Optimal patch application time in the evaluation of skin irritation
We investigated the optimum application for evaluating skin irritation response by using samples of irritants commonly used as additives in cosmetics and other common household products. We studied 47 volunteers (16 men and 31 women). We selected three types of surfactant, one moisturizer, one anti‐...
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| Veröffentlicht in: | Journal of dermatology 2013-05, Vol.40 (5), p.363-369 |
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| container_title | Journal of dermatology |
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| creator | Kanto, Hiromi Washizaki, Kumiko Ito, Masatoshi Matsunaga, Kayoko Akamatsu, Hirohiko Kawai, Keiichi Katoh, Norito Natsuaki, Masaru Yoshimura, Isao Kojima, Hajime Okamoto, Yuko Okuda, Minehiro Kuwahara, Hirofumi Sugiyama, Mariko Kinoshita, Shigemi Mori, Fukuyoshi |
| description | We investigated the optimum application for evaluating skin irritation response by using samples of irritants commonly used as additives in cosmetics and other common household products. We studied 47 volunteers (16 men and 31 women). We selected three types of surfactant, one moisturizer, one anti‐infective agent and one oil solution. Using Finn chambers on Scanpor tape, we performed the patch test. A total of 0.015 mL of each sample was applied to the Finn chamber. For liquids, circular filter paper was soaked in 0.015 mL of the sample. Samples were placed on the upper back of participants, and closed for 4, 24 or 48 h. A patch application time of 24 h is sufficient to detect primary skin irritation from irritants in cosmetics and other common household products. In addition, we found that skin irritation reactions were strongest at 24 h after patch removal and that the reaction tended to be weaker at 48 h after patch removal. Patch testing to evaluate irritants should be performed by means of a 24‐h patch test with a follow‐up reading at 24 h after patch removal. An application time of 24 h places less of a burden on patients than a 48‐h patch test. |
| doi_str_mv | 10.1111/1346-8138.12004 |
| format | Article |
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We studied 47 volunteers (16 men and 31 women). We selected three types of surfactant, one moisturizer, one anti‐infective agent and one oil solution. Using Finn chambers on Scanpor tape, we performed the patch test. A total of 0.015 mL of each sample was applied to the Finn chamber. For liquids, circular filter paper was soaked in 0.015 mL of the sample. Samples were placed on the upper back of participants, and closed for 4, 24 or 48 h. A patch application time of 24 h is sufficient to detect primary skin irritation from irritants in cosmetics and other common household products. In addition, we found that skin irritation reactions were strongest at 24 h after patch removal and that the reaction tended to be weaker at 48 h after patch removal. Patch testing to evaluate irritants should be performed by means of a 24‐h patch test with a follow‐up reading at 24 h after patch removal. An application time of 24 h places less of a burden on patients than a 48‐h patch test.</description><identifier>ISSN: 0385-2407</identifier><identifier>EISSN: 1346-8138</identifier><identifier>DOI: 10.1111/1346-8138.12004</identifier><identifier>PMID: 23414058</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>24-h patch test ; Adult ; Female ; Healthy Volunteers ; Humans ; Japanese standard for evaluating of skin irritation ; Male ; Middle Aged ; new standard for evaluating of skin irritation ; optimum application time ; Patch Tests - methods ; Reference Standards ; Skin Irritancy Tests - methods ; skin irritation response ; sugai scoring ; Time Factors ; Young Adult</subject><ispartof>Journal of dermatology, 2013-05, Vol.40 (5), p.363-369</ispartof><rights>2013 Japanese Dermatological Association</rights><rights>2013 Japanese Dermatological Association.</rights><rights>Copyright © 2013 Japanese Dermatological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4994-840f00149b4b86207a5ada20c34eb4a423c2d43a6cfe7085f7f445b70e2b49453</citedby><cites>FETCH-LOGICAL-c4994-840f00149b4b86207a5ada20c34eb4a423c2d43a6cfe7085f7f445b70e2b49453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1346-8138.12004$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1346-8138.12004$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23414058$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kanto, Hiromi</creatorcontrib><creatorcontrib>Washizaki, Kumiko</creatorcontrib><creatorcontrib>Ito, Masatoshi</creatorcontrib><creatorcontrib>Matsunaga, Kayoko</creatorcontrib><creatorcontrib>Akamatsu, Hirohiko</creatorcontrib><creatorcontrib>Kawai, Keiichi</creatorcontrib><creatorcontrib>Katoh, Norito</creatorcontrib><creatorcontrib>Natsuaki, Masaru</creatorcontrib><creatorcontrib>Yoshimura, Isao</creatorcontrib><creatorcontrib>Kojima, Hajime</creatorcontrib><creatorcontrib>Okamoto, Yuko</creatorcontrib><creatorcontrib>Okuda, Minehiro</creatorcontrib><creatorcontrib>Kuwahara, Hirofumi</creatorcontrib><creatorcontrib>Sugiyama, Mariko</creatorcontrib><creatorcontrib>Kinoshita, Shigemi</creatorcontrib><creatorcontrib>Mori, Fukuyoshi</creatorcontrib><title>Optimal patch application time in the evaluation of skin irritation</title><title>Journal of dermatology</title><addtitle>J Dermatol</addtitle><description>We investigated the optimum application for evaluating skin irritation response by using samples of irritants commonly used as additives in cosmetics and other common household products. We studied 47 volunteers (16 men and 31 women). We selected three types of surfactant, one moisturizer, one anti‐infective agent and one oil solution. Using Finn chambers on Scanpor tape, we performed the patch test. A total of 0.015 mL of each sample was applied to the Finn chamber. For liquids, circular filter paper was soaked in 0.015 mL of the sample. Samples were placed on the upper back of participants, and closed for 4, 24 or 48 h. A patch application time of 24 h is sufficient to detect primary skin irritation from irritants in cosmetics and other common household products. In addition, we found that skin irritation reactions were strongest at 24 h after patch removal and that the reaction tended to be weaker at 48 h after patch removal. Patch testing to evaluate irritants should be performed by means of a 24‐h patch test with a follow‐up reading at 24 h after patch removal. An application time of 24 h places less of a burden on patients than a 48‐h patch test.</description><subject>24-h patch test</subject><subject>Adult</subject><subject>Female</subject><subject>Healthy Volunteers</subject><subject>Humans</subject><subject>Japanese standard for evaluating of skin irritation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>new standard for evaluating of skin irritation</subject><subject>optimum application time</subject><subject>Patch Tests - methods</subject><subject>Reference Standards</subject><subject>Skin Irritancy Tests - methods</subject><subject>skin irritation response</subject><subject>sugai scoring</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPwzAUhS0EglKY2VAkFpbQa_s6jxEKFBDQgZfEYjmpIwxpE-wE6L_HbaADC16udPSdI-sjZI_CEfVvQDlGYUJ5ckQZAK6R3ipZJz3giQgZQrxFtp17BWCpoLBJthhHiiCSHhmO68ZMVRnUqslfAlXXpclVY6pZ4HMdGH9fdKA_VNl2cVUE7s3HxlrTLKMdslGo0undn9snD-dn98OL8Ho8uhweX4c5pimGCUIBQDHNMEsiBrESaqIY5Bx1hgoZz9kEuYryQseQiCIuEEUWg2YZpih4nxx2u7Wt3lvtGjk1LtdlqWa6ap2kXNCIgoi4Rw_-oK9Va2f-dwsKOCQsBU8NOiq3lXNWF7K2XoadSwpy4VcubMqFTbn06xv7P7ttNtWTFf8r1AOiAz5Nqef_7cmr07Pf4bDrGdfor1VP2TcZxTwW8ul2JB_vTm7E8-lQCv4N0ViRbA</recordid><startdate>201305</startdate><enddate>201305</enddate><creator>Kanto, Hiromi</creator><creator>Washizaki, Kumiko</creator><creator>Ito, Masatoshi</creator><creator>Matsunaga, Kayoko</creator><creator>Akamatsu, Hirohiko</creator><creator>Kawai, Keiichi</creator><creator>Katoh, Norito</creator><creator>Natsuaki, Masaru</creator><creator>Yoshimura, Isao</creator><creator>Kojima, Hajime</creator><creator>Okamoto, Yuko</creator><creator>Okuda, Minehiro</creator><creator>Kuwahara, Hirofumi</creator><creator>Sugiyama, Mariko</creator><creator>Kinoshita, Shigemi</creator><creator>Mori, Fukuyoshi</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201305</creationdate><title>Optimal patch application time in the evaluation of skin irritation</title><author>Kanto, Hiromi ; Washizaki, Kumiko ; Ito, Masatoshi ; Matsunaga, Kayoko ; Akamatsu, Hirohiko ; Kawai, Keiichi ; Katoh, Norito ; Natsuaki, Masaru ; Yoshimura, Isao ; Kojima, Hajime ; Okamoto, Yuko ; Okuda, Minehiro ; Kuwahara, Hirofumi ; Sugiyama, Mariko ; Kinoshita, Shigemi ; Mori, Fukuyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4994-840f00149b4b86207a5ada20c34eb4a423c2d43a6cfe7085f7f445b70e2b49453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>24-h patch test</topic><topic>Adult</topic><topic>Female</topic><topic>Healthy Volunteers</topic><topic>Humans</topic><topic>Japanese standard for evaluating of skin irritation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>new standard for evaluating of skin irritation</topic><topic>optimum application time</topic><topic>Patch Tests - methods</topic><topic>Reference Standards</topic><topic>Skin Irritancy Tests - methods</topic><topic>skin irritation response</topic><topic>sugai scoring</topic><topic>Time Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kanto, Hiromi</creatorcontrib><creatorcontrib>Washizaki, Kumiko</creatorcontrib><creatorcontrib>Ito, Masatoshi</creatorcontrib><creatorcontrib>Matsunaga, Kayoko</creatorcontrib><creatorcontrib>Akamatsu, Hirohiko</creatorcontrib><creatorcontrib>Kawai, Keiichi</creatorcontrib><creatorcontrib>Katoh, Norito</creatorcontrib><creatorcontrib>Natsuaki, Masaru</creatorcontrib><creatorcontrib>Yoshimura, Isao</creatorcontrib><creatorcontrib>Kojima, Hajime</creatorcontrib><creatorcontrib>Okamoto, Yuko</creatorcontrib><creatorcontrib>Okuda, Minehiro</creatorcontrib><creatorcontrib>Kuwahara, Hirofumi</creatorcontrib><creatorcontrib>Sugiyama, Mariko</creatorcontrib><creatorcontrib>Kinoshita, Shigemi</creatorcontrib><creatorcontrib>Mori, Fukuyoshi</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kanto, Hiromi</au><au>Washizaki, Kumiko</au><au>Ito, Masatoshi</au><au>Matsunaga, Kayoko</au><au>Akamatsu, Hirohiko</au><au>Kawai, Keiichi</au><au>Katoh, Norito</au><au>Natsuaki, Masaru</au><au>Yoshimura, Isao</au><au>Kojima, Hajime</au><au>Okamoto, Yuko</au><au>Okuda, Minehiro</au><au>Kuwahara, Hirofumi</au><au>Sugiyama, Mariko</au><au>Kinoshita, Shigemi</au><au>Mori, Fukuyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optimal patch application time in the evaluation of skin irritation</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2013-05</date><risdate>2013</risdate><volume>40</volume><issue>5</issue><spage>363</spage><epage>369</epage><pages>363-369</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>We investigated the optimum application for evaluating skin irritation response by using samples of irritants commonly used as additives in cosmetics and other common household products. We studied 47 volunteers (16 men and 31 women). We selected three types of surfactant, one moisturizer, one anti‐infective agent and one oil solution. Using Finn chambers on Scanpor tape, we performed the patch test. A total of 0.015 mL of each sample was applied to the Finn chamber. For liquids, circular filter paper was soaked in 0.015 mL of the sample. Samples were placed on the upper back of participants, and closed for 4, 24 or 48 h. A patch application time of 24 h is sufficient to detect primary skin irritation from irritants in cosmetics and other common household products. In addition, we found that skin irritation reactions were strongest at 24 h after patch removal and that the reaction tended to be weaker at 48 h after patch removal. Patch testing to evaluate irritants should be performed by means of a 24‐h patch test with a follow‐up reading at 24 h after patch removal. An application time of 24 h places less of a burden on patients than a 48‐h patch test.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>23414058</pmid><doi>10.1111/1346-8138.12004</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of dermatology, 2013-05, Vol.40 (5), p.363-369 |
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| subjects | 24-h patch test Adult Female Healthy Volunteers Humans Japanese standard for evaluating of skin irritation Male Middle Aged new standard for evaluating of skin irritation optimum application time Patch Tests - methods Reference Standards Skin Irritancy Tests - methods skin irritation response sugai scoring Time Factors Young Adult |
| title | Optimal patch application time in the evaluation of skin irritation |
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