A Mild and Efficient Flow Procedure for the Transfer Hydrogenation of Ketones and Aldehydes using Hydrous Zirconia

A Mild and Efficient Flow Procedure for the Transfer Hydrogenation of Ketones and Aldehydes using Hydrous Zirconia

A flow chemistry Meerwein–Ponndorf–Verley (MPV) reduction procedure using partially hydrated zirconium oxide via a machine-assisted approach is reported. The heterogeneous reductive system could be applied to a wide range of functionalized substrates, allowing clean and fast delivery of the alcohol...

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Veröffentlicht in:Organic letters 2013-05, Vol.15 (9), p.2278-2281
Hauptverfasser: Battilocchio, Claudio, Hawkins, Joel M, Ley, Steven V
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols - chemistry
Aldehydes - chemistry
Catalysis
Hydrogenation
Ketones - chemistry
Stereoisomerism
Zirconium - chemistry
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Zusammenfassung:A flow chemistry Meerwein–Ponndorf–Verley (MPV) reduction procedure using partially hydrated zirconium oxide via a machine-assisted approach is reported. The heterogeneous reductive system could be applied to a wide range of functionalized substrates, allowing clean and fast delivery of the alcohol products within a few minutes (6–75 min). In three examples the system was scaled to deliver 50 mmol of product.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol400856g