Role of neutrophil elastase in lung injury induced by burn–blast combined injury in rats

Abstract Objective Neutrophil elastase (NE) takes part in the pathogenesis of acute lung injury. However, its role in lung injury of burn–blast combined injury is unclear. Our objective was to assess the role of NE, and effect of sivelestat, a specific NE inhibitor, in lung injury induced by burn–bl...

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Veröffentlicht in:	Burns 2013-06, Vol.39 (4), p.745-753
Hauptverfasser:	Chai, Jia-ke, Cai, Jian-hua, Deng, Hu-ping, Zou, Xiao-fang, Liu, Wei, Hu, Qing-gang, Shen, Chuan-an, Yin, Hui-nan, Zhang, Xi-bo, Chi, Yun-fei, Ma, Li, Feng, Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blast Injuries - complications Blast Injuries - drug therapy Blast Injuries - enzymology Bronchoalveolar Lavage Fluid - chemistry Burns - complications Burns - drug therapy Burns - enzymology Burn–blast combined injury Carbon Dioxide - metabolism Critical Care Disease Models, Animal Glycine - analogs & derivatives Glycine - therapeutic use Interleukin-8 - metabolism Leukocyte Elastase - physiology Lung injury Lung Injury - drug therapy Lung Injury - enzymology Lung Injury - etiology Male Neutrophil elastase Oxygen - metabolism Partial Pressure Proteinase Inhibitory Proteins, Secretory - therapeutic use Rat Rats Rats, Sprague-Dawley Serine Proteinase Inhibitors - therapeutic use Sulfonamides - therapeutic use Tumor Necrosis Factor-alpha - metabolism
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