Epidermal Nerve Fibers Modulate Keratinocyte Growth via Neuropeptide Signaling in an Innervated Skin Model

Atopic eczema is a chronic inflammatory skin disease characterized by cutaneous nerve fiber sprouting and epidermal hyperplasia, pointing to an involvement of the peripheral nervous system in cutaneous homeostasis. However, the interaction of sensory neurons and skin cells is poorly understood. Usin...

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Veröffentlicht in:	Journal of investigative dermatology 2013-06, Vol.133 (6), p.1620-1628
Hauptverfasser:	Roggenkamp, Dennis, Köpnick, Sarah, Stäb, Franz, Wenck, Horst, Schmelz, Martin, Neufang, Gitta
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Calcitonin Gene-Related Peptide - metabolism Cell Division - physiology Cells, Cultured Coculture Techniques Dermatitis, Atopic - metabolism Dermatitis, Atopic - physiopathology Dermis - cytology Dermis - innervation Dermis - metabolism Epidermis - cytology Epidermis - innervation Epidermis - metabolism Fibroblasts - cytology Fibroblasts - metabolism Ganglia, Spinal - cytology Ganglia, Spinal - metabolism Humans Keratinocytes - cytology Keratinocytes - metabolism Middle Aged Neuropeptides - metabolism Organ Culture Techniques Peripheral Nervous System - metabolism Peripheral Nervous System - physiopathology Receptor Activity-Modifying Protein 1 - genetics Receptors, Calcitonin Gene-Related Peptide - metabolism Repressor Proteins - genetics RNA, Messenger - metabolism Substance P - metabolism Young Adult
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