Genetic characterization of tigecycline resistance in clinical isolates of Enterobacter cloacae and Enterobacter aerogenes

The intrinsically encoded ramA gene has been linked to tigecycline resistance through the up-regulation of efflux pump AcrAB in Enterobacter cloacae. The molecular basis for increased ramA expression in E. cloacae and Enterobacter aerogenes, as well as the role of AraC regulator rarA, has not yet be...

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Veröffentlicht in:Journal of antimicrobial chemotherapy 2013-05, Vol.68 (5), p.1011-1018
Hauptverfasser: Veleba, Mark, De Majumdar, Shyamasree, Hornsey, Michael, Woodford, Neil, Schneiders, Thamarai
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Sprache:eng
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