Obesity is a risk factor for thyroid cancer in a large, ultrasonographically screened population
ObjectiveObesity is a well-known risk factor for many cancers, including those of the esophagus, colon, kidney, breast, and skin. However, there are few reports on the relationship between obesity and thyroid cancer. We conducted this study to determine whether obesity is a risk factor for thyroid c...
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| Veröffentlicht in: | European journal of endocrinology 2013-06, Vol.168 (6), p.879-886 |
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| container_title | European journal of endocrinology |
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| creator | Han, Ji Min Kim, Tae Yong Jeon, Min Ji Yim, Ji Hye Kim, Won Gu Song, Dong Eun Hong, Suck Joon Bae, Sung Jin Kim, Hong-Kyu Shin, Myung-Hee Shong, Young Kee Kim, Won Bae |
| description | ObjectiveObesity is a well-known risk factor for many cancers, including those of the esophagus, colon, kidney, breast, and skin. However, there are few reports on the relationship between obesity and thyroid cancer. We conducted this study to determine whether obesity is a risk factor for thyroid cancer by systematically screening a selected population by ultrasonography.Design and methodsWe obtained data from 15 068 subjects that underwent a routine health checkup from 2007 to 2008 at the Health Screening and Promotion Center of Asan Medical Center. Thyroid ultrasonography was included in the checkup, and suspicious nodules were examined by ultrasonography-guided aspiration. Those with a history of thyroid disease or family history of thyroid cancer were excluded from this study.ResultsIn total, 15 068 subjects, 8491 men and 6577 women, were screened by thyroid ultrasonography. Fine-needle aspiration cytology was performed in 1427 of these patients based on the predefined criteria and thyroid cancer was diagnosed in 267 patients. The prevalence of thyroid cancer in women was associated with a high BMI (per 5 kg/m2 increase) (odds ratios (OR)=1.63, 95% CI 1.24–2.10, P |
| doi_str_mv | 10.1530/EJE-13-0065 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1349092570</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1349092570</sourcerecordid><originalsourceid>FETCH-LOGICAL-b440t-9e05b5864244fd44dc407d2f7bf246f7f76bc4822e02412d7014bfce3ba42a383</originalsourceid><addsrcrecordid>eNp90DtPBCEQwHFiNHo-KntDY2KiqwPMPq405nzFxEYTuxVYUHRvWWG3uG8vlzu1syBQ_GZI_oQcMjhnuYCL2f0sYyIDKPINMmFYTrOiEi-bZAIVYIYFih2yG-MHAEtv2CY7XORMcMEm5PVRmeiGBXWRShpc_KRW6sEHatMZ3hfBu4Zq2WkTqOuSaWV4M2d0bIcgo-_8W5D9u9OybRc06mBMZxra-35s5eB8t0-2rGyjOVjfe-T5evZ0dZs9PN7cXV0-ZAoRhmxqIFd5VSBHtA1ioxHKhttSWY6FLW1ZKI0V5wY4Mt6UwFBZbYSSyKWoxB45We3tg_8aTRzquYvatK3sjB9jzQROYcrzEhI9XVEdfIzB2LoPbi7DomZQL5PWKWkaqJdJkz5aLx7V3DS_9qdhAsdrIGPKYEOK5eKfK5FXIl8uYiunnI_amW5wNnX79_NvLDSOcA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1349092570</pqid></control><display><type>article</type><title>Obesity is a risk factor for thyroid cancer in a large, ultrasonographically screened population</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Han, Ji Min ; Kim, Tae Yong ; Jeon, Min Ji ; Yim, Ji Hye ; Kim, Won Gu ; Song, Dong Eun ; Hong, Suck Joon ; Bae, Sung Jin ; Kim, Hong-Kyu ; Shin, Myung-Hee ; Shong, Young Kee ; Kim, Won Bae</creator><creatorcontrib>Han, Ji Min ; Kim, Tae Yong ; Jeon, Min Ji ; Yim, Ji Hye ; Kim, Won Gu ; Song, Dong Eun ; Hong, Suck Joon ; Bae, Sung Jin ; Kim, Hong-Kyu ; Shin, Myung-Hee ; Shong, Young Kee ; Kim, Won Bae</creatorcontrib><description>ObjectiveObesity is a well-known risk factor for many cancers, including those of the esophagus, colon, kidney, breast, and skin. However, there are few reports on the relationship between obesity and thyroid cancer. We conducted this study to determine whether obesity is a risk factor for thyroid cancer by systematically screening a selected population by ultrasonography.Design and methodsWe obtained data from 15 068 subjects that underwent a routine health checkup from 2007 to 2008 at the Health Screening and Promotion Center of Asan Medical Center. Thyroid ultrasonography was included in the checkup, and suspicious nodules were examined by ultrasonography-guided aspiration. Those with a history of thyroid disease or family history of thyroid cancer were excluded from this study.ResultsIn total, 15 068 subjects, 8491 men and 6577 women, were screened by thyroid ultrasonography. Fine-needle aspiration cytology was performed in 1427 of these patients based on the predefined criteria and thyroid cancer was diagnosed in 267 patients. The prevalence of thyroid cancer in women was associated with a high BMI (per 5 kg/m2 increase) (odds ratios (OR)=1.63, 95% CI 1.24–2.10, P<0.001), after adjustment for age, smoking status, and TSH levels. There was no positive correlation between the prevalence of thyroid cancer in men and a high BMI (OR=1.16, 95% CI 0.85–1.57, P=0.336). There was no association between age, fasting serum insulin, or basal TSH levels and thyroid cancer in either gender.ConclusionsObesity was associated with a higher prevalence of thyroid cancer in women when evaluated in a routine health checkup setting. This association between risk factor and disease was unrelated to serum insulin and TSH levels. Additional studies are needed to understand the mechanism(s) behind the association of obesity with thyroid cancer risk.</description><identifier>ISSN: 0804-4643</identifier><identifier>EISSN: 1479-683X</identifier><identifier>DOI: 10.1530/EJE-13-0065</identifier><identifier>PMID: 23513231</identifier><language>eng</language><publisher>Bristol: BioScientifica</publisher><subject>Adult ; Biological and medical sciences ; Clinical Study ; Endocrinopathies ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Insulin - metabolism ; Male ; Malignant tumors ; Medical sciences ; Metabolic diseases ; Middle Aged ; Obesity ; Obesity - complications ; Obesity - epidemiology ; Obesity - metabolism ; Risk Factors ; Thyroid Neoplasms - diagnostic imaging ; Thyroid Neoplasms - epidemiology ; Thyroid Neoplasms - etiology ; Thyroid Neoplasms - metabolism ; Thyroid. Thyroid axis (diseases) ; Thyrotropin - metabolism ; Ultrasonography ; Vertebrates: endocrinology</subject><ispartof>European journal of endocrinology, 2013-06, Vol.168 (6), p.879-886</ispartof><rights>2013 European Society of Endocrinology</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b440t-9e05b5864244fd44dc407d2f7bf246f7f76bc4822e02412d7014bfce3ba42a383</citedby><cites>FETCH-LOGICAL-b440t-9e05b5864244fd44dc407d2f7bf246f7f76bc4822e02412d7014bfce3ba42a383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27428355$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23513231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Ji Min</creatorcontrib><creatorcontrib>Kim, Tae Yong</creatorcontrib><creatorcontrib>Jeon, Min Ji</creatorcontrib><creatorcontrib>Yim, Ji Hye</creatorcontrib><creatorcontrib>Kim, Won Gu</creatorcontrib><creatorcontrib>Song, Dong Eun</creatorcontrib><creatorcontrib>Hong, Suck Joon</creatorcontrib><creatorcontrib>Bae, Sung Jin</creatorcontrib><creatorcontrib>Kim, Hong-Kyu</creatorcontrib><creatorcontrib>Shin, Myung-Hee</creatorcontrib><creatorcontrib>Shong, Young Kee</creatorcontrib><creatorcontrib>Kim, Won Bae</creatorcontrib><title>Obesity is a risk factor for thyroid cancer in a large, ultrasonographically screened population</title><title>European journal of endocrinology</title><addtitle>Eur J Endocrinol</addtitle><description>ObjectiveObesity is a well-known risk factor for many cancers, including those of the esophagus, colon, kidney, breast, and skin. However, there are few reports on the relationship between obesity and thyroid cancer. We conducted this study to determine whether obesity is a risk factor for thyroid cancer by systematically screening a selected population by ultrasonography.Design and methodsWe obtained data from 15 068 subjects that underwent a routine health checkup from 2007 to 2008 at the Health Screening and Promotion Center of Asan Medical Center. Thyroid ultrasonography was included in the checkup, and suspicious nodules were examined by ultrasonography-guided aspiration. Those with a history of thyroid disease or family history of thyroid cancer were excluded from this study.ResultsIn total, 15 068 subjects, 8491 men and 6577 women, were screened by thyroid ultrasonography. Fine-needle aspiration cytology was performed in 1427 of these patients based on the predefined criteria and thyroid cancer was diagnosed in 267 patients. The prevalence of thyroid cancer in women was associated with a high BMI (per 5 kg/m2 increase) (odds ratios (OR)=1.63, 95% CI 1.24–2.10, P<0.001), after adjustment for age, smoking status, and TSH levels. There was no positive correlation between the prevalence of thyroid cancer in men and a high BMI (OR=1.16, 95% CI 0.85–1.57, P=0.336). There was no association between age, fasting serum insulin, or basal TSH levels and thyroid cancer in either gender.ConclusionsObesity was associated with a higher prevalence of thyroid cancer in women when evaluated in a routine health checkup setting. This association between risk factor and disease was unrelated to serum insulin and TSH levels. Additional studies are needed to understand the mechanism(s) behind the association of obesity with thyroid cancer risk.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Clinical Study</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Insulin - metabolism</subject><subject>Male</subject><subject>Malignant tumors</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - epidemiology</subject><subject>Obesity - metabolism</subject><subject>Risk Factors</subject><subject>Thyroid Neoplasms - diagnostic imaging</subject><subject>Thyroid Neoplasms - epidemiology</subject><subject>Thyroid Neoplasms - etiology</subject><subject>Thyroid Neoplasms - metabolism</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Thyrotropin - metabolism</subject><subject>Ultrasonography</subject><subject>Vertebrates: endocrinology</subject><issn>0804-4643</issn><issn>1479-683X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90DtPBCEQwHFiNHo-KntDY2KiqwPMPq405nzFxEYTuxVYUHRvWWG3uG8vlzu1syBQ_GZI_oQcMjhnuYCL2f0sYyIDKPINMmFYTrOiEi-bZAIVYIYFih2yG-MHAEtv2CY7XORMcMEm5PVRmeiGBXWRShpc_KRW6sEHatMZ3hfBu4Zq2WkTqOuSaWV4M2d0bIcgo-_8W5D9u9OybRc06mBMZxra-35s5eB8t0-2rGyjOVjfe-T5evZ0dZs9PN7cXV0-ZAoRhmxqIFd5VSBHtA1ioxHKhttSWY6FLW1ZKI0V5wY4Mt6UwFBZbYSSyKWoxB45We3tg_8aTRzquYvatK3sjB9jzQROYcrzEhI9XVEdfIzB2LoPbi7DomZQL5PWKWkaqJdJkz5aLx7V3DS_9qdhAsdrIGPKYEOK5eKfK5FXIl8uYiunnI_amW5wNnX79_NvLDSOcA</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Han, Ji Min</creator><creator>Kim, Tae Yong</creator><creator>Jeon, Min Ji</creator><creator>Yim, Ji Hye</creator><creator>Kim, Won Gu</creator><creator>Song, Dong Eun</creator><creator>Hong, Suck Joon</creator><creator>Bae, Sung Jin</creator><creator>Kim, Hong-Kyu</creator><creator>Shin, Myung-Hee</creator><creator>Shong, Young Kee</creator><creator>Kim, Won Bae</creator><general>BioScientifica</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130601</creationdate><title>Obesity is a risk factor for thyroid cancer in a large, ultrasonographically screened population</title><author>Han, Ji Min ; Kim, Tae Yong ; Jeon, Min Ji ; Yim, Ji Hye ; Kim, Won Gu ; Song, Dong Eun ; Hong, Suck Joon ; Bae, Sung Jin ; Kim, Hong-Kyu ; Shin, Myung-Hee ; Shong, Young Kee ; Kim, Won Bae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b440t-9e05b5864244fd44dc407d2f7bf246f7f76bc4822e02412d7014bfce3ba42a383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Clinical Study</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Insulin - metabolism</topic><topic>Male</topic><topic>Malignant tumors</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Obesity - epidemiology</topic><topic>Obesity - metabolism</topic><topic>Risk Factors</topic><topic>Thyroid Neoplasms - diagnostic imaging</topic><topic>Thyroid Neoplasms - epidemiology</topic><topic>Thyroid Neoplasms - etiology</topic><topic>Thyroid Neoplasms - metabolism</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Thyrotropin - metabolism</topic><topic>Ultrasonography</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Ji Min</creatorcontrib><creatorcontrib>Kim, Tae Yong</creatorcontrib><creatorcontrib>Jeon, Min Ji</creatorcontrib><creatorcontrib>Yim, Ji Hye</creatorcontrib><creatorcontrib>Kim, Won Gu</creatorcontrib><creatorcontrib>Song, Dong Eun</creatorcontrib><creatorcontrib>Hong, Suck Joon</creatorcontrib><creatorcontrib>Bae, Sung Jin</creatorcontrib><creatorcontrib>Kim, Hong-Kyu</creatorcontrib><creatorcontrib>Shin, Myung-Hee</creatorcontrib><creatorcontrib>Shong, Young Kee</creatorcontrib><creatorcontrib>Kim, Won Bae</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Ji Min</au><au>Kim, Tae Yong</au><au>Jeon, Min Ji</au><au>Yim, Ji Hye</au><au>Kim, Won Gu</au><au>Song, Dong Eun</au><au>Hong, Suck Joon</au><au>Bae, Sung Jin</au><au>Kim, Hong-Kyu</au><au>Shin, Myung-Hee</au><au>Shong, Young Kee</au><au>Kim, Won Bae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obesity is a risk factor for thyroid cancer in a large, ultrasonographically screened population</atitle><jtitle>European journal of endocrinology</jtitle><addtitle>Eur J Endocrinol</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>168</volume><issue>6</issue><spage>879</spage><epage>886</epage><pages>879-886</pages><issn>0804-4643</issn><eissn>1479-683X</eissn><abstract>ObjectiveObesity is a well-known risk factor for many cancers, including those of the esophagus, colon, kidney, breast, and skin. However, there are few reports on the relationship between obesity and thyroid cancer. We conducted this study to determine whether obesity is a risk factor for thyroid cancer by systematically screening a selected population by ultrasonography.Design and methodsWe obtained data from 15 068 subjects that underwent a routine health checkup from 2007 to 2008 at the Health Screening and Promotion Center of Asan Medical Center. Thyroid ultrasonography was included in the checkup, and suspicious nodules were examined by ultrasonography-guided aspiration. Those with a history of thyroid disease or family history of thyroid cancer were excluded from this study.ResultsIn total, 15 068 subjects, 8491 men and 6577 women, were screened by thyroid ultrasonography. Fine-needle aspiration cytology was performed in 1427 of these patients based on the predefined criteria and thyroid cancer was diagnosed in 267 patients. The prevalence of thyroid cancer in women was associated with a high BMI (per 5 kg/m2 increase) (odds ratios (OR)=1.63, 95% CI 1.24–2.10, P<0.001), after adjustment for age, smoking status, and TSH levels. There was no positive correlation between the prevalence of thyroid cancer in men and a high BMI (OR=1.16, 95% CI 0.85–1.57, P=0.336). There was no association between age, fasting serum insulin, or basal TSH levels and thyroid cancer in either gender.ConclusionsObesity was associated with a higher prevalence of thyroid cancer in women when evaluated in a routine health checkup setting. This association between risk factor and disease was unrelated to serum insulin and TSH levels. Additional studies are needed to understand the mechanism(s) behind the association of obesity with thyroid cancer risk.</abstract><cop>Bristol</cop><pub>BioScientifica</pub><pmid>23513231</pmid><doi>10.1530/EJE-13-0065</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Biological and medical sciences Clinical Study Endocrinopathies Female Fundamental and applied biological sciences. Psychology Humans Insulin - metabolism Male Malignant tumors Medical sciences Metabolic diseases Middle Aged Obesity Obesity - complications Obesity - epidemiology Obesity - metabolism Risk Factors Thyroid Neoplasms - diagnostic imaging Thyroid Neoplasms - epidemiology Thyroid Neoplasms - etiology Thyroid Neoplasms - metabolism Thyroid. Thyroid axis (diseases) Thyrotropin - metabolism Ultrasonography Vertebrates: endocrinology |
| title | Obesity is a risk factor for thyroid cancer in a large, ultrasonographically screened population |
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