Apicularen A acetate induces cell death via AIF translocation and disrupts the microtubule network by down-regulating tubulin in HM7 human colon cancer cells

•We synthesized the acetyl derivative of the antitumor agent apicularen A.•Apicularen A acetate induces cytotoxicity and sub-G1 accumulation in HM7 cells.•Apicularen A acetate triggers caspase-independent cell death via AIF translocation.•Apicularen A acetate disrupts the microtubule networks by tub...

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Veröffentlicht in:	Biochemical and biophysical research communications 2013-05, Vol.434 (3), p.634-640
Hauptverfasser:	Seo, Kang-Sik, Kim, Hoon, Hong, Tae-Hwa, Kim, Jong-Seok, Song, Kyoung-Sub, Yun, Eun-Jin, Park, Ji-Hoon, Jung, Young-Hoon, Park, Jong-Il, Kweon, Gi Ryang, Yoon, Wan-Hee, Lim, Kyu, Hwang, Byung-Doo
Format:	Artikel
Sprache:	eng
Schlagworte:	Apicularen A acetate Apoptosis - drug effects Apoptosis Inducing Factor - metabolism Apoptosis-inducing factor Blotting, Western Bridged Bicyclo Compounds, Heterocyclic - pharmacology Caspase-independent apoptosis Cell Line, Tumor Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Down-Regulation - drug effects Flow Cytometry Fluorescent Antibody Technique Humans Membrane Potential, Mitochondrial - drug effects Microtubule disruption Microtubules - drug effects Microtubules - metabolism Protein Transport Reverse Transcriptase Polymerase Chain Reaction Tubulin - metabolism
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