Influence of age and gender on autonomic regulation of heart
Heart rate variability (HRV) is a non-invasive method to measure cardiac autonomic function. Impairments in HRV have been proposed as independent risk factor for increased cardiac mortality and morbidity. Cardio protective phenomenon in females has been hypothesized to be due to differential autonom...
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| Veröffentlicht in: | Journal of clinical monitoring and computing 2013-06, Vol.27 (3), p.259-264 |
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| description | Heart rate variability (HRV) is a non-invasive method to measure cardiac autonomic function. Impairments in HRV have been proposed as independent risk factor for increased cardiac mortality and morbidity. Cardio protective phenomenon in females has been hypothesized to be due to differential autonomic tone. Age related loss of vagal control has been reported as predisposing factor for the development of cardiovascular disease. In this study we assessed effect of age and gender on autonomic regulation of heart in healthy volunteers. HRV data of 189 subjects (114 males and 75 females) were analyzed in time and frequency domains using customized program. Artifact free 5 min electrocardiogram segment was used for analysis. It was ensured that none of the subject had medical illness such as diabetes, hypertension, thyroid disorders, cardiac disorders, diseases potentially related with autonomic neuropathy and major psychiatric illness by careful history and clinical examination. HRV recordings were done under standard laboratory condition. On correlation analysis SDNN, RMSSD, total power negatively correlated with age suggesting reduced autonomic regulation of heart with increase in age (SDNN: r = −0.444,
p
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| doi_str_mv | 10.1007/s10877-012-9424-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1352280790</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1352280790</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-21e751b9685a30c975926f569c3cd485ca317c62e915deb0caf22d79a60ac1e73</originalsourceid><addsrcrecordid>eNp1kE1LxDAURYMojo7-ADdScOMmmo8macCNDH4MDLjRdcikr7VDm45Ju_Dfm6GjiOAqj7xzb8JB6IKSG0qIuo2UFEphQhnWOcsxP0AnVCiOmaT5YZp5oTDlRM3QaYwbQoguOD1GM8aZVkTnJ-hu6at2BO8g66vM1pBZX2Y1-BJC1vvMjkPv-65xWYB6bO3QpMtEvoMNwxk6qmwb4Xx_ztHb48Pr4hmvXp6Wi_sVdjkvBswoKEHXWhbCcuK0EprJSkjtuCvzQjjLqXKSgaaihDVxtmKsVNpKYl3K8jm6nnq3of8YIQ6ma6KDtrUe-jEaygVjBVGaJPTqD7rpx-DT73aULGSuOEsUnSgX-hgDVGYbms6GT0OJ2ak1k1qT1JqdWsNT5nLfPK47KH8S3y4TwCYgppWvIfx6-t_WLz5kgZw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1356864732</pqid></control><display><type>article</type><title>Influence of age and gender on autonomic regulation of heart</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Abhishekh, Hulegar A. ; Nisarga, Palgun ; Kisan, Ravikiran ; Meghana, Adoor ; Chandran, Sajish ; Trichur Raju ; Sathyaprabha, Talakad N.</creator><creatorcontrib>Abhishekh, Hulegar A. ; Nisarga, Palgun ; Kisan, Ravikiran ; Meghana, Adoor ; Chandran, Sajish ; Trichur Raju ; Sathyaprabha, Talakad N.</creatorcontrib><description>Heart rate variability (HRV) is a non-invasive method to measure cardiac autonomic function. Impairments in HRV have been proposed as independent risk factor for increased cardiac mortality and morbidity. Cardio protective phenomenon in females has been hypothesized to be due to differential autonomic tone. Age related loss of vagal control has been reported as predisposing factor for the development of cardiovascular disease. In this study we assessed effect of age and gender on autonomic regulation of heart in healthy volunteers. HRV data of 189 subjects (114 males and 75 females) were analyzed in time and frequency domains using customized program. Artifact free 5 min electrocardiogram segment was used for analysis. It was ensured that none of the subject had medical illness such as diabetes, hypertension, thyroid disorders, cardiac disorders, diseases potentially related with autonomic neuropathy and major psychiatric illness by careful history and clinical examination. HRV recordings were done under standard laboratory condition. On correlation analysis SDNN, RMSSD, total power negatively correlated with age suggesting reduced autonomic regulation of heart with increase in age (SDNN: r = −0.444,
p
< 0.01; RMSSD: r = −0.552,
p
< 0.01; total power: r = −0.474,
p
< 0.01); similarly High frequency power (HF.nu) negatively correlated with age (r = −0.167,
p
= 0.02), denoting loss of vagal tone with aging. LF/HF ratio correlated positively with age (r = 0.19,
p
< 0.01) suggesting a relative increase of sympathetic activity with increase in age. On multiple regression analysis to control for effect of age and heart rate while comparing males and females, LF.nu showed significant reduction suggesting lower sympathetic tone in females (β = −6.64;
p
< 0.01) and HF.nu showed increase at trend level (β = 4.47;
p
= 0.053). In conclusion, there is overall reduction in autonomic control of heart with increase in the age. Sympathetic tone predominates and vagal tone diminishes with aging process. Females showed greater vagal tone than male. This differential autonomic tone indicate age, gender related predisposition to cardiovascular disease.</description><identifier>ISSN: 1387-1307</identifier><identifier>EISSN: 1573-2614</identifier><identifier>DOI: 10.1007/s10877-012-9424-3</identifier><identifier>PMID: 23297094</identifier><identifier>CODEN: JCMCFG</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adolescent ; Adult ; Age Factors ; Aging - physiology ; Anesthesiology ; Autonomic Nervous System - physiology ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - physiopathology ; Critical Care Medicine ; Electrocardiography ; Female ; Health Sciences ; Heart Rate - physiology ; Humans ; Intensive ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Research ; Sex Characteristics ; Statistics for Life Sciences ; Sympathetic Nervous System - physiology ; Vagus Nerve - physiology ; Young Adult</subject><ispartof>Journal of clinical monitoring and computing, 2013-06, Vol.27 (3), p.259-264</ispartof><rights>Springer Science+Business Media New York 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-21e751b9685a30c975926f569c3cd485ca317c62e915deb0caf22d79a60ac1e73</citedby><cites>FETCH-LOGICAL-c438t-21e751b9685a30c975926f569c3cd485ca317c62e915deb0caf22d79a60ac1e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10877-012-9424-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10877-012-9424-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23297094$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abhishekh, Hulegar A.</creatorcontrib><creatorcontrib>Nisarga, Palgun</creatorcontrib><creatorcontrib>Kisan, Ravikiran</creatorcontrib><creatorcontrib>Meghana, Adoor</creatorcontrib><creatorcontrib>Chandran, Sajish</creatorcontrib><creatorcontrib>Trichur Raju</creatorcontrib><creatorcontrib>Sathyaprabha, Talakad N.</creatorcontrib><title>Influence of age and gender on autonomic regulation of heart</title><title>Journal of clinical monitoring and computing</title><addtitle>J Clin Monit Comput</addtitle><addtitle>J Clin Monit Comput</addtitle><description>Heart rate variability (HRV) is a non-invasive method to measure cardiac autonomic function. Impairments in HRV have been proposed as independent risk factor for increased cardiac mortality and morbidity. Cardio protective phenomenon in females has been hypothesized to be due to differential autonomic tone. Age related loss of vagal control has been reported as predisposing factor for the development of cardiovascular disease. In this study we assessed effect of age and gender on autonomic regulation of heart in healthy volunteers. HRV data of 189 subjects (114 males and 75 females) were analyzed in time and frequency domains using customized program. Artifact free 5 min electrocardiogram segment was used for analysis. It was ensured that none of the subject had medical illness such as diabetes, hypertension, thyroid disorders, cardiac disorders, diseases potentially related with autonomic neuropathy and major psychiatric illness by careful history and clinical examination. HRV recordings were done under standard laboratory condition. On correlation analysis SDNN, RMSSD, total power negatively correlated with age suggesting reduced autonomic regulation of heart with increase in age (SDNN: r = −0.444,
p
< 0.01; RMSSD: r = −0.552,
p
< 0.01; total power: r = −0.474,
p
< 0.01); similarly High frequency power (HF.nu) negatively correlated with age (r = −0.167,
p
= 0.02), denoting loss of vagal tone with aging. LF/HF ratio correlated positively with age (r = 0.19,
p
< 0.01) suggesting a relative increase of sympathetic activity with increase in age. On multiple regression analysis to control for effect of age and heart rate while comparing males and females, LF.nu showed significant reduction suggesting lower sympathetic tone in females (β = −6.64;
p
< 0.01) and HF.nu showed increase at trend level (β = 4.47;
p
= 0.053). In conclusion, there is overall reduction in autonomic control of heart with increase in the age. Sympathetic tone predominates and vagal tone diminishes with aging process. Females showed greater vagal tone than male. This differential autonomic tone indicate age, gender related predisposition to cardiovascular disease.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aging - physiology</subject><subject>Anesthesiology</subject><subject>Autonomic Nervous System - physiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Critical Care Medicine</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Health Sciences</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Intensive</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Research</subject><subject>Sex Characteristics</subject><subject>Statistics for Life Sciences</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Vagus Nerve - physiology</subject><subject>Young Adult</subject><issn>1387-1307</issn><issn>1573-2614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kE1LxDAURYMojo7-ADdScOMmmo8macCNDH4MDLjRdcikr7VDm45Ju_Dfm6GjiOAqj7xzb8JB6IKSG0qIuo2UFEphQhnWOcsxP0AnVCiOmaT5YZp5oTDlRM3QaYwbQoguOD1GM8aZVkTnJ-hu6at2BO8g66vM1pBZX2Y1-BJC1vvMjkPv-65xWYB6bO3QpMtEvoMNwxk6qmwb4Xx_ztHb48Pr4hmvXp6Wi_sVdjkvBswoKEHXWhbCcuK0EprJSkjtuCvzQjjLqXKSgaaihDVxtmKsVNpKYl3K8jm6nnq3of8YIQ6ma6KDtrUe-jEaygVjBVGaJPTqD7rpx-DT73aULGSuOEsUnSgX-hgDVGYbms6GT0OJ2ak1k1qT1JqdWsNT5nLfPK47KH8S3y4TwCYgppWvIfx6-t_WLz5kgZw</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Abhishekh, Hulegar A.</creator><creator>Nisarga, Palgun</creator><creator>Kisan, Ravikiran</creator><creator>Meghana, Adoor</creator><creator>Chandran, Sajish</creator><creator>Trichur Raju</creator><creator>Sathyaprabha, Talakad N.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7SC</scope><scope>7SP</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>JQ2</scope><scope>K7-</scope><scope>K9.</scope><scope>KB0</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20130601</creationdate><title>Influence of age and gender on autonomic regulation of heart</title><author>Abhishekh, Hulegar A. ; Nisarga, Palgun ; Kisan, Ravikiran ; Meghana, Adoor ; Chandran, Sajish ; Trichur Raju ; Sathyaprabha, Talakad N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-21e751b9685a30c975926f569c3cd485ca317c62e915deb0caf22d79a60ac1e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aging - physiology</topic><topic>Anesthesiology</topic><topic>Autonomic Nervous System - physiology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Critical Care Medicine</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Health Sciences</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Intensive</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Research</topic><topic>Sex Characteristics</topic><topic>Statistics for Life Sciences</topic><topic>Sympathetic Nervous System - physiology</topic><topic>Vagus Nerve - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abhishekh, Hulegar A.</creatorcontrib><creatorcontrib>Nisarga, Palgun</creatorcontrib><creatorcontrib>Kisan, Ravikiran</creatorcontrib><creatorcontrib>Meghana, Adoor</creatorcontrib><creatorcontrib>Chandran, Sajish</creatorcontrib><creatorcontrib>Trichur Raju</creatorcontrib><creatorcontrib>Sathyaprabha, Talakad N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Computer and Information Systems Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Computer Science Collection</collection><collection>Computer Science Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical monitoring and computing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abhishekh, Hulegar A.</au><au>Nisarga, Palgun</au><au>Kisan, Ravikiran</au><au>Meghana, Adoor</au><au>Chandran, Sajish</au><au>Trichur Raju</au><au>Sathyaprabha, Talakad N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of age and gender on autonomic regulation of heart</atitle><jtitle>Journal of clinical monitoring and computing</jtitle><stitle>J Clin Monit Comput</stitle><addtitle>J Clin Monit Comput</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>27</volume><issue>3</issue><spage>259</spage><epage>264</epage><pages>259-264</pages><issn>1387-1307</issn><eissn>1573-2614</eissn><coden>JCMCFG</coden><abstract>Heart rate variability (HRV) is a non-invasive method to measure cardiac autonomic function. Impairments in HRV have been proposed as independent risk factor for increased cardiac mortality and morbidity. Cardio protective phenomenon in females has been hypothesized to be due to differential autonomic tone. Age related loss of vagal control has been reported as predisposing factor for the development of cardiovascular disease. In this study we assessed effect of age and gender on autonomic regulation of heart in healthy volunteers. HRV data of 189 subjects (114 males and 75 females) were analyzed in time and frequency domains using customized program. Artifact free 5 min electrocardiogram segment was used for analysis. It was ensured that none of the subject had medical illness such as diabetes, hypertension, thyroid disorders, cardiac disorders, diseases potentially related with autonomic neuropathy and major psychiatric illness by careful history and clinical examination. HRV recordings were done under standard laboratory condition. On correlation analysis SDNN, RMSSD, total power negatively correlated with age suggesting reduced autonomic regulation of heart with increase in age (SDNN: r = −0.444,
p
< 0.01; RMSSD: r = −0.552,
p
< 0.01; total power: r = −0.474,
p
< 0.01); similarly High frequency power (HF.nu) negatively correlated with age (r = −0.167,
p
= 0.02), denoting loss of vagal tone with aging. LF/HF ratio correlated positively with age (r = 0.19,
p
< 0.01) suggesting a relative increase of sympathetic activity with increase in age. On multiple regression analysis to control for effect of age and heart rate while comparing males and females, LF.nu showed significant reduction suggesting lower sympathetic tone in females (β = −6.64;
p
< 0.01) and HF.nu showed increase at trend level (β = 4.47;
p
= 0.053). In conclusion, there is overall reduction in autonomic control of heart with increase in the age. Sympathetic tone predominates and vagal tone diminishes with aging process. Females showed greater vagal tone than male. This differential autonomic tone indicate age, gender related predisposition to cardiovascular disease.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>23297094</pmid><doi>10.1007/s10877-012-9424-3</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Age Factors Aging - physiology Anesthesiology Autonomic Nervous System - physiology Cardiovascular Diseases - etiology Cardiovascular Diseases - physiopathology Critical Care Medicine Electrocardiography Female Health Sciences Heart Rate - physiology Humans Intensive Male Medicine Medicine & Public Health Middle Aged Original Research Sex Characteristics Statistics for Life Sciences Sympathetic Nervous System - physiology Vagus Nerve - physiology Young Adult |
| title | Influence of age and gender on autonomic regulation of heart |
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