Prognostic significance of serum level of vascular endothelial growth factor receptor-2 in hepatocellular carcinoma patients after transcatheter arterial chemoembolization
To explore the prognostic significance of serum vascular endothelial growth factor receptor-2 (VEGFR-2) in patients with hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE). A total of 69 HCC patients undergoing TACE from October 2008 to April 2012 were recruited and...
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| Veröffentlicht in: | Zhong hua yi xue za zhi 2013-01, Vol.93 (5), p.341-344 |
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| container_title | Zhong hua yi xue za zhi |
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| creator | Meng, Qing-wen Li, Yong Hu, Bao-shan Shao, Pei-jian Zhan, Mei-xiao Yu, Xian-yi Lu, Li-gong |
| description | To explore the prognostic significance of serum vascular endothelial growth factor receptor-2 (VEGFR-2) in patients with hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE).
A total of 69 HCC patients undergoing TACE from October 2008 to April 2012 were recruited and examined. Their serum level of VEGFR-2 level was measured by enzyme-linked immunosorbent assay (ELISA). The relationship between VEGFR-2 and their clinicopathologic features were observed. Prognostic significance of VEGFR-2 was assessed for their survival.
Significant differences existed when the serum level of VEGFR-2 was categorized by tumor number and liver cirrhosis (P = 0.021, P = 0.049). The post-treatment serum level of VEGFR-2 was significant higher than that at pre-treatment (P = 0.045). When the mean pre-treatment serum level of VEGFR-2 (8709 ng/L) was used as a cut-off point, the patients with a low serum level of VEGFR-2 had better overall and progression-free survival than those with a high serum leve |
| doi_str_mv | 10.3760/cma.j.issn.0376-2491.2013.05.005 |
| format | Article |
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A total of 69 HCC patients undergoing TACE from October 2008 to April 2012 were recruited and examined. Their serum level of VEGFR-2 level was measured by enzyme-linked immunosorbent assay (ELISA). The relationship between VEGFR-2 and their clinicopathologic features were observed. Prognostic significance of VEGFR-2 was assessed for their survival.
Significant differences existed when the serum level of VEGFR-2 was categorized by tumor number and liver cirrhosis (P = 0.021, P = 0.049). The post-treatment serum level of VEGFR-2 was significant higher than that at pre-treatment (P = 0.045). When the mean pre-treatment serum level of VEGFR-2 (8709 ng/L) was used as a cut-off point, the patients with a low serum level of VEGFR-2 had better overall and progression-free survival than those with a high serum leve</description><identifier>ISSN: 0376-2491</identifier><identifier>DOI: 10.3760/cma.j.issn.0376-2491.2013.05.005</identifier><identifier>PMID: 23660204</identifier><language>chi</language><publisher>China</publisher><subject>Adult ; Aged ; Carcinoma, Hepatocellular - blood ; Chemoembolization, Therapeutic ; Female ; Humans ; Liver Neoplasms - blood ; Male ; Middle Aged ; Prognosis ; Vascular Endothelial Growth Factor Receptor-2 - blood</subject><ispartof>Zhong hua yi xue za zhi, 2013-01, Vol.93 (5), p.341-344</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23660204$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meng, Qing-wen</creatorcontrib><creatorcontrib>Li, Yong</creatorcontrib><creatorcontrib>Hu, Bao-shan</creatorcontrib><creatorcontrib>Shao, Pei-jian</creatorcontrib><creatorcontrib>Zhan, Mei-xiao</creatorcontrib><creatorcontrib>Yu, Xian-yi</creatorcontrib><creatorcontrib>Lu, Li-gong</creatorcontrib><title>Prognostic significance of serum level of vascular endothelial growth factor receptor-2 in hepatocellular carcinoma patients after transcatheter arterial chemoembolization</title><title>Zhong hua yi xue za zhi</title><addtitle>Zhonghua Yi Xue Za Zhi</addtitle><description>To explore the prognostic significance of serum vascular endothelial growth factor receptor-2 (VEGFR-2) in patients with hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE).
A total of 69 HCC patients undergoing TACE from October 2008 to April 2012 were recruited and examined. Their serum level of VEGFR-2 level was measured by enzyme-linked immunosorbent assay (ELISA). The relationship between VEGFR-2 and their clinicopathologic features were observed. Prognostic significance of VEGFR-2 was assessed for their survival.
Significant differences existed when the serum level of VEGFR-2 was categorized by tumor number and liver cirrhosis (P = 0.021, P = 0.049). The post-treatment serum level of VEGFR-2 was significant higher than that at pre-treatment (P = 0.045). When the mean pre-treatment serum level of VEGFR-2 (8709 ng/L) was used as a cut-off point, the patients with a low serum level of VEGFR-2 had better overall and progression-free survival than those with a high serum leve</description><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma, Hepatocellular - blood</subject><subject>Chemoembolization, Therapeutic</subject><subject>Female</subject><subject>Humans</subject><subject>Liver Neoplasms - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Vascular Endothelial Growth Factor Receptor-2 - blood</subject><issn>0376-2491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UMtOwzAQ9AFEEfALyMdeEvzI84gQLwkJDnCuNs66NXLsYDtF8Ev8JCkULrs7o5mRZglZcpbLumIXaoD8NTcxupzNRCaKlueCcZmzMmesPCDH__yCnMVoOlbUshVM8COyELKqmGDFMfl6Cn7tfExG0WjWzmijwCmkXtOIYRqoxS3aHdxCVJOFQNH1Pm3QGrB0Hfx72lANKvlAAyoc5yMT1Di6wRGSV2jtj01BUMb5AehMG3QpUtAJA00BXFQwR-4QhHnuotUGB49D5635nA3enZJDDTbi2X6fkJeb6-eru-zh8fb-6vIhG7moUoay1mVTNJKLvlCct5VsiqoFWfa67kF2otC8aWQt2YwFa0sJSmJX1aC4LrQ8Icvf3DH4twljWg0m7mqAQz_FFZcl42UpGjFLz_fSqRuwX43BDBA-Vn8Plt83_YXe</recordid><startdate>20130129</startdate><enddate>20130129</enddate><creator>Meng, Qing-wen</creator><creator>Li, Yong</creator><creator>Hu, Bao-shan</creator><creator>Shao, Pei-jian</creator><creator>Zhan, Mei-xiao</creator><creator>Yu, Xian-yi</creator><creator>Lu, Li-gong</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20130129</creationdate><title>Prognostic significance of serum level of vascular endothelial growth factor receptor-2 in hepatocellular carcinoma patients after transcatheter arterial chemoembolization</title><author>Meng, Qing-wen ; Li, Yong ; Hu, Bao-shan ; Shao, Pei-jian ; Zhan, Mei-xiao ; Yu, Xian-yi ; Lu, Li-gong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-e37f5848312d4c119638469a35df7da3b24f1883730f7d20953ac3eb67ac1f4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma, Hepatocellular - blood</topic><topic>Chemoembolization, Therapeutic</topic><topic>Female</topic><topic>Humans</topic><topic>Liver Neoplasms - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Vascular Endothelial Growth Factor Receptor-2 - blood</topic><toplevel>online_resources</toplevel><creatorcontrib>Meng, Qing-wen</creatorcontrib><creatorcontrib>Li, Yong</creatorcontrib><creatorcontrib>Hu, Bao-shan</creatorcontrib><creatorcontrib>Shao, Pei-jian</creatorcontrib><creatorcontrib>Zhan, Mei-xiao</creatorcontrib><creatorcontrib>Yu, Xian-yi</creatorcontrib><creatorcontrib>Lu, Li-gong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Zhong hua yi xue za zhi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meng, Qing-wen</au><au>Li, Yong</au><au>Hu, Bao-shan</au><au>Shao, Pei-jian</au><au>Zhan, Mei-xiao</au><au>Yu, Xian-yi</au><au>Lu, Li-gong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of serum level of vascular endothelial growth factor receptor-2 in hepatocellular carcinoma patients after transcatheter arterial chemoembolization</atitle><jtitle>Zhong hua yi xue za zhi</jtitle><addtitle>Zhonghua Yi Xue Za Zhi</addtitle><date>2013-01-29</date><risdate>2013</risdate><volume>93</volume><issue>5</issue><spage>341</spage><epage>344</epage><pages>341-344</pages><issn>0376-2491</issn><abstract>To explore the prognostic significance of serum vascular endothelial growth factor receptor-2 (VEGFR-2) in patients with hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE).
A total of 69 HCC patients undergoing TACE from October 2008 to April 2012 were recruited and examined. Their serum level of VEGFR-2 level was measured by enzyme-linked immunosorbent assay (ELISA). The relationship between VEGFR-2 and their clinicopathologic features were observed. Prognostic significance of VEGFR-2 was assessed for their survival.
Significant differences existed when the serum level of VEGFR-2 was categorized by tumor number and liver cirrhosis (P = 0.021, P = 0.049). The post-treatment serum level of VEGFR-2 was significant higher than that at pre-treatment (P = 0.045). When the mean pre-treatment serum level of VEGFR-2 (8709 ng/L) was used as a cut-off point, the patients with a low serum level of VEGFR-2 had better overall and progression-free survival than those with a high serum leve</abstract><cop>China</cop><pmid>23660204</pmid><doi>10.3760/cma.j.issn.0376-2491.2013.05.005</doi><tpages>4</tpages></addata></record> |
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| ispartof | Zhong hua yi xue za zhi, 2013-01, Vol.93 (5), p.341-344 |
| issn | 0376-2491 |
| language | chi |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Carcinoma, Hepatocellular - blood Chemoembolization, Therapeutic Female Humans Liver Neoplasms - blood Male Middle Aged Prognosis Vascular Endothelial Growth Factor Receptor-2 - blood |
| title | Prognostic significance of serum level of vascular endothelial growth factor receptor-2 in hepatocellular carcinoma patients after transcatheter arterial chemoembolization |
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