Mitogen‐activated protein kinase 2 regulates physiological and pathological bone turnover

The objective of this study was to investigate the role of the serine‐threonine kinase mitogen‐activated protein kinase 2 (MK2) in bone homeostasis. Primary bone cell cultures from MK2+/+ and MK2–/– mice were assessed for osteoclast and osteoblast differentiation, bone resorption, and gene expressio...

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Veröffentlicht in:	Journal of bone and mineral research 2013-04, Vol.28 (4), p.936-947
Hauptverfasser:	Braun, Tobias, Lepper, Johannes, Ruiz Heiland, Gisela, Hofstetter, Willy, Siegrist, Mark, Lezuo, Patrick, Gaestel, Matthias, Rumpler, Monika, Thaler, Roman, Klaushofer, Klaus, Distler, Jörg HW, Schett, Georg, Zwerina, Jochen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Remodeling BONE RESORPTION Bone Resorption - pathology Cell Count Estrogens - deficiency Estrogens - metabolism Female Male Mice, Inbred C57BL Mitogen-Activated Protein Kinase 1 - deficiency Mitogen-Activated Protein Kinase 1 - metabolism MITOGEN‐ACTIVATED PROTEIN KINASES MK2 Organ Size Osteoblasts - metabolism Osteoblasts - pathology Osteoclasts - metabolism Osteoclasts - pathology Osteogenesis OSTEOPOROSIS Osteoprotegerin - metabolism Ovariectomy
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