Prevalence and characteristics of depression in mild cognitive impairment: the Sydney Memory and Ageing Study
Shahnawaz Z, Reppermund S, Brodaty H, Crawford JD, Draper B, Trollor JN, Sachdev PS. Prevalence and characteristics of depression in mild cognitive impairment: the Sydney memory and ageing study. Objective: Depression might be a risk factor for dementia. However, little is known about the prevalenc...
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| Veröffentlicht in: | Acta psychiatrica Scandinavica 2013-05, Vol.127 (5), p.394-402 |
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| container_title | Acta psychiatrica Scandinavica |
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| creator | Shahnawaz, Z. Reppermund, S. Brodaty, H. Crawford, J. D. Draper, B. Trollor, J. N. Sachdev, P. S. |
| description | Shahnawaz Z, Reppermund S, Brodaty H, Crawford JD, Draper B, Trollor JN, Sachdev PS. Prevalence and characteristics of depression in mild cognitive impairment: the Sydney memory and ageing study.
Objective: Depression might be a risk factor for dementia. However, little is known about the prevalence of depressive symptoms in mild cognitive impairment (MCI) and whether mood or motivation‐related symptoms are predominant.
Method: A total of 767 non‐demented community‐dwelling adults aged 70–90 years completed a comprehensive assessment, including neuropsychological testing, and a past psychiatric/medical history interview. Depressive symptoms were assessed using the Geriatric Depression Scale (GDS) and Kessler Psychological Distress Scale (K10). Exploratory factor analysis was performed on the GDS and K10 to derive ‘mood’ and ‘motivation’ subscales.
Results: A total of 290 participants were classified as having MCI and 468 as cognitively normal (CN). Participants with MCI reported more depressive symptoms, and more MCI participants met the cut‐off for clinically significant symptoms, relative to CN participants. Those with amnestic MCI (aMCI), but not non‐amnestic MCI, had more depressive symptoms and were more likely to meet the cut‐off for clinically significant depressive symptoms, relative to CN participants. Participants with MCI reported more mood‐related symptoms than CN participants, while there were no differences between groups on motivation‐related symptoms.
Conclusion: Individuals with MCI, especially aMCI, endorse more depressive symptoms when compared with cognitively intact individuals. These findings highlight the importance of assessing and treating depressive symptoms in MCI. |
| doi_str_mv | 10.1111/acps.12008 |
| format | Article |
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Objective: Depression might be a risk factor for dementia. However, little is known about the prevalence of depressive symptoms in mild cognitive impairment (MCI) and whether mood or motivation‐related symptoms are predominant.
Method: A total of 767 non‐demented community‐dwelling adults aged 70–90 years completed a comprehensive assessment, including neuropsychological testing, and a past psychiatric/medical history interview. Depressive symptoms were assessed using the Geriatric Depression Scale (GDS) and Kessler Psychological Distress Scale (K10). Exploratory factor analysis was performed on the GDS and K10 to derive ‘mood’ and ‘motivation’ subscales.
Results: A total of 290 participants were classified as having MCI and 468 as cognitively normal (CN). Participants with MCI reported more depressive symptoms, and more MCI participants met the cut‐off for clinically significant symptoms, relative to CN participants. Those with amnestic MCI (aMCI), but not non‐amnestic MCI, had more depressive symptoms and were more likely to meet the cut‐off for clinically significant depressive symptoms, relative to CN participants. Participants with MCI reported more mood‐related symptoms than CN participants, while there were no differences between groups on motivation‐related symptoms.
Conclusion: Individuals with MCI, especially aMCI, endorse more depressive symptoms when compared with cognitively intact individuals. These findings highlight the importance of assessing and treating depressive symptoms in MCI.</description><identifier>ISSN: 0001-690X</identifier><identifier>EISSN: 1600-0447</identifier><identifier>DOI: 10.1111/acps.12008</identifier><identifier>PMID: 22943523</identifier><identifier>CODEN: APYSA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult and adolescent clinical studies ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Cognitive Dysfunction - complications ; Cognitive Dysfunction - epidemiology ; Cognitive Dysfunction - psychology ; Cross-Sectional Studies ; Dementia ; Depression ; Depression - complications ; Depression - epidemiology ; Depression - psychology ; depression, mild cognitive impairment ; depressive symptoms ; Factor Analysis, Statistical ; Female ; Geriatric Assessment ; Geriatric Depression Scale ; Geriatrics ; Humans ; Kessler Psychological Distress Scale ; Male ; Medical sciences ; Mental depression ; mild cognitive impairment ; Miscellaneous ; Mood disorders ; Neuropsychological Tests ; Neuropsychology ; New South Wales - epidemiology ; Older people ; Prevalence ; Psychiatric Status Rating Scales ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Risk Factors</subject><ispartof>Acta psychiatrica Scandinavica, 2013-05, Vol.127 (5), p.394-402</ispartof><rights>2012 John Wiley & Sons A/S</rights><rights>2015 INIST-CNRS</rights><rights>2012 John Wiley & Sons A/S.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4588-f672ef6990a18788c6d3f5cca0700897d1c636151a7fc1812cb2486b34c7d6c73</citedby><cites>FETCH-LOGICAL-c4588-f672ef6990a18788c6d3f5cca0700897d1c636151a7fc1812cb2486b34c7d6c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Facps.12008$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Facps.12008$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27242821$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22943523$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shahnawaz, Z.</creatorcontrib><creatorcontrib>Reppermund, S.</creatorcontrib><creatorcontrib>Brodaty, H.</creatorcontrib><creatorcontrib>Crawford, J. D.</creatorcontrib><creatorcontrib>Draper, B.</creatorcontrib><creatorcontrib>Trollor, J. N.</creatorcontrib><creatorcontrib>Sachdev, P. S.</creatorcontrib><title>Prevalence and characteristics of depression in mild cognitive impairment: the Sydney Memory and Ageing Study</title><title>Acta psychiatrica Scandinavica</title><addtitle>Acta Psychiatr Scand</addtitle><description>Shahnawaz Z, Reppermund S, Brodaty H, Crawford JD, Draper B, Trollor JN, Sachdev PS. Prevalence and characteristics of depression in mild cognitive impairment: the Sydney memory and ageing study.
Objective: Depression might be a risk factor for dementia. However, little is known about the prevalence of depressive symptoms in mild cognitive impairment (MCI) and whether mood or motivation‐related symptoms are predominant.
Method: A total of 767 non‐demented community‐dwelling adults aged 70–90 years completed a comprehensive assessment, including neuropsychological testing, and a past psychiatric/medical history interview. Depressive symptoms were assessed using the Geriatric Depression Scale (GDS) and Kessler Psychological Distress Scale (K10). Exploratory factor analysis was performed on the GDS and K10 to derive ‘mood’ and ‘motivation’ subscales.
Results: A total of 290 participants were classified as having MCI and 468 as cognitively normal (CN). Participants with MCI reported more depressive symptoms, and more MCI participants met the cut‐off for clinically significant symptoms, relative to CN participants. Those with amnestic MCI (aMCI), but not non‐amnestic MCI, had more depressive symptoms and were more likely to meet the cut‐off for clinically significant depressive symptoms, relative to CN participants. Participants with MCI reported more mood‐related symptoms than CN participants, while there were no differences between groups on motivation‐related symptoms.
Conclusion: Individuals with MCI, especially aMCI, endorse more depressive symptoms when compared with cognitively intact individuals. These findings highlight the importance of assessing and treating depressive symptoms in MCI.</description><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Cognitive Dysfunction - complications</subject><subject>Cognitive Dysfunction - epidemiology</subject><subject>Cognitive Dysfunction - psychology</subject><subject>Cross-Sectional Studies</subject><subject>Dementia</subject><subject>Depression</subject><subject>Depression - complications</subject><subject>Depression - epidemiology</subject><subject>Depression - psychology</subject><subject>depression, mild cognitive impairment</subject><subject>depressive symptoms</subject><subject>Factor Analysis, Statistical</subject><subject>Female</subject><subject>Geriatric Assessment</subject><subject>Geriatric Depression Scale</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Kessler Psychological Distress Scale</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental depression</subject><subject>mild cognitive impairment</subject><subject>Miscellaneous</subject><subject>Mood disorders</subject><subject>Neuropsychological Tests</subject><subject>Neuropsychology</subject><subject>New South Wales - epidemiology</subject><subject>Older people</subject><subject>Prevalence</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Risk Factors</subject><issn>0001-690X</issn><issn>1600-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0V1rFDEUBuAgit1Wb_wBEhChCFPzNUnGu2XRVqhaXMXehWzmzDZ1JjMms9X592a72wpeiLkJgeecnMOL0DNKTmg-r60b0gllhOgHaEYlIQURQj1EM0IILWRFLg_QYUrX-VlSoh-jA8YqwUvGZ6i7iHBjWwgOsA01dlc2WjdC9Gn0LuG-wTUMEVLyfcA-4M63WfXr4Ed_A9h3g_WxgzC-weMV4OVUB5jwB-j6ON12nK_BhzVejpt6eoIeNbZN8HR_H6Gv795-WZwV559O3y_m54UTpdZFIxWDRlYVsVQrrZ2seVM6Z4nKS1aqpk5ySUtqVeOopsytmNByxYVTtXSKH6HjXd8h9j82kEbT-eSgbW2AfpMMzcszLQgT_0GZZkwqWWX64i963W9iyItslawYz8Nn9WqnXOxTitCYIfrOxslQYrZ5mW1e5javjJ_vW25WHdT39C6gDF7ugU3Otk20wfn0xykm8nw0O7pzP30L0z--NPPFxfLu82JXk7OGX_c1Nn43UnFVmm8fT408E-Izp6W55L8BOqy6oA</recordid><startdate>201305</startdate><enddate>201305</enddate><creator>Shahnawaz, Z.</creator><creator>Reppermund, S.</creator><creator>Brodaty, H.</creator><creator>Crawford, J. D.</creator><creator>Draper, B.</creator><creator>Trollor, J. N.</creator><creator>Sachdev, P. S.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201305</creationdate><title>Prevalence and characteristics of depression in mild cognitive impairment: the Sydney Memory and Ageing Study</title><author>Shahnawaz, Z. ; Reppermund, S. ; Brodaty, H. ; Crawford, J. D. ; Draper, B. ; Trollor, J. N. ; Sachdev, P. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4588-f672ef6990a18788c6d3f5cca0700897d1c636151a7fc1812cb2486b34c7d6c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Cognitive Dysfunction - complications</topic><topic>Cognitive Dysfunction - epidemiology</topic><topic>Cognitive Dysfunction - psychology</topic><topic>Cross-Sectional Studies</topic><topic>Dementia</topic><topic>Depression</topic><topic>Depression - complications</topic><topic>Depression - epidemiology</topic><topic>Depression - psychology</topic><topic>depression, mild cognitive impairment</topic><topic>depressive symptoms</topic><topic>Factor Analysis, Statistical</topic><topic>Female</topic><topic>Geriatric Assessment</topic><topic>Geriatric Depression Scale</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Kessler Psychological Distress Scale</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental depression</topic><topic>mild cognitive impairment</topic><topic>Miscellaneous</topic><topic>Mood disorders</topic><topic>Neuropsychological Tests</topic><topic>Neuropsychology</topic><topic>New South Wales - epidemiology</topic><topic>Older people</topic><topic>Prevalence</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shahnawaz, Z.</creatorcontrib><creatorcontrib>Reppermund, S.</creatorcontrib><creatorcontrib>Brodaty, H.</creatorcontrib><creatorcontrib>Crawford, J. D.</creatorcontrib><creatorcontrib>Draper, B.</creatorcontrib><creatorcontrib>Trollor, J. N.</creatorcontrib><creatorcontrib>Sachdev, P. S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Acta psychiatrica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shahnawaz, Z.</au><au>Reppermund, S.</au><au>Brodaty, H.</au><au>Crawford, J. D.</au><au>Draper, B.</au><au>Trollor, J. N.</au><au>Sachdev, P. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and characteristics of depression in mild cognitive impairment: the Sydney Memory and Ageing Study</atitle><jtitle>Acta psychiatrica Scandinavica</jtitle><addtitle>Acta Psychiatr Scand</addtitle><date>2013-05</date><risdate>2013</risdate><volume>127</volume><issue>5</issue><spage>394</spage><epage>402</epage><pages>394-402</pages><issn>0001-690X</issn><eissn>1600-0447</eissn><coden>APYSA9</coden><abstract>Shahnawaz Z, Reppermund S, Brodaty H, Crawford JD, Draper B, Trollor JN, Sachdev PS. Prevalence and characteristics of depression in mild cognitive impairment: the Sydney memory and ageing study.
Objective: Depression might be a risk factor for dementia. However, little is known about the prevalence of depressive symptoms in mild cognitive impairment (MCI) and whether mood or motivation‐related symptoms are predominant.
Method: A total of 767 non‐demented community‐dwelling adults aged 70–90 years completed a comprehensive assessment, including neuropsychological testing, and a past psychiatric/medical history interview. Depressive symptoms were assessed using the Geriatric Depression Scale (GDS) and Kessler Psychological Distress Scale (K10). Exploratory factor analysis was performed on the GDS and K10 to derive ‘mood’ and ‘motivation’ subscales.
Results: A total of 290 participants were classified as having MCI and 468 as cognitively normal (CN). Participants with MCI reported more depressive symptoms, and more MCI participants met the cut‐off for clinically significant symptoms, relative to CN participants. Those with amnestic MCI (aMCI), but not non‐amnestic MCI, had more depressive symptoms and were more likely to meet the cut‐off for clinically significant depressive symptoms, relative to CN participants. Participants with MCI reported more mood‐related symptoms than CN participants, while there were no differences between groups on motivation‐related symptoms.
Conclusion: Individuals with MCI, especially aMCI, endorse more depressive symptoms when compared with cognitively intact individuals. These findings highlight the importance of assessing and treating depressive symptoms in MCI.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22943523</pmid><doi>10.1111/acps.12008</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult and adolescent clinical studies Aged Aged, 80 and over Biological and medical sciences Cognitive Dysfunction - complications Cognitive Dysfunction - epidemiology Cognitive Dysfunction - psychology Cross-Sectional Studies Dementia Depression Depression - complications Depression - epidemiology Depression - psychology depression, mild cognitive impairment depressive symptoms Factor Analysis, Statistical Female Geriatric Assessment Geriatric Depression Scale Geriatrics Humans Kessler Psychological Distress Scale Male Medical sciences Mental depression mild cognitive impairment Miscellaneous Mood disorders Neuropsychological Tests Neuropsychology New South Wales - epidemiology Older people Prevalence Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Risk Factors |
| title | Prevalence and characteristics of depression in mild cognitive impairment: the Sydney Memory and Ageing Study |
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