Relevance of the cyclophosphamide-induced cystitis model for pharmacological studies targeting inflammation and pain of the bladder

This work aimed at establishing the relevance of using the in vivo model of cyclophosphamide (CYP)-induced bladder inflammation in rats for in vivo pharmacological studies. Specifically, we measured visceral nociception, identified key inflammatory mediators and evaluated the effects of relevant pha...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 2013-05, Vol.707 (1-3), p.32-40
Hauptverfasser:	Augé, Céline, Chene, Gérald, Dubourdeau, Marc, Desoubzdanne, Denis, Corman, Bruno, Palea, Stefano, Lluel, Philippe, Vergnolle, Nathalie, Coelho, Anne-Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	abdomen Analgesics, Opioid - pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology aspirin Aspirin - pharmacology biomarkers Biomarkers - metabolism bladder Cyclophosphamide Cyclophosphamide - toxicity Cystitis Cystitis - complications Cystitis - drug therapy Cystitis - physiopathology Disease Models, Animal edema Female hemorrhage ibuprofen Ibuprofen - pharmacology Inflammation Inflammation - drug therapy Inflammation - etiology Inflammation - pathology Inflammation Mediators - metabolism interleukin-1beta interleukin-6 metabolites morphine Morphine - pharmacology nociception pain pantothenic acid Rat Rats Rats, Sprague-Dawley Reproducibility of Results Time Factors Urinary biomarker urine Visceral pain Visceral Pain - drug therapy Visceral Pain - etiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!