Toxic effects of pesticide mixtures at a molecular level: Their relevance to human health

Highlights ► Toxic effects of pesticide mixtures can be independent, dose addition or interaction. ► Metabolic interactions involve inhibition or induction of detoxifying enzymes. ► Organophosphates can potentiate pyrethroid, carbaryl and triazine toxicity. ► Synergism occurs when two active pestici...

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Veröffentlicht in:	Toxicology (Amsterdam) 2013-05, Vol.307, p.136-145
Hauptverfasser:	Hernández, Antonio F, Parrón, Tesifón, Tsatsakis, Aristidis M, Requena, Mar, Alarcón, Raquel, López-Guarnido, Olga
Format:	Artikel
Sprache:	eng
Schlagworte:	Addition additive effect Antagonism Carbamates - toxicity carbaryl Carbaryl - toxicity chemical structure Drug Interactions Drug Synergism Emergency Endocrine Disruptors - toxicity endocrine-disrupting chemicals estrogenic properties Herbicides - toxicity human health Humans Hydrocarbons, Chlorinated - toxicity Imidazoles - toxicity Organophosphate Poisoning - etiology organophosphorus compounds Pesticide interactions pesticide mixtures Pesticides - antagonists & inhibitors Pesticides - pharmacology Pesticides - toxicity pharmacokinetics Potentiation prochloraz pyrethrins Synergism toxicity toxicology triazine herbicides Triazines - toxicity
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Beschreibung
Zusammenfassung:	Highlights ► Toxic effects of pesticide mixtures can be independent, dose addition or interaction. ► Metabolic interactions involve inhibition or induction of detoxifying enzymes. ► Organophosphates can potentiate pyrethroid, carbaryl and triazine toxicity. ► Synergism occurs when two active pesticides elicit greater than additive toxicity. ► Endocrine disruptors have the potential for additivity rather than synergism.
ISSN:	0300-483X 1879-3185
DOI:	10.1016/j.tox.2012.06.009