Structure of Nm23-H1 under oxidative conditions

Nm23‐H1/NDPK‐A, a tumour metastasis suppressor, is a multifunctional housekeeping enzyme with nucleoside diphosphate kinase activity. Hexameric Nm23‐H1 is required for suppression of tumour metastasis and it is dissociated into dimers under oxidative conditions. Here, the crystal structure of oxidiz...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Acta crystallographica. Section D, Biological crystallography. Biological crystallography., 2013-04, Vol.69 (4), p.669-680
Hauptverfasser:	Kim, Mi-Sun, Jeong, Jaeho, Jeong, Jihye, Shin, Dong-Hae, Lee, Kong-Joo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Cellular conformational change Cross-Linking Reagents - chemistry Crystal structure Crystallography, X-Ray Cysteine - chemistry Cysteine - genetics disulfides Disulfides - chemistry Enzymes Humans hydrogen/deuterium exchange Kinases mass spectrometry Molecular Dynamics Simulation Molecular Sequence Data Mutation Nanostructure NM23 Nucleoside Diphosphate Kinases - chemistry NM23 Nucleoside Diphosphate Kinases - genetics Nucleosides oxidative modification Oxidative Stress - genetics Peptides Protein Conformation Protein Stability Proteins Reduction sulfonic acid Tumours
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!