Valproic acid inhibits the proliferation of cancer cells by re-expressing cyclin D2

In this study, primary murine prostate cancer (PCa) cells were derived using the well-established TRAMP model. These PCa cells were treated with the histone deacetylase inhibitor, valproic acid (VPA), and we demonstrated that VPA treatment has an antimigrative, antiinvasive and antiproliferative eff...

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Veröffentlicht in:	Carcinogenesis (New York) 2013-05, Vol.34 (5), p.1115-1124
Hauptverfasser:	Witt, Daria, Burfeind, Peter, von Hardenberg, Sandra, Opitz, Lennart, Salinas-Riester, Gabriela, Bremmer, Felix, Schweyer, Stefan, Thelen, Paul, Neesen, Jürgen, Kaulfuss, Silke
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation - drug effects Animals Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Movement - drug effects Cell Movement - genetics Cell Proliferation - drug effects Cyclin D2 - biosynthesis Cyclin D2 - genetics Cyclin D2 - metabolism HEK293 Cells Histone Deacetylase Inhibitors - pharmacology Histones - metabolism Humans Male Mice Mice, Inbred C57BL Neoplasm Invasiveness NIH 3T3 Cells Promoter Regions, Genetic - drug effects Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Valproic Acid - pharmacology
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