Transport Function and Transcriptional Regulation of a Liver-Enriched Human Organic Anion Transporting Polypeptide 2B1 Transcriptional Start Site Variant

Human organic anion transporting polypeptide 2B1 (OATP2B1) is a membrane transporter that facilitates the cellular uptake of a number of endogenous compounds and drugs. OATP2B1 is widely expressed in tissues including the small intestine, liver, kidney, placenta, heart, skeletal muscle, and platelet...

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Veröffentlicht in:	Molecular pharmacology 2013-06, Vol.83 (6), p.1218-1228
Hauptverfasser:	Knauer, Michael J., Girdwood, Anthea J., Kim, Richard B., Tirona, Rommel G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Transport Cell Line, Tumor Gene Knockdown Techniques Genes, Reporter Hepatocyte Nuclear Factor 4 - genetics Hepatocyte Nuclear Factor 4 - metabolism Humans Liver - metabolism Luciferases, Renilla - genetics Mutation Organ Specificity Organic Anion Transporters - genetics Organic Anion Transporters - metabolism Promoter Regions, Genetic Protein Binding Sequence Deletion Transcription Initiation Site Transcription, Genetic
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