Improvement of the antihypertensive capacity of candesartan and trityl candesartan by their SOD mimetic copper(II) complexes

Two new complexes [Cu(Cand)(H2O)4] [1] and [Cu2(TCand)4(H2O)2]·4H2O [2] (Cand = candesartan; TCand = trityl candesartan) have been synthesized and thoroughly characterized. The FTIR, Raman, EPR and diffuse reflectance spectra of the solid compounds show a dimeric complex for [2] with carboxylate bri...

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Veröffentlicht in:	Journal of inorganic biochemistry 2013-06, Vol.123, p.23-33
Hauptverfasser:	Islas, María S., Rojo, Teófilo, Lezama, Luis, Merino, Mercedes Griera, Cortes, María A., Puyol, Manuel Rodriguez, Ferrer, Evelina G., Williams, Patricia A.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - pharmacology Antihypertensive Agents - chemistry Antihypertensive Agents - pharmacology Antihypertensive drugs Antioxidants Antioxidants - metabolism Benzimidazoles - chemistry Benzimidazoles - pharmacology Candesartan Copper - chemistry Copper complexes Human mesangial contractile cells Humans Mesangial Cells - cytology Mesangial Cells - drug effects Mesangial Cells - metabolism Molecular Structure Spectroscopy, Fourier Transform Infrared Superoxide Dismutase - metabolism Tetrazoles - chemistry Tetrazoles - pharmacology
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