Isothermal Microcalorimetry To Investigate the Phase Separation for Amorphous Solid Dispersions of AMG 517 with HPMC-AS

Understanding the crystallization kinetics of an amorphous drug is critical for the development of an amorphous solid dispersion (ASD) formulation. This paper examines the phase separation and crystallization of the drug AMG 517 in ASDs of varying drug load at various conditions of temperature and r...

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Veröffentlicht in:	Molecular pharmaceutics 2013-05, Vol.10 (5), p.1949-1957
Hauptverfasser:	Calahan, Julie L, Zanon, Roger L, Alvarez-Nunez, Fernando, Munson, Eric J
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzothiazoles - chemistry Calorimetry - methods Calorimetry, Differential Scanning Chemistry, Pharmaceutical Crystallization Drug Stability Fluorine Magnetic Resonance Spectroscopy Methylcellulose - analogs & derivatives Microscopy, Electron, Scanning Phase Transition Pyrimidines - chemistry Transition Temperature
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