (Oxford, England)</title><addtitle>Rheumatology (Oxford)</addtitle><description>Haemochromatosis arthropathy is a secondary OA and the most frequent and earliest clinical presentation of hereditary haemochromatosis (HH). The aim of this study was to perform a direct clinical, functional and radiographic comparison with idiopathic hand OA (HOA) to unravel important differences between these clinical entities.
In total, 299 patients (141 with HH arthropathy of the hands and 158 patients with idiopathic HOA) were recruited. Structured clinical assessment including hand function tests, as well as hand radiographs with scoring according to Kellgren-Lawrence, were carried out in all patients.
HH arthropathy and HOA differed significantly: patients with HH arthropathy were younger and predominantly male as compared with HOA. In males but not females, HH arthropathy led to an earlier start of symptoms than in HOA. Patients with HOA had more tender joints and worse hand function than patients with HH arthropathy, although subjective measures of joint pain and function were similar. MCP and wrist joint involvement was more frequent and severe in HH arthropathy, while HOA patients more frequently had degenerative changes in the first CMC as well as PIP and DIP joints.
HH arthropathy and idiopathic HOA differ significantly in terms of epidemiology, localization, severity of symptoms and radiographic changes.</description><subject>Aged</subject><subject>Arthralgia - diagnostic imaging</subject><subject>Arthralgia - physiopathology</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Hand Joints - diagnostic imaging</subject><subject>Hand Joints - physiopathology</subject><subject>Hemochromatosis - diagnostic imaging</subject><subject>Hemochromatosis - epidemiology</subject><subject>Hemochromatosis - physiopathology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Osteoarthritis - diagnostic imaging</subject><subject>Osteoarthritis - epidemiology</subject><subject>Osteoarthritis - physiopathology</subject><subject>Pain Measurement</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Radiography</subject><subject>Range of Motion, Articular - physiology</subject><subject>Risk Assessment</subject><subject>Severity of Illness Index</subject><issn>1462-0324</issn><issn>1462-0332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUctKw0AUHUSxtfoFgmTpwth55DFZSvFRKLjRdZhnM5pk4sxEyN-btLW4dHUv557HhQPANYL3CBZk6SrVNyzY2m6H5afypMAnYI6SDMeQEHx63HEyAxfef0AIU0ToOZhhQlCa02IOmrU0tmOhMiKqWCsj64OyzIXKmWB89O1HWDVWVM5OYX7EdtedaIhjFonatEaw-i7SfSuCsS2ro8nKsdF761g3mfvQy-ESnGlWe3V1mAvw_vT4tnqJN6_P69XDJhaEkhBLxCHSKMt0TqhSOUVEZJRSTXOYYi4Z44olCsNEi1SmHFGOleYaFTnMuVRkAW73vp2zX73yoWyMF6quWats70tEUoxpVlD8D-r4UlEQlI9UsqcKZ713SpedMw1zQ4lgOVVS_q2k3Fcyqm4OAT1vlDxqfjsgP3GEj5E</recordid><startdate>201305</startdate><enddate>201305</enddate><creator>Dallos, Tomás</creator><creator>Sahinbegovic, Enijad</creator><creator>Stamm, Tanja</creator><creator>Aigner, Elmar</creator><creator>Axmann, Roland</creator><creator>Stadlmayr, Andreas</creator><creator>Englbrecht, Matthias</creator><creator>Datz, Christian</creator><creator>Schett, Georg</creator><creator>Zwerina, Jochen</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>201305</creationdate><title>Idiopathic hand osteoarthritis vs haemochromatosis arthropathy--a clinical, functional and radiographic study</title><author>Dallos, Tomás ; Sahinbegovic, Enijad ; Stamm, Tanja ; Aigner, Elmar ; Axmann, Roland ; Stadlmayr, Andreas ; Englbrecht, Matthias ; Datz, Christian ; Schett, Georg ; Zwerina, Jochen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-d1b01f166f738ee7813c6888f87052bdaabea4e204fc5d5b18b2efbf19707bde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Arthralgia - diagnostic imaging</topic><topic>Arthralgia - physiopathology</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Hand Joints - diagnostic imaging</topic><topic>Hand Joints - physiopathology</topic><topic>Hemochromatosis - diagnostic imaging</topic><topic>Hemochromatosis - epidemiology</topic><topic>Hemochromatosis - physiopathology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Osteoarthritis - diagnostic imaging</topic><topic>Osteoarthritis - epidemiology</topic><topic>Osteoarthritis - physiopathology</topic><topic>Pain Measurement</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Radiography</topic><topic>Range of Motion, Articular - physiology</topic><topic>Risk Assessment</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dallos, Tomás</creatorcontrib><creatorcontrib>Sahinbegovic, Enijad</creatorcontrib><creatorcontrib>Stamm, Tanja</creatorcontrib><creatorcontrib>Aigner, Elmar</creatorcontrib><creatorcontrib>Axmann, Roland</creatorcontrib><creatorcontrib>Stadlmayr, Andreas</creatorcontrib><creatorcontrib>Englbrecht, Matthias</creatorcontrib><creatorcontrib>Datz, Christian</creatorcontrib><creatorcontrib>Schett, Georg</creatorcontrib><creatorcontrib>Zwerina, Jochen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Rheumatology (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dallos, Tomás</au><au>Sahinbegovic, Enijad</au><au>Stamm, Tanja</au><au>Aigner, Elmar</au><au>Axmann, Roland</au><au>Stadlmayr, Andreas</au><au>Englbrecht, Matthias</au><au>Datz, Christian</au><au>Schett, Georg</au><au>Zwerina, Jochen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Idiopathic hand osteoarthritis vs haemochromatosis arthropathy--a clinical, functional and radiographic study</atitle><jtitle>Rheumatology (Oxford, England)</jtitle><addtitle>Rheumatology (Oxford)</addtitle><date>2013-05</date><risdate>2013</risdate><volume>52</volume><issue>5</issue><spage>910</spage><epage>915</epage><pages>910-915</pages><issn>1462-0324</issn><eissn>1462-0332</eissn><abstract>Haemochromatosis arthropathy is a secondary OA and the most frequent and earliest clinical presentation of hereditary haemochromatosis (HH). The aim of this study was to perform a direct clinical, functional and radiographic comparison with idiopathic hand OA (HOA) to unravel important differences between these clinical entities.
In total, 299 patients (141 with HH arthropathy of the hands and 158 patients with idiopathic HOA) were recruited. Structured clinical assessment including hand function tests, as well as hand radiographs with scoring according to Kellgren-Lawrence, were carried out in all patients.
HH arthropathy and HOA differed significantly: patients with HH arthropathy were younger and predominantly male as compared with HOA. In males but not females, HH arthropathy led to an earlier start of symptoms than in HOA. Patients with HOA had more tender joints and worse hand function than patients with HH arthropathy, although subjective measures of joint pain and function were similar. MCP and wrist joint involvement was more frequent and severe in HH arthropathy, while HOA patients more frequently had degenerative changes in the first CMC as well as PIP and DIP joints.
HH arthropathy and idiopathic HOA differ significantly in terms of epidemiology, localization, severity of symptoms and radiographic changes.</abstract><cop>England</cop><pmid>23315789</pmid><doi>10.1093/rheumatology/kes392</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Aged Arthralgia - diagnostic imaging Arthralgia - physiopathology Cohort Studies Cross-Sectional Studies Female Hand Joints - diagnostic imaging Hand Joints - physiopathology Hemochromatosis - diagnostic imaging Hemochromatosis - epidemiology Hemochromatosis - physiopathology Humans Incidence Male Middle Aged Osteoarthritis - diagnostic imaging Osteoarthritis - epidemiology Osteoarthritis - physiopathology Pain Measurement Prognosis Prospective Studies Radiography Range of Motion, Articular - physiology Risk Assessment Severity of Illness Index |
| title | Idiopathic hand osteoarthritis vs haemochromatosis arthropathy--a clinical, functional and radiographic study |
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