Nuclear import of LASP-1 is regulated by phosphorylation and dynamic protein–protein interactions

LASP-1 is a multidomain protein predominantly localized at focal contacts, where it regulates cytoskeleton dynamics and cell migration. However, in different tumor entities, a nuclear LASP-1 accumulation is observed, thought to have an important role in cancer progression. Until now, the molecular m...

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Veröffentlicht in:	Oncogene 2013-04, Vol.32 (16), p.2107-2113
Hauptverfasser:	Mihlan, S, Reiß, C, Thalheimer, P, Herterich, S, Gaetzner, S, Kremerskothen, J, Pavenstädt, H J, Lewandrowski, U, Sickmann, A, Butt, E
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/389 631/80/86 Active Transport, Cell Nucleus Adaptor Proteins, Signal Transducing - biosynthesis Adaptor Proteins, Signal Transducing - metabolism Apoptosis Breast Neoplasms - metabolism Calcineurin Cancer Cell Biology Cell Line, Tumor Cell migration Cell Nucleus - metabolism Cellular proteins Cyclic AMP-Dependent Protein Kinases - metabolism Cytoplasm Cytoskeletal Proteins - biosynthesis Cytoskeletal Proteins - metabolism Cytoskeleton Dephosphorylation Development and progression Human Genetics Humans Internal Medicine LIM Domain Proteins - biosynthesis LIM Domain Proteins - metabolism Medicine Medicine & Public Health Molecular modelling Nuclear transport Oncology original-article Phosphorylation Physiological aspects Proline Protein Binding Protein interaction Protein Structure, Tertiary Protein-protein interactions Proteins Signal Transduction Tumors Zonula Occludens-2 Protein - metabolism
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