Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

T cell activation triggers proliferation and effector-cell differentiation. Cantrell and colleagues show that TCR signaling induces upregulation of amino-acid transporters necessary for metabolic reprogramming via the kinase complex mTORC1 and transcription factor c-Myc. T lymphocytes must regulate...

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Veröffentlicht in:	Nature immunology 2013-05, Vol.14 (5), p.500-508
Hauptverfasser:	Sinclair, Linda V, Rolf, Julia, Emslie, Elizabeth, Shi, Yun-Bo, Taylor, Peter M, Cantrell, Doreen A
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554 631/250/1619/554/1834/1269 631/250/2152/1566/1618 631/250/2152/1566/2493 631/250/516 631/80/313 Amino acids Amino Acids, Neutral - metabolism Animals Biomedicine Cell differentiation Cell Differentiation - genetics Cell Proliferation Cellular signal transduction Cytotoxicity, Immunologic Genetic aspects Immune response Immunology Infectious Diseases Interferon-gamma - metabolism Interleukin-2 - metabolism Large Neutral Amino Acid-Transporter 1 - genetics Large Neutral Amino Acid-Transporter 1 - metabolism Lymphocytes Mice Mice, Inbred C57BL Mice, Mutant Strains Nutrient uptake Pathogens Physiological aspects Protein Transport Receptors, Antigen, T-Cell, alpha-beta - metabolism T cells T-Lymphocytes, Cytotoxic - immunology Up-Regulation
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