Intracellular cleavable poly(2-dimethylaminoethyl methacrylate) functionalized mesoporous silica nanoparticles for efficient siRNA delivery in vitro and in vivo

A low cytotoxicity and high efficiency delivery system with the advantages of low cost and facile fabrication is needed for the application of small interfering RNA (siRNA) delivery both in vitro and in vivo. For these prerequisites, cationic polymer-mesoporous silica nanoparticles (ssCP-MSNs) were...

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Veröffentlicht in:	Nanoscale 2013-05, Vol.5 (10), p.4291-4301
Hauptverfasser:	Lin, Daoshu, Cheng, Qiang, Jiang, Qian, Huang, Yuanyu, Yang, Zheng, Han, Shangcong, Zhao, Yuning, Guo, Shutao, Liang, Zicai, Dong, Anjie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Drug Delivery Systems Female HeLa Cells Heterografts Humans Male Methacrylates - chemistry Methacrylates - pharmacokinetics Methacrylates - pharmacology Mice Mice, Inbred BALB C Mice, Nude Nanoparticles - chemistry Nanoparticles - ultrastructure Neoplasm Transplantation Neoplasms, Experimental - drug therapy Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Particle Size Polymers - chemistry Polymers - pharmacokinetics Polymers - pharmacology RNA Interference - drug effects RNA, Small Interfering - chemistry RNA, Small Interfering - pharmacokinetics RNA, Small Interfering - pharmacology Silicon Dioxide - chemistry Silicon Dioxide - pharmacokinetics Silicon Dioxide - pharmacology
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