Beclin-1: Autophagic regulator and therapeutic target in cancer

Beclin-1 (the mammalian ortholog of yeast ATG6) has been well-characterized to play a pivotal role in autophagy that is a major catabolic pathway in which the cell degrades macromolecules and damaged organelles. Beclin-1 structure has been identified to contain three identifiable domains, including...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2013-05, Vol.45 (5), p.921-924
Hauptverfasser:	Fu, Lei-lei, Cheng, Yan, Liu, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Regulatory Proteins - metabolism Apoptosis Regulatory Proteins - physiology Autophagy Autophagy - physiology Beclin-1 Biochemistry Cancer Humans Interactome mammals Membrane Proteins - metabolism Membrane Proteins - physiology Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology nucleoproteins organelles phosphatidylinositol 3-kinase pro-apoptotic proteins yeasts
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