Molecular Mechanisms of RNA Interference

Small RNA molecules regulate eukaryotic gene expression during development and in response to stresses including viral infection. Specialized ribonucleases and RNA-binding proteins govern the production and action of small regulatory RNAs. After initial processing in the nucleus by Drosha, precursor...

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Veröffentlicht in:	Annual review of biophysics 2013-01, Vol.42 (1), p.217-239
Hauptverfasser:	Wilson, Ross C, Doudna, Jennifer A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Argonaute Argonaute Proteins - chemistry Argonaute Proteins - metabolism Cell Nucleus - genetics Cell Nucleus - metabolism crystallography Cytoplasm - genetics Cytoplasm - metabolism Dicer dsRNA Gene Expression Regulation Humans MicroRNAs - genetics MicroRNAs - metabolism miRNA Ribonuclease III - genetics Ribonuclease III - metabolism ribonucleoproteins RISC RNA Interference RNA, Small Interfering - genetics RNA, Small Interfering - metabolism RNAi siRNA
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