Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1

Pediatric low-grade gliomas (PLGGs) are among the most common solid tumors in children but, apart from BRAF kinase mutations or duplications in specific subclasses, few genetic driver events are known. Diffuse PLGGs comprise a set of uncommon subtypes that exhibit invasive growth and are therefore e...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-05, Vol.110 (20), p.8188-8193
Hauptverfasser:	Ramkissoon, Lori A., Horowitz, Peleg M., Craig, Justin M., Ramkissoon, Shakti H., Rich, Benjamin E., Schumacher, Steven E., McKenna, Aaron, Lawrence, Michael S., Bergthold, Guillaume, Brastianos, Priscilla K., Tabak, Barbara, Ducar, Matthew D., Van Hummelen, Paul, MacConaill, Laura E., Pouissant-Young, Tina, Cho, Yoon-Jae, Taha, Hala, Mahmoud, Madeha, Bowers, Daniel C., Margraf, Linda, Tabori, Uri, Hawkins, Cynthia, Packer, Roger J., Hill, D. Ashley, Pomeroy, Scott L., Eberhart, Charles G., Dunn, Ian F., Goumnerova, Liliana, Getz, Gad, Chan, Jennifer A., Santagata, Sandro, Hahn, William C., Stiles, Charles D., Ligon, Azra H., Kieran, Mark W., Beroukhim, Rameen, Ligon, Keith L.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells adults Alleles Animals Astrocytoma Biological Sciences birds Brain Neoplasms - genetics Brain Neoplasms - pathology Cancer Cell growth Cell Line, Tumor Child Child, Preschool children Cohort Studies Comparative Genomic Hybridization Gene expression Genetic mutation Genomes Genomics Glioma Glioma - genetics Glioma - pathology Humans Male Mice Mice, Nude Molecular biology Multigene Family Mutation neoplasm cells neoplasms oncogenes Pediatrics Protein Structure, Tertiary Proto-Oncogene Proteins - genetics Rodents sequence analysis Sequence Analysis, DNA Sequencing Trans-Activators - genetics Transcription factors Tumors
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